Results 71 to 80 of about 36,066 (191)
International Journal of Genomics, 2014 It is vital to unravel the codon usage bias in order to gain insights into the evolutionary forces dictating the viral evolution process. Influenza A virus has attracted attention of many investigators over the years due to high mutation rate and being ...
Himangshu Deka, Supriyo Chakraborty
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Microbial Cell Factories, 2021 Background Codon optimization is a common method to improve protein expression levels in Pichia pastoris and the current strategy is to replace rare codons with preferred codons to match the codon usage bias.
Yide Huang +6 more
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Selection on Codon Usage for Error Minimization at the Protein Level [PDF]
, 2018 Given the structure of the genetic code, synonymous codons differ in their capacity to minimize the effects of errors due to mutation or mistranslation.
Archetti, Marco
core
Highly syntenic and yet divergent: a tale of two Theilerias [PDF]
, 2009 The published genomic sequences of the two major host-transforming Theileria species of cattle represent a rich resource of information that has allowed novel bioinformatic and experimental studies into these important apicomplexan parasites. Since their
Bishop, R. +8 more
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Maximizing Transcription Efficiency Causes Codon Usage Bias
Genetics, 1996 Abstract The rate of protein synthesis depends on both the rate of initiation of translation and the rate of elongation of the peptide chain. The rate of initiation depends on the encountering rate between ribosomes and mRNA; this rate in turn depends on the concentration of ribosomes and mRNA. Thus, patterns of codon usage that increase
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Evolutionary rates and gene dispensability associate with replication timing in the Archaeon Sulfolobus islandicus [PDF]
, 2010 In bacterial chromosomes, the position of a gene relative to the single origin of replication generally reflects its replication timing, how often it is expressed, and consequently, its rate of evolution.
Cooper, Vaughn S. +3 more
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Analysis of synonymous codon usage bias in 09H1N1
Virologica Sinica, 2010 A novel subtype of influenza A virus 09H1N1 has rapidly spread across the world. Evolutionary analyses of this virus have revealed that 09H1N1 is a triple reassortant of segments from swine, avian and human influenza viruses. In this study, we investigated factors shaping the codon usage bias of 09H1N1 and carried out cluster analysis of 60 strains of ...
Zhen-Peng, Li +5 more
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Relative Codon Adaptation Index, a Sensitive Measure of Codon Usage Bias
Evolutionary Bioinformatics, 2010 We propose a simple, sensitive measure of synonymous codon usage bias, the Relative Codon Adaptation Index (rCAI), as a way to discriminate better between highly biased and unbiased regions, compared with the widely used Codon Adaptation Index (CAI). CAI is a geometric mean of the relative usage of codons in a gene, and is calculated using the codon ...
Lee, S Lee, Soo Hyun +3 more
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Good Codons, Bad Transcript: Large Reductions in Gene Expression and Fitness Arising from Synonymous Mutations in a Key Enzyme [PDF]
, 2014 Biased codon usage in protein-coding genes is pervasive, whereby amino acids are largely encoded by a specific subset of possible codons. Within individual genes, codon bias is stronger at evolutionarily conserved residues, favoring codons recognized by ...
Agashe, Deepa +3 more
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Analysis of Synonymous Codon Usage Bias in Flaviviridae Virus [PDF]
BioMed Research International, 2019 Background. Flaviviridae viruses are single-stranded, positive-sense RNA viruses, which threat human constantly mediated by mosquitoes, ticks, and sandflies. Considering the recent increase in the prevalence of the family virus and its risk potential, we investigated the codon usage pattern to understand its evolutionary processes and provide some ...
Huipeng Yao, Mengyu Chen, Zizhong Tang
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