Results 31 to 40 of about 5,761 (165)

Combined Experimental and Theoretical Investigation into the Photophysical Properties of Halogenated Coelenteramide Analogs

Molecules, 2022
Marine Coelenterazine is one of the most well-known chemi-/bioluminescent systems, and in which reaction the chemi-/bioluminophore (Coelenteramide) is generated and chemiexcited to singlet excited states (leading to light emission).
Ana Carolina P. Afonso, Patricia González-Berdullas, Joaquim C. G. Esteves da Silva, Luís Pinto da Silva   +3 more
doaj   +1 more source

Coelenterazine Derivatives as Potential Drugs for Photodynamic Therapy

Medical Sciences Forum, 2022
Cancer is one of the main leading causes of death worldwide, and its treatment is highly complex and known to cause serious side effects for patients.
Daiane Nascimento Maronde, Ivo E. Sampaio-Dias, Luís Pinto da Silva, Leandro M. O. Lourenço, José E. Rodríguez-Borges   +4 more
doaj   +1 more source

A putative chordate luciferase from a cosmopolitan tunicate indicates convergent bioluminescence evolution across phyla

Scientific Reports, 2020
Pyrosomes are tunicates in the phylum Chordata, which also contains vertebrates. Their gigantic blooms play important ecological and biogeochemical roles in oceans. Pyrosoma, meaning “fire-body”, derives from their brilliant bioluminescence.
Michael Tessler, Jean P. Gaffney, Anderson G. Oliveira, Andrew Guarnaccia, Krista C. Dobi, Nehaben A. Gujarati, Moira Galbraith, Jeremy D. Mirza, John S. Sparks, Vincent A. Pieribone, Robert J. Wood, David F. Gruber   +11 more
doaj   +1 more source

Comprehensive in vitro profiling of traditional and emerging stimulants at monoamine transporters and the 5‐HT2A receptor

British Journal of Pharmacology, EarlyView.
A pharmacological profiling of 58 synthetic stimulants of various classes at dopamine, norepinephrine, and serotonin transporters and the 5‐HT2A receptor, most showing distinct class‐dependent profiles, with some indicating a high abuse potential. Background and Purpose New psychoactive substances (NPSs) often emerge on the illicit drug market with ...
Darta Stalberga, Robert Kronstrand, Bianca Schranz, Nick van Zijl, Sebastian Karlman, Soma Aref, Tobias Rautio, Svante Vikingsson, Mattias Persson, Henrik Green   +9 more
wiley   +1 more source

Symplectin evolved from multiple duplications in bioluminescent squid [PDF]

PeerJ, 2017
The squid Sthenoteuthis oualaniensis, formerly Symplectoteuthis oualaniensis, generates light using the luciferin coelenterazine and a unique enzyme, symplectin.
Warren R. Francis, Lynne M. Christianson, Steven H.D. Haddock   +2 more
doaj   +2 more sources

Introducing a new reporter gene, membrane-anchored Cypridina luciferase, for multiplex bioluminescence imaging

Molecular Therapy: Oncolytics, 2021
Bioluminescence reporter gene imaging is a robust, high-throughput imaging modality that is useful for tracking cells and monitoring biological processes, both in cell culture and in small animals.
Maxim A. Moroz, Juan Zurita, Anna Moroz, Ekaterina Nikolov, Yury Likar, Konstantin Dobrenkov, Jason Lee, Larissa Shenker, Ronald Blasberg, Inna Serganova, Vladimir Ponomarev   +10 more
doaj   +1 more source

Agonist‐specific conformational dynamics at the β2‐adrenoceptor dictate allosteric modulation of Gαs signalling and bronchodilation

British Journal of Pharmacology, Volume 183, Issue 17, Page 5315-5335, September 2026.
Abstract Background and Purpose β2‐adrenoceptor (β2AR) agonists are the cornerstone of asthma therapy and promote bronchodilation through Gαs signalling in airway smooth muscle (ASM), but their efficacy is limited by β‐arrestin‐mediated β2AR desensitization.
Sushrut D. Shah, Joshua Richard, Suvankar Ghosh, Jillian Jerwick, Joice T. Gavali, Raymond B. Penn, Alexander D. MacKerell Jr, Deepak A. Deshpande   +7 more
wiley   +1 more source

The chemokine receptor‐like fourth extracellular loop of the apelin receptor differentially regulates apelin and elabela binding and signalling

British Journal of Pharmacology, Volume 183, Issue 18, Page 5641-5656, September 2026.
Abstract Background and Purpose Apelin and Elabela are endogenous ligands of the apelin receptor (apelin receptor/APJ), a GPCR involved in cardiovascular regulation and body fluid homeostasis. The human receptor contains a conserved disulfide bridge linking the N‐terminal domain to extracellular loop 3 (ECL3) via Cys19 and Cys281, forming a structural ...
Chloé Bonef, Hela Bouhsine, Carine Huynh, Marion Chaigneau, Steven Dubois, Mikel Garcia‐Marcos, Catherine Llorens‐Cortes, Denis Servent, Philippe Robin, Hervé Nozach, Isabel Alves, Xavier Iturrioz   +11 more
wiley   +1 more source

A tomato MIK2‐clade receptor is involved in the perception of a Fusarium‐derived elicitor

New Phytologist, Volume 251, Issue 5, Page 2777-2798, September 2026.
Fusarium elicitor responsivness and MIK2‐clade proteins are conserved across plant families. Summary Plants continuously monitor their environment to adapt to threats affecting health and fitness. Cell‐surface receptors detect conserved microbe‐associated molecular patterns (MAMPs) or endogenous immunogenic signals to activate signaling pathways that ...
Julian Maroschek, Yvonne Rösgen, Clemens Rössner, Simon Snoeck, Claus Schwechheimer, Cyril Zipfel, Ralph Hückelhoven   +6 more
wiley   +1 more source

Bioluminescent imaging of Trypanosoma brucei shows preferential testis dissemination which may hamper drug efficacy in sleeping sickness. [PDF]

PLoS Neglected Tropical Diseases, 2009
Monitoring Trypanosoma spread using real-time imaging in vivo provides a fast method to evaluate parasite distribution especially in immunoprivileged locations.
Filip Claes, Suman K Vodnala, Nick van Reet, Nathalie Boucher, Hilda Lunden-Miguel, Theo Baltz, Bruno Maria Goddeeris, Philippe Büscher, Martin E Rottenberg   +8 more
doaj   +1 more source