Results 101 to 110 of about 95,678 (274)

Influence of Codon Bias on Heterologous Production of Human Papillomavirus Type 16 Major Structural Protein L1 in Yeast

The Scientific World Journal, 2012
Heterologous gene expression is dependent on multistep processes involving regulation at the level of transcription, mRNA turnover, protein translation, and posttranslational modifications.
Milda Norkiene, Alma Gedvilaite
doaj   +1 more source

The Selective Advantage of Synonymous Codon Usage Bias in Salmonella. [PDF]

PLoS Genetics, 2016
The genetic code in mRNA is redundant, with 61 sense codons translated into 20 different amino acids. Individual amino acids are encoded by up to six different codons but within codon families some are used more frequently than others. This phenomenon is
Gerrit Brandis, Diarmaid Hughes
doaj   +1 more source

The Mystery of Two Straight Lines in Bacterial Genome Statistics. Release 2007

, 2007
In special coordinates (codon position--specific nucleotide frequencies) bacterial genomes form two straight lines in 9-dimensional space: one line for eubacterial genomes, another for archaeal genomes. All the 348 distinct bacterial genomes available in
A. Carbone, A. Gorban, A. Muto, A. N. Gorban, A. Y. Zinovyev, A.N. Gorban, A.Y. Zinovyev, C. Minichini, D. Bharanidharan, D.J. Lynn, E. Carlon, E. Yeramian, E. Yeramian, G.A.C. Singer, J. Besemer, J. Lobry, J.R. Lobry, J.R. Lobry, L. Frappat, L. Pachter, N. Sueoka, N. Sueoka, R. Cangelosi, R.D. Knight, S.L. Chen, X.F. Wan   +25 more
core   +4 more sources

Machine Learning‐Enhanced Random Matrix Theory Design for Human Immunodeficiency Virus Vaccine Development

Advanced Intelligent Discovery, EarlyView.
This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah, Muhammad Zulqarnain Zeb, Muhammad Husnain Zeb, Babar Shabbir   +3 more
wiley   +1 more source

Intraspecific and interspecific variations in the synonymous codon usage in mitochondrial genomes of 8 pleurotus strains

BMC Genomics
In this study, we investigated the codon bias of twelve mitochondrial core protein coding genes (PCGs) in eight Pleurotus strains, two of which are from the same species.
Wei Gao, Xiaodie Chen, Jing He, Ajia Sha, Yingyong Luo, Wenqi Xiao, Zhuang Xiong, Qiang Li   +7 more
doaj   +1 more source

A study on the codon usage bias of arenavirus common genes

Frontiers in Microbiology
IntroductionThe Arenaviridae family consists of the genera Mammarenavirus, Reptarenavirus, Hartmanivirus, Antennavirus and Innmovirus. The codon usage bias between the different genera has not yet been studied comparatively.MethodsWe retrieved the ...
Pablo Daniel Thomas, María Florencia Ferrer, Mauricio J. Lozano, Ricardo Martín Gómez   +3 more
doaj   +1 more source

Why genes evolve faster on secondary chromosomes in bacteria [PDF]

, 2010
In bacterial genomes composed of more than one chromosome, one replicon is typically larger, harbors more essential genes than the others, and is considered primary.
Cooper, Vaughn S., Hatcher, Philip J., Vohr, Samuel H., Wrocklage, Sarah C.   +3 more
core   +1 more source

Marfan Syndrome Associated With Intellectual Disability and Behavioral Anomalies: Further Evidence for the Effect of Compound Heterozygous Variants in FBN1 on Phenotypic Severity

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Marfan syndrome (MFS) is a rare connective tissue disorder characterized by involvement of the cardiovascular, ocular, and musculoskeletal systems. Pathogenic variants in FBN1 cause most of the MFS cases; however, intellectual disability (ID) is rarely observed. A non‐consanguineous Pakistani family with four affected individuals was recruited.
Azmatullah Khan, Naseebullah Kakar, Ainullah Kakar, Malte Spielmann, Sajid Malik   +4 more
wiley   +1 more source

Novel MYL1 Intron Variant With Expanded Phenotype

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Congenital myopathy‐14 (CMYO14) is an ultrarare autosomal recessive disorder caused by biallelic variants in MYL1, with only four patients reported to date. We describe what is likely the fifth reported patient, a neonate with severe hypotonia, respiratory insufficiency, and skeletal anomalies showing distinct histological changes of skeletal ...
Maria Barington, Marie Balslev‐Harder, Thomas Krag, Thomas van Overeem Hansen, Camilla Bernt Wulff, Ulrik Lausten‐Thomsen, Tina Duelund Hjortshøj, Elsebet Østergaard   +7 more
wiley   +1 more source

Analysis of factors shaping synonymous codon usage in pseudorabies virus

浙江大学学报. 农业与生命科学版, 2007
Synonymous codon usage and the main factors shaping codon usage in pseudorabies virus were reported in order to understand the architecture and evolution of pseudorabies virus.
YIN Hua-ping, GUO Wan-zhu, XU Zhi-wen, YANG Li   +3 more
doaj   +1 more source