Results 41 to 50 of about 5,761 (165)

Synthesis and Biological Activity of 2,6‐Disubstituted and 2,6,9‐Trisubstituted 7‐Deazapurine Nucleobases

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Four series of 20 (het)aryl substituted 7‐deazapurine nucleobases were synthesized. Several potent antagonists of all four subtypes of adenosine receptors were identified by functional assay. High‐throughput screening of the IMTM compound library for modulatory activity on adenosine receptors (ARs) identified two deazapurine hits based on 2,6‐diaryl‐7 ...
Ugnė Šinkevičiūtė, Kateřina Burgetová Ječmeňová, Soňa Gurská, Lenka Poštová Slavětínská, Vincent Baran, Pavel Polishchuk, Petr Džubák, Michal Hocek, Marián Hajdúch, Michal Tichý   +9 more
wiley   +1 more source

5‐HT2A receptor agonism by tert‐leucinamide and valinamide synthetic cannabinoids: In vitro and in vivo evidence

British Journal of Pharmacology, Volume 183, Issue 16, Page 4715-4734, August 2026.
Abstract Background and Purpose New synthetic cannabinoid receptor agonists (SCRAs) are associated with severe adverse effects, including unexpected psychiatric symptoms. These compounds are mainly active through their potent agonism on the cannabinoid receptors CB1 and CB2.
Giorgia Corli, Deborah Rudin, Dino Luethi, Matthias E. Liechti, Sabrine Bilel, Matteo Marti, Henrik Green, Manuela Carla Monti, Caitlyn Norman   +8 more
wiley   +1 more source

Es werde Licht! Licht als Antrieb und Regulator in synthetischen Zellen

Angewandte Chemie, Volume 138, Issue 24, 8 June 2026.
Zellen sind Systeme außerhalb des Gleichgewichts, die ihre Eigenschaften in Raum und Zeit regulieren. In biomimetischen synthetischen Zellen bietet Licht eine einzigartige Möglichkeit, Vorgänge räumlich und zeitlich anzutreiben und zu kontrollieren.
Matthew E. Allen, Saskia Frank, Mehaiarii Louis, Atreyee Saha, Ali Heidari, Seraphine V. Wegner   +5 more
wiley   +1 more source

In Vivo Testing of Luciferase Substrate Analogs in an Orthotopic Murine Model of Human Glioblastoma

Molecular Imaging, 2006
In vivo bioluminescent imaging using cells expressing Renilla luciferase is becoming increasingly common. Hindrances to the more widespread use of Renilla luciferase are the high autoluminescence of its natural substrate, coelenterazine, in plasma; the ...
Maya Otto-Duessel, Vazgen Khankaldyyan, Ignacio Gonzalez-Gomez, Michael C. Jensen, Walter E. Laug, Michael Rosol   +5 more
doaj   +1 more source

Let There be Light! Light as an Engine and Regulator in Synthetic Cells

Angewandte Chemie International Edition, Volume 65, Issue 24, 8 June 2026.
Cells are out‐of‐equilibrium systems that regulate their spatiotemporal features. In biomimetic synthetic cells, light offers a unique way for energizing and regulating events in space and time. This review explores the implementation of light‐responsive tools in synthetic cells to replicate biological functions and enable new bioinspired behaviors ...
Matthew E. Allen, Saskia Frank, Mehaiarii Louis, Atreyee Saha, Ali Heidari, Seraphine V. Wegner   +5 more
wiley   +1 more source

Nanodiamond Quantum Sensors for Probing Free Radical Biology

Advanced Functional Materials, Volume 36, Issue 45, 5 June 2026.
Free radicals play key roles in cellular signaling and disease but remain difficult to measure in living systems. Nanodiamonds (NDs) with nitrogen‐vacancy (NV) centers enable quantum sensing of local magnetic noise via T₁ relaxometry, providing nondestructive radical detection in living cells.
Qi Lu, Yingke Wu, Tanja Weil
wiley   +1 more source

Crystal structure of semi-synthetic obelin-v after calcium induced bioluminescence implies coelenteramine as the main reaction product

Scientific Reports, 2022
Coelenterazine-v (CTZ-v), a synthetic vinylene-bridged π-extended derivative, is able to significantly alter bioluminescence spectra of different CTZ-dependent luciferases and photoproteins by shifting them towards longer wavelengths.
Pavel V. Natashin, Elena V. Eremeeva, Mikhail B. Shevtsov, Margarita I. Kovaleva, Sergey S. Bukhdruker, Daria A. Dmitrieva, Dmitry V. Gulnov, Elena V. Nemtseva, Valentin I. Gordeliy, Alexey V. Mishin, Valentin I. Borshchevskiy, Eugene S. Vysotski   +11 more
doaj   +1 more source

Mechanoadaptation via Myosin Cytoplasmic Redistribution Protects Circulating Tumor Cells From Shear‐induced Death During Hematogenous Dissemination

Advanced Science, Volume 13, Issue 33, 15 June 2026.
This study investigates how CTCs survive varying shear stress during hematogenous metastasis. We uncover a self‐protection mechanism, by which non‐adherent CTCs adapt to high shearing milieu through accumulated cytoplasmic myosin‐mediated disruption of myosin‐actin binding, attenuating force transmission into chromatin to protect CTCs from shear ...
Cunyu Zhang, Qianchun Wang, Keming Li, Guanshuo Hu, Ying Xin, Kai Tang, Bing Hu, Pengyu Du, Renwei Mao, Baohua Ji, Youhua Tan   +10 more
wiley   +1 more source

Comprehensive transduceromic profiling of NOP receptor ligands at different Gα subunits

British Journal of Pharmacology, Volume 183, Issue 12, Page 3195-3212, June 2026.
Abstract Background and Purpose The nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) is an opioid receptor family member with distinct pharmacology and broad therapeutic potential. NOP receptors regulate functions such as nociception, stress reactivity, reward, mood, autonomic tone, immunity and sleep/wake cycle.
Davide Malfacini, Riccardo Camilotto, Michele Maritan, Erika Morrone, Stephen Afriyie Boateng, Anna Vacilotto, Salvatore Pacifico, Remo Guerrini, Nurulain T. Zaveri, Girolamo Calo'   +9 more
wiley   +1 more source

Luciferase-Specific Coelenterazine Analogues for Optical Contamination-Free Bioassays

Scientific Reports, 2017
Spectral overlaps among the multiple optical readouts commonly cause optical contamination in fluorescence and bioluminescence. To tackle this issue, we created five-different lineages of coelenterazine (CTZ) analogues designed to selectively illuminate ...
Ryo Nishihara, Masahiro Abe, Shigeru Nishiyama, Daniel Citterio, Koji Suzuki, Sung Bae Kim   +5 more
doaj   +1 more source