Results 31 to 40 of about 7,015 (221)
Coelenterazine analogues emit red-shifted bioluminescence with NanoLuc
Org. Biomol. Chem., 2017 Synthesis and biological investigation of coelenterazine analogs that demonstrate a tunable red-shift in their bioluminescent emission with NanoLuc luciferase.
Anton Shakhmin +5 more
openaire +3 more sources
Coelenterazine alleviates sepsis-associated acute kidney injury by inhibiting ferroptosis via the USP14-NCOA4 pathway. [PDF]
Transl Androl UrolBackground Sepsis-associated acute kidney injury (S-AKI) is a frequent and severe complication of sepsis driven by systemic inflammation, oxidative stress, and vascular dysfunction, culminating in renal tubular injury and impaired excretory function ...
Bao D +12 more
europepmc +2 more sources
Organic and biomolecular chemistry, 2019 An original gram-scale synthesis of O-acetylated forms of coelenterazine, furimazine or hydroxy-bearing analogues of luciferins is described. The comparison over two hours of their bioluminescence, using the nanoKAZ/NanoLuc luciferase, provides ...
Eloi P. Coutant +7 more
semanticscholar +2 more sources
Bioluminescent properties of obelin and aequorin with novel coelenterazine analogues
Analytical and Bioanalytical Chemistry, 2014 The main analytical use of Ca(2+)-regulated photoproteins from luminous coelenterates is for real-time non-invasive visualization of intracellular calcium concentration ([Ca(2+)]i) dynamics in cells and whole organisms. A limitation of this approach for in vivo deep tissue imaging is the fact that blue light emitted by the photoprotein is highly ...
Gealageas, Ronan +7 more
openaire +4 more sources
Biomedicines, 2021 Zebrafish embryos and larvae have emerged as an excellent model in cardiovascular research and are amenable to live imaging with genetically encoded biosensors to study cardiac cell behaviours, including calcium dynamics. To monitor calcium ion levels in
Manuel Vicente +7 more
doaj +1 more source
Structures of coelenterazine and coelenterazine sulfate and their interconversion.
, 2022 Structures of coelenterazine and coelenterazine sulfate and their interconversion.
Ira Schildkraut (29742) +7 more
core +1 more source
Life, 2023 Luciferases from copepods Metridia longa and Gaussia princeps are successfully used as bioluminescent reporters for in vivo and in vitro assays. Here, we report the minimal sequence of copepod luciferases required for bioluminescence activity that was ...
Svetlana V. Markova +3 more
doaj +1 more source
S-Series Coelenterazine-Driven Combinatorial Bioluminescence Imaging Systems for Mammalian Cells
International Journal of Molecular Sciences, 2023 A unique combinatorial bioluminescence (BL) imaging system was developed for determining molecular events in mammalian cells with various colors and BL intensity patterns.
Genta Kamiya +5 more
semanticscholar +1 more source
Creation of Artificial Luciferase 60s from Sequential Insights and Their Applications to Bioassays
Sensors, 2023 In this study, a series of new artificial luciferases (ALucs) was created using sequential insights on missing peptide blocks, which were revealed using the alignment of existing ALuc sequences.
Sung-Bae Kim +3 more
doaj +1 more source
Scheme for coelenterazine sulfate chemical synthesis.
, 2022 Scheme for coelenterazine sulfate chemical synthesis.
Ira Schildkraut (29742) +7 more
core +1 more source