Results 101 to 110 of about 36,066 (191)

Codon usage modulates the relationship between the burden and yield of protein overexpression

Journal of Biological Engineering
Background Excess utilization of translational resources is a critical source of burden on cells engineered to overexpress exogenous proteins. To improve translational efficiency, researchers often modify codon usage in an exogenous gene to more closely ...
Cameron T. Roots, Alexis M. Hill, Claus O. Wilke, Jeffrey E. Barrick   +3 more
doaj   +1 more source

Models and measures of codon usage bias

, 2013
Second term paper for my Biol L533 class (evolution of genes and genomes) with Mike Lynch, Winter term 2013. Bias in the usage of synonymous codons has been observed in all major taxa. Various mechanistic models have been proposed to explain this bias, some motivated by adaptive selection on features such as translational e ciency, and some motivated ...
openaire   +1 more source

Synonymous codon usage defines functional gene families

BMC Biology
Background The degeneracy of the genetic code is increasingly recognized for roles in regulating translation rate, protein folding, and cell response. However, the functional genomics of codon usage patterns remains poorly defined.
Farzan Ghanegolmohammadi, Shinsuke Ohnuki, Shane Byrne, Rahul Raman, Thomas J. Begley, Peter C. Dedon   +5 more
doaj   +1 more source

Codon usage bias in Archaea

, 2011
Synonymous codon usage bias has been extensively studied in Bacteria and Eukaryotes and yet there has been little investigation in the third domain of life, the Archaea. In this thesis I therefore examine the coding sequences of nearly 70 species of Archaea to explore patterns of codon bias.
openaire   +2 more sources

Codon usage bias analysis of 22 Anemone

Highlights in Science, Engineering and Technology
Codon preference analysis for the rbcL gene of Ranunculaceae plants remains to be completed, and for this purpose we selected 10801 codons from 23 Ranunculaceae Juss. plants for analysis. Among them, 30 codons had relative synonymous codon usage values greater than or equal to 1.
openaire   +1 more source

Codon usage bias and selective constraints in Gentianales mitogenomes. [PDF]

BMC Genomics
Amenu SG, Yiying L, Oyebanji O, Eshetu G, Mwaniki AW, Tao W.   +5 more
europepmc   +1 more source

Codon Usage Bias Analysis of Citrus Leaf Blotch Virus. [PDF]

Viruses
Ren X, Xu L, Yan Y, Wang Y, Huang A.
europepmc   +1 more source

Patterns and drivers of genome-wide codon usage bias in the fungal order Sordariales. [PDF]

DNA Res
Hensen N, Hiltunen Thorén M, Johannesson H.   +2 more
europepmc   +1 more source

Availability of Charged tRNAs Drives Maximal Protein Synthesis at Intermediate Levels of Codon Usage Bias. [PDF]

Bull Math Biol
Hill AM, To K, Wilke CO.
europepmc   +1 more source

Unconventional codon usage bias mediates mRNA translational dynamics in macrophages. [PDF]

PLoS Biol
Luo S, Wang Q, Chen A, Huang L, Liu Y, Zong X, Mao Y.   +6 more
europepmc   +1 more source