Results 81 to 90 of about 1,107,083 (308)
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Data in support of large scale comparative codon usage analysis in Leishmania and Trypanosomatids
Data in Brief, 2015 This data article contains data related to the article “Comparison of codon usage bias across Leishmania and Trypanosomatids to understand mRNA secondary structure, relative protein abundance and pathway functions” by Subramanian and Sarkar, Genomics ...
Abhishek Subramanian, Ram Rup Sarkar
doaj +1 more source
BMC Genomics, 2022 Background Codon usage bias (CUB), the non-uniform usage of synonymous codons, occurs across all domains of life. Adaptive CUB is hypothesized to result from various selective pressures, including selection for efficient ribosome elongation, accurate ...
Alexander L. Cope, Michael A. Gilchrist
doaj +1 more source
Codon usage frequency analysis.
, 2016 A. Codon usage frequency of GP64sp and its mutants. B. Codon usage frequency of FibHsp and its mutants. Numbers from 1 to 22 stand for the codon positions in the indicated signal sequences.
Xiaodong Xu (276342) +4 more
core +1 more source
, 2023 (A) Relative synonymous codon usage (RSCU) of N. montanus. (B) Heatmap indicates codon usage in 31 Coreoidea species. (C) Heatmap indicates amino acid usage in 31 Coreoidea species.
Xiaoke Tian (14599962) +3 more
core +1 more source
Codon Usage in Prokaryotes [PDF]
Biotechnology & Biotechnological Equipment, 2008 ABSTRACTAdvances in DNA sequencing led to accumulation of genomic data of a great number of prokaryotes belonging to different taxons. In this study we have analyzed 158 prokaryotic genomes for codon usage specificity. The latter is studied not only on the level of the whole genome (all genes) but also for three gene subsets: highly expressed genes ...
B. Bachvarov, K. Kirilov, I. Ivanov
openaire +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
MicroorganismsNeboviruses (NeVs) from the Caliciviridae family have been linked to enteric diseases in bovines and have been detected worldwide. As viruses rely entirely on the cellular machinery of the host for replication, their ability to thrive in a specific host ...
Rahul Kaushik +8 more
doaj +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source