Results 141 to 150 of about 18,552 (255)

Toward a minimal amino acid alphabet for protein design

The FEBS Journal, EarlyView.
Proteins are built from 20 canonical amino acids; however, it is interesting to investigate whether they can also be formed from reduced amino acid alphabets. Using protein design, we designed proteins based on all alphabets comprising 2 to 10 ‘early’ amino acids (those likely to have been present before the origin of life).
Karel Půbal, Kseniia Kushnir, Vojtěch Spiwok, Karolína Loužecká, Vladimír Setnička, Petra Lipovová   +5 more
wiley   +1 more source

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source

Codon Usage Bias Variation and Evolutionary Signatures of Epstein-Barr Virus in Distinct Epithelial Cancers. [PDF]

Viruses
Li X, Huang X, Li WT, Baele G, Liu L, Li S, Dai J, He WT.   +7 more
europepmc   +1 more source

Genome‐scale evidence for host‐associated lineage divergence in the parasitoid, Microctonus aethiopoides

Insect Molecular Biology, EarlyView.
Host associations are primary drivers of genomic divergence, with clear phylogenetic separation observed between strains associated with Hypera and Sitona weevil hosts. Genomic diversity aligns with reproductive modes: sexually reproducing ancestral lineages maintain high heterozygosity, while derived asexual strains exhibit reduced heterozygosity and ...
Meeran Hussain, Elahe Parvizi, Mark R. McNeill, Angela McGaughran   +3 more
wiley   +1 more source

Codon Usage Bias and Phylogenetic Analysis of the Mitochondrial Genomes in Two <i>Enicurus</i> Species. [PDF]

Genes (Basel)
Qian L, Zan J, Liu H, Liu T, Zhao J, Li X.   +5 more
europepmc   +1 more source

Genomic dissection of divergent selection reveals a roadmap for reciprocal improvement of Chinese and American soybean

Journal of Integrative Plant Biology, EarlyView.
Genomic dissection of 2,377 soybean accessions identified 261 trait‐associated loci with distinct beneficial alleles in Chinese and American germplasms, enabled development of the Soybean Targeted Improvement Navigation System framework for targeted allele introgression, and provided genomic resources for knowledge‐driven soybean design breeding ...
Chengzhi Jiao, Delin Li, Hao Zhang, Zhongren Zhang, Xueqing Wang, Long Yan, Tianqing Zheng, Chaosen Zhao, Hongmei Qiu, Guangnan Xing, Guoyu Hu, Like Liu, Qiang Wang, Wen Huang, Xing Wang, Yumin Wang, Long Miao, YanFei Li, Xin Jing, Xiaojian Fang, Yu Tian, Ying‐Hui Li, Xiaobo Wang, Li‐Juan Qiu   +23 more
wiley   +1 more source

Mutation Pressure and Gene-Specific Selection Shape Codon Usage Bias in the Chloroplast Genomes of <i>Isoetes</i>, an Ancient Aquatic Vascular Plant Lineage. [PDF]

Ecol Evol
Li B, Xue Y, Zhang D, Smagghe G, Liang S, Wang S, Ge Y, Aimaitijiang Z, Gai Y.   +8 more
europepmc   +1 more source

Indices of Codon Usage Bias

Journal of Proteomics & Bioinformatics, 2017
openaire   +1 more source

Vicariance and dispersal in the Aegean Archipelago: Molecular phylogeography reveals the origin and divergence times of Hydropsyche (Trichoptera: Hydropsychidae) species

Journal of Systematics and Evolution, EarlyView.
Divergence times of Greek Hydropsyche lineages fall mostly within the Pliocene‐Pleistocene, rejecting ancient vicariance. Widespread species show shallow divergences consistent with dispersal, while island endemics exhibit deeper isolation patterns supporting a mixed vicariance‐dispersal model.
Anastasia Lampou, Paraskevi Niki Lampri, Cesc Múrria, Ioannis Karaouzas, Nikolaos Skoulikidis, Núria Bonada   +5 more
wiley   +1 more source

Analysis of Chloroplast Genome Characteristics and Codon Usage Bias of <i>Styphnolobium japonicum</i> f. <i>oligophyllum</i>. [PDF]

Curr Issues Mol Biol
Mu ZQ, Zhang X, Yan JJ, Chen BP, Wang HW.   +4 more
europepmc   +1 more source