Results 51 to 60 of about 7,015 (221)

A putative chordate luciferase from a cosmopolitan tunicate indicates convergent bioluminescence evolution across phyla

Scientific Reports, 2020
Pyrosomes are tunicates in the phylum Chordata, which also contains vertebrates. Their gigantic blooms play important ecological and biogeochemical roles in oceans. Pyrosoma, meaning “fire-body”, derives from their brilliant bioluminescence.
Michael Tessler, Jean P. Gaffney, Anderson G. Oliveira, Andrew Guarnaccia, Krista C. Dobi, Nehaben A. Gujarati, Moira Galbraith, Jeremy D. Mirza, John S. Sparks, Vincent A. Pieribone, Robert J. Wood, David F. Gruber   +11 more
doaj   +1 more source

Force field parameters for coelenterazine

, 2019
Force field parameters developed for coelenterazine as described in the manuscript "Atomistic insights into photoprotein formation: Computational prediction of the properties of coelenterazine and oxygen binding in Obelin" by Thomas M.
Haibo Yu (4397308), Thomas Griffiths (3359705), Aaron Oakley (2646646)   +2 more
core   +1 more source

Structure of coelenterazine.

, 2015
Structure of coelenterazine showing the incorporation of the amino acids phenylalanine and tyrosine.
Warren R. Francis (763154), Nathan C. Shaner (763155), Meghan L. Powers (763157), Steven H. D. Haddock (212203), Lynne M. Christianson (763156)   +4 more
core   +1 more source

BODIPY-coelenterazine conjugates as self-illuminating substrates for NanoLuc.

Chemical Communications
We report how the conjugation of coelenterazine (CTZ) to BODIPY retains its activity as a versatile substrate for luciferase-type enzymes opening the possibility of taking advantage of BODIPY's fluorescent properties and capacity to generate singlet ...
Valeska Viereckt, Frank Abendroth, Alexander Schauerte, M. Gerhard, C. Lichtenberg, Dmitri Kosenkov, Olalla Vázquez   +6 more
semanticscholar   +1 more source

Coelenterazine distribution and luciferase characteristics in oceanic decapod crustaceans

, 1995
Coelenterazine biosynthesis has recently been demonstrated in the developing eggs of the decapod Systellaspis debilis. The cellular source of coelenterazine and the potential for biosynthesis in adult decapods, however, have not been fully investigated ...
Herring, P. J., Thomson, Catherine M., Campbell, Anthony Keith   +2 more
core   +1 more source

Chemical structure of Coelenterazine and Cypridina luciferin.

, 2012
Chemical structure of Coelenterazine and Cypridina luciferin.
Ira Schildkraut (29742), Ezra Schildkraut (8680), George Tzertzinis (154499)   +2 more
core   +1 more source

Agonist‐specific conformational dynamics at the β2‐adrenoceptor dictate allosteric modulation of Gαs signalling and bronchodilation

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose β2‐adrenoceptor (β2AR) agonists are the cornerstone of asthma therapy and promote bronchodilation through Gαs signalling in airway smooth muscle (ASM), but their efficacy is limited by β‐arrestin‐mediated β2AR desensitization.
Sushrut D. Shah, Joshua Richard, Suvankar Ghosh, Jillian Jerwick, Joice T. Gavali, Raymond B. Penn, Alexander D. MacKerell Jr, Deepak A. Deshpande   +7 more
wiley   +1 more source

Symplectin evolved from multiple duplications in bioluminescent squid [PDF]

PeerJ, 2017
The squid Sthenoteuthis oualaniensis, formerly Symplectoteuthis oualaniensis, generates light using the luciferin coelenterazine and a unique enzyme, symplectin.
Warren R. Francis, Lynne M. Christianson, Steven H.D. Haddock   +2 more
doaj   +2 more sources

Introducing a new reporter gene, membrane-anchored Cypridina luciferase, for multiplex bioluminescence imaging

Molecular Therapy: Oncolytics, 2021
Bioluminescence reporter gene imaging is a robust, high-throughput imaging modality that is useful for tracking cells and monitoring biological processes, both in cell culture and in small animals.
Maxim A. Moroz, Juan Zurita, Anna Moroz, Ekaterina Nikolov, Yury Likar, Konstantin Dobrenkov, Jason Lee, Larissa Shenker, Ronald Blasberg, Inna Serganova, Vladimir Ponomarev   +10 more
doaj   +1 more source

The chemokine receptor‐like fourth extracellular loop of the apelin receptor differentially regulates apelin and elabela binding and signalling

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Apelin and Elabela are endogenous ligands of the apelin receptor (apelin receptor/APJ), a GPCR involved in cardiovascular regulation and body fluid homeostasis. The human receptor contains a conserved disulfide bridge linking the N‐terminal domain to extracellular loop 3 (ECL3) via Cys19 and Cys281, forming a structural ...
Chloé Bonef, Hela Bouhsine, Carine Huynh, Marion Chaigneau, Steven Dubois, Mikel Garcia‐Marcos, Catherine Llorens‐Cortes, Denis Servent, Philippe Robin, Hervé Nozach, Isabel Alves, Xavier Iturrioz   +11 more
wiley   +1 more source