Results 81 to 90 of about 95,149 (294)
BMC Genomics, 2022 Background Codon usage bias (CUB), the non-uniform usage of synonymous codons, occurs across all domains of life. Adaptive CUB is hypothesized to result from various selective pressures, including selection for efficient ribosome elongation, accurate ...
Alexander L. Cope, Michael A. Gilchrist
doaj +1 more source
Pattern of synonymous codon usage in three strains of human coxsackievirus [PDF]
, 2014 The pattern of synonymous codon usage in organisms is not displayed in a random fashion. Some codons are used more frequently than the alternative synonymous codons. This phenomenon is found across species and across genes within a genome.
Tee, Sim-Hui
core
Codon Usage in Prokaryotes [PDF]
Biotechnology & Biotechnological Equipment, 2008 ABSTRACTAdvances in DNA sequencing led to accumulation of genomic data of a great number of prokaryotes belonging to different taxons. In this study we have analyzed 158 prokaryotic genomes for codon usage specificity. The latter is studied not only on the level of the whole genome (all genes) but also for three gene subsets: highly expressed genes ...
B. Bachvarov, K. Kirilov, I. Ivanov
openaire +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
MicroorganismsNeboviruses (NeVs) from the Caliciviridae family have been linked to enteric diseases in bovines and have been detected worldwide. As viruses rely entirely on the cellular machinery of the host for replication, their ability to thrive in a specific host ...
Rahul Kaushik +8 more
doaj +1 more source
Data in support of large scale comparative codon usage analysis in Leishmania and Trypanosomatids
Data in Brief, 2015 This data article contains data related to the article “Comparison of codon usage bias across Leishmania and Trypanosomatids to understand mRNA secondary structure, relative protein abundance and pathway functions” by Subramanian and Sarkar, Genomics ...
Abhishek Subramanian, Ram Rup Sarkar
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Estimating translational selection in Eukaryotic Genomes [PDF]
, 2008 Natural selection on codon usage is a pervasive force that acts on a large variety of prokaryotic and eukaryotic genomes. Despite this, obtaining reliable estimates of selection on codon usage has proved complicated, perhaps due to the fact that the ...
M. dos Reis +43 more
core +2 more sources
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
Virology Journal, 2023 Background Since the onset of the SARS-CoV-2 pandemic, bioinformatic analyses have been performed to understand the nucleotide and synonymous codon usage features and mutational patterns of the virus.
Sarah E. Fumagalli +7 more
doaj +1 more source