Results 221 to 230 of about 95,678 (274)

Hydroxyl radical footprinting modification reveals an intradomain communication pathway in EFL1 disrupted by a Shwachman‐Diamond syndrome‐associated mutation

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Shwachman‐Diamond syndrome (SDS) is a rare genetic disorder characterized by pancreatic insufficiency and neutropenia. While most cases are linked to mutations in the SBDS gene, some involve mutations in the GTPase EFL1. This protein works with SBDS to release the anti‐association factor eIF6 from the 60S ribosomal subunit during ribosome ...
Jonathan A. Zúñiga‐Domínguez, Rohit Jain, Martín González‐Andrade, Erik R. Farquhar, Mark R. Chance, Abril Gijsbers, Nuria Sánchez‐Puig   +6 more
wiley   +1 more source

Reliable Inference of Phylogenomic Relationship via Assembly‐Based Strategy Accommodating Raw Reads and Proteins

Molecular Ecology Resources, Volume 26, Issue 3, April 2026.
ABSTRACT Phylogenomics is a transformative approach in systematics, conservation biology, and biomedical research, enabling the inference of evolutionary relationships by leveraging hundreds to thousands of genes from genomic or transcriptomic data. However, acquiring high‐quality genomes and transcriptomes necessitates samples with intact DNA and RNA,
Yunlong Li, Xu Liu, Chong Chen, Jian‐Wen Qiu, Kevin M. Kocot, Jin Sun   +5 more
wiley   +1 more source

Tetraopes Milkweed Beetle Genomes Elucidate the Adaptive Basis of a Temperate Coevolutionary Radiation

Molecular Ecology Resources, Volume 26, Issue 3, April 2026.
ABSTRACT The coevolutionary radiation of 27 species of Tetraopes longhorned beetles and their Asclepias milkweed hosts represents a classic example of adaptive evolution driven by plant chemical defences and herbivore counteradaptations. Investigations to date, however, have focused on a single species, Tetraopes tetrophthalmus, which feeds on the ...
Sangil Kim, Brian D. Farrell
wiley   +1 more source

Accounting for Intra‐ and Intergenomic Sequence Variation in Reference Barcodes Improves eDNA Metabarcoding Biodiversity Assessment

Molecular Ecology Resources, Volume 26, Issue 3, April 2026.
ABSTRACT Environmental DNA (eDNA) metabarcoding can rapidly characterise biodiversity, yet its accuracy and effectiveness are limited by incomplete DNA barcode reference databases. We evaluated how comprehensive reference databases that include sequence variation within genomes (intragenomic) and across individuals and species (intergenomic) improve ...
Luke J. McCartin, Samuel A. Vohsen, Annemarie L. Wood, Jeremy Horowitz, José J. Orozco‐Juarbe, Nicole Pittoors, Declan Morrissey, Claudia F. Vaga, Colleen M. Hansel, Allen G. Collins, Andrea M. Quattrini, Santiago Herrera   +11 more
wiley   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Commitment to Myogenic Differentiation Significantly Aggravates the RNA Phenotype in Myotonic Dystrophy Type 1

Neuropathology and Applied Neurobiology, Volume 52, Issue 2, April 2026.
DM1 myoblasts show mild defects, but RNA toxicity intensifies upon differentiation, where broad gene‐expression changes and escalating MBNL1‐driven splicing defects disrupt muscle‐specific pathways, underscoring a key vulnerability at the transition from myogenic precursor cells to myofibres in patients. ABSTRACT Aims Myotonic dystrophy type 1 (DM1) is
Lise Ripken, Walther J. A. A. van den Broek, Remco T. P. van Cruchten, Jos G. A. Smits, Tabea V. Riepe, Peter A. C. 't Hoen, Derick G. Wansink   +6 more
wiley   +1 more source

Evolutionary mobility and genetic dynamics of MORFFO genes: shuttling among ancient plant lineages

New Phytologist, Volume 250, Issue 2, Page 1248-1264, April 2026.
Summary Plastid genomes (plastomes) of land plants are characterized by their architectural and genic content stability. However, fern plastomes exhibit unexpected dynamism, characterized by the presence of mobile protein‐coding genes (CDS) – Mobile Open Reading Frames in Fern Organelles (MORFFOs). We investigate the evolutionary dynamics of MORFFOs in
Paulo H. Labiak, Li‐Yaung Kuo, Blake D. Fauskee, Kenneth G. Karol   +3 more
wiley   +1 more source

Engineering of the Flavone Rutinoside Biosynthetic Pathway Enables Production of Diosmin, a Venoactive Compound in Solanum lycopersicum and Nicotiana tabacum

Plant Biotechnology Journal, Volume 24, Issue 4, Page 1936-1949, April 2026.
ABSTRACT Diosmin is often used as a dietary supplement, and it is sometimes used to make phlebotropic drugs for venous diseases. Traditionally, diosmin is obtained by the dehydrogenation of the flavanone glycoside hesperidin through chemical semisynthesis.
Qianle Zhang, Qingwen Wu, Wenjing Shi, Yinai Deng, Ruoting Zhan, Dongming Ma   +5 more
wiley   +1 more source

Mapping the inter- and intra-genic codon-usage landscape in <i>Homo sapiens</i>. [PDF]

NAR Genom Bioinform
Arshad M, Uchmanowicz M, Rana V, Trost B, Scherer SW, Rafiq MA.   +5 more
europepmc   +1 more source

Adult T‐cell leukemia/lymphoma in French Guiana (1990–2019): Epidemiology, clinical features, and HTLV‐1 genetic diversity in the two main ethnic populations

International Journal of Cancer, Volume 158, Issue 6, Page 1528-1540, 15 March 2026.
What's new? Adult T‐cell leukemia/lymphoma (ATL) is a rare and aggressive malignancy caused by human T‐cell leukemia virus type 1 (HTLV‐1). The authors comprehensively analyzed the epidemiological and clinical features of ATL over a 30‐year period in French Guiana, a region with high HTLV‐1 endemicity and a multiethnic population.
Jill‐Léa Ramassamy, Patricia Tortevoye, Balthazar Ntab, Gabriel Carles, Jean‐Pierre Droz, Pierre Couppié, Giovanni Begliomini, Jean‐Francois Carod, N'detodji‐Bill Wankpo, Karim Abdelmoumen, Philippe V. Afonso, Olivier Cassar, Antoine Talarmin, Olivier Hermine, Loïc Epelboin, Ambroise Marçais, Antoine Gessain   +16 more
wiley   +1 more source