Results 41 to 50 of about 6,471 (200)

Coelenterazine distribution and luciferase characteristics in oceanic decapod crustaceans

, 1995
Coelenterazine biosynthesis has recently been demonstrated in the developing eggs of the decapod Systellaspis debilis. The cellular source of coelenterazine and the potential for biosynthesis in adult decapods, however, have not been fully investigated ...
Herring, P. J., Thomson, Catherine M., Campbell, Anthony Keith   +2 more
core   +1 more source

Chemical structure of Coelenterazine and Cypridina luciferin.

, 2012
Chemical structure of Coelenterazine and Cypridina luciferin.
Ira Schildkraut (29742), Ezra Schildkraut (8680), George Tzertzinis (154499)   +2 more
core   +1 more source

Systematic profiling reveals broad G protein coupling and context‐dependent modulation of cyclic AMP by the orphan receptor GPR139

British Journal of Pharmacology, EarlyView.
Background and Purpose G protein‐coupled receptors (GPCRs) are major drug targets, yet many orphan receptors remain poorly characterized. GPR139 has been implicated in CNS disorders, including schizophrenia and depression, but its signalling mechanisms remain unclear.
Boris Trapkov, Hans Bräuner, Alexander Sebastian Hauser   +2 more
wiley   +1 more source

Sulfuryl group transfer from coelenterazine sulfate to PAP by other sulfotransferases.

, 2022
We surveyed four sulfotransferases (STs) for their ability to transfer the sulfate from coelenterazine sulfate to PAP producing coelenterazine. The mouse estrogen ST was chosen based on sequence similarity (Fig 9) to the Coel-ST and the others based on ...
Ira Schildkraut (29742), Ivan R. Corrêa Jr. (11083985), Laurence Ettwiller (15718), George Tzertzinis (154499), Jack Benner (9571), Elizabeth Brown (281332), Colleen McClung (3402752), Brenda Baker (174368)   +7 more
core   +1 more source

Symplectin evolved from multiple duplications in bioluminescent squid [PDF]

PeerJ, 2017
The squid Sthenoteuthis oualaniensis, formerly Symplectoteuthis oualaniensis, generates light using the luciferin coelenterazine and a unique enzyme, symplectin.
Warren R. Francis, Lynne M. Christianson, Steven H.D. Haddock   +2 more
doaj   +2 more sources

Introducing a new reporter gene, membrane-anchored Cypridina luciferase, for multiplex bioluminescence imaging

Molecular Therapy: Oncolytics, 2021
Bioluminescence reporter gene imaging is a robust, high-throughput imaging modality that is useful for tracking cells and monitoring biological processes, both in cell culture and in small animals.
Maxim A. Moroz, Juan Zurita, Anna Moroz, Ekaterina Nikolov, Yury Likar, Konstantin Dobrenkov, Jason Lee, Larissa Shenker, Ronald Blasberg, Inna Serganova, Vladimir Ponomarev   +10 more
doaj   +1 more source

Positive modulation of glucagon‐like peptide 1 (GLP‐1) receptor by endogenous haemorphins with implications in glucose metabolism and diabetes

British Journal of Pharmacology, EarlyView.
Haemorphins act on GLP‐1 receptor (GLP‐1R) activity and signalling in a positive allosteric manner. This leads to potentiated GLP‐1‐mediated activity and signalling, as well as insulin synthesis, which may have implications for glucose metabolism and, thereby, diabetes and obesity. (The graph was created in BioRender.com).
Farheen Badrealam Khan, Rwdah Mohamed Alameri, Yasir S. Raouf, Damien Maurel, Naiem Ahmad Wani, Anatoliy Shmygol, Irfa Anwar, Heng B. See, Elizabeth K. M. Johnstone, Elodie Dupuis, Eric Trinquet, Kevin D. G. Pfleger, Emilia Oueis, Mohammed Akli Ayoub   +13 more
wiley   +1 more source

HeLa cells produce coelenterazine chemiluminescence in vitro.

, 2016
(A) 5x105 HeLa cells were imaged sequentially, at 5 min intervals for 1 hour. (B) Quantification of HeLa (black) or buffer (white) coelenterazine chemiluminescence at each time point (n = 3).
Laura L. Bronsart (844933), Christian Stokes (844934), Christopher H. Contag (219505)   +2 more
core   +1 more source

A comprehensive study on ferredoxin isoforms in the cyanobacterium Synechocystis sp. PCC 6803

The FEBS Journal, EarlyView.
Ferredoxins are small FeS cluster‐containing proteins that play a central role in distributing electrons within the cell. The cyanobacterium Synechocystis sp. PCC 6803 contains several ferredoxin isoforms and their biophysical properties (UV/Vis and EPR spectra, Em potential), expression patterns, and interactions with the electron donors photosystem I
Marko Boehm, Drazenka Svedruzic, Carolyn E. Lubner, Jens Appel, David W. Mulder, Effie C. Kisgeropoulos, Vanessa Hueren, Katharina Spengler, Vivek S. Bharadwaj, Zhanjun Guo, Anastasia E. Ledinina, Darja Deobald, Lorenz Adrian, Paul W. King, Kirstin Gutekunst   +14 more
wiley   +1 more source

Maintain the light, long-term seasonal monitoring of luminous capabilities in the brittle star Amphiura filiformis

Scientific Reports
The European brittle star Amphiura filiformis emits blue light, via a Renilla-like luciferase, which depends on the dietary acquisition of coelenterazine.
Constance Coubris, Laurent Duchatelet, Jérôme Delroisse, Wendy Shirley Bayaert, Laura Parise, Marie Christine Eloy, Christophe Pels, Jérôme Mallefet   +7 more
doaj   +1 more source