Results 51 to 60 of about 5,761 (165)

Sulfakinin Signaling Sense Circulating Fructose and Suppresses Food Consumption via Insulin‐Like Peptide in Bactrocera Dorsalis

Advanced Science, Volume 13, Issue 29, 22 May 2026.
This study discovered a new pathway that tells fruit flies when to stop eating. It found that rising blood sugar (fructose) is detected by a sensor called GR43a. This triggers a chain reaction involving the satiety signal sulfakinin and its receptor, ultimately activating a final satiety signal, ILP5.
Hong‐Fei Li, Bao Dong, Zheng‐Lin Ren, Xue‐Guang Zhu, Quan Lei, Yoonseong Park, Jin‐Jun Wang, Hong‐Bo Jiang   +7 more
wiley   +1 more source

Bioluminescent Mammalian Cells Grown in Sponge Matrices to Monitor Immune Rejection

Molecular Imaging, 2007
The growth and bioluminescence of cells seeded in collagen and gelatin sponge matrices were compared in vitro under different conditions, and immune rejection was quantified and visualized directly in situ based on loss of bioluminescence activity ...
Okechukwu Ojogho, Alice Li, Craig W. Zuppan, Alan Escher   +3 more
doaj   +1 more source

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

Advanced Science, Volume 13, Issue 26, 8 May 2026.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu   +17 more
wiley   +1 more source

Light‐ and Bioluminescence‐Controlled Reversible Protein Conjugation on the Inner Leaflet of Asymmetric Phospholipid‐Amphiphilic Protein Hybrid Vesicles

ChemPlusChem, Volume 91, Issue 5, May 2026.
We established light‐ and bioluminescence‐responsive systems that allow reversible conjugation and dissociation of proteins on the inner leaflet of asymmetric lipid–amphiphilic protein hybrid vesicles. These systems provide a versatile platform for precise spatiotemporal regulation and bioluminescence‐triggered protein release within synthetic vesicles.
Masato Suzuki, Koki Kamiya
wiley   +1 more source

Bioluminescence Monitoring of Neuronal Activity in Freely Moving Zebrafish Larvae

Bio-Protocol, 2017
The proof of concept for bioluminescence monitoring of neural activity in zebrafish with the genetically encoded calcium indicator GFP-aequorin has been previously described (Naumann et al., 2010) but challenges remain.
Steven Knafo, Andrew Prendergast, Olivier Thouvenin, Sophie Figueiredo, Claire Wyart   +4 more
doaj   +1 more source

Profiling of HCAR1 signalling reveals Gαi/o and Gαs activation without β‐arrestin recruitment and the discovery of an allosteric agonist

British Journal of Pharmacology, Volume 183, Issue 10, Page 2219-2235, May 2026.
Abstract Background and Purpose Lactate, historically viewed as a metabolic by‐product, has emerged as a signalling molecule via the G protein–coupled receptor Hydroxycarboxylic Acid Receptor 1 (HCAR1). The receptor is primarily expressed in adipocytes but also found in various other tissues.
Simon Lind, Shane C. Wright, Emilia Gvozdenovic, Kristina Nilsson, Kenneth L. Granberg, Michel Bouvier, Linda C. Johansson   +6 more
wiley   +1 more source

A Computational Modeling of ADLumin Chemiluminescence: Oxygenation and Dioxetanone Formation

Journal of Computational Chemistry, Volume 47, Issue 11, 30 April 2026.
Chemiluminescent ADLumin molecules were studied using DFT to investigate their mechanisms of oxygenation and dioxetanone formation. Different oxygenation sites were explored for initiating competing reaction pathways that converge to the same 1,2‐dioxetanone intermediate.
Carly Wickizer, Chance Lander, Zheng Pei, Wai Tak Yip, Chongzhao Ran, Yihan Shao   +5 more
wiley   +1 more source

Biofabrication of Endothelialized, Intrinsically Vascularized 3D‐Printed Recombinant Spider Silk Scaffolds

Advanced Healthcare Materials, Volume 15, Issue 16, 24 April 2026.
This study evaluates 3D‐printed recombinant spider silk hydrogel eADF4(C16)‐RGD in a rat AV loop model for tissue engineering. Constructs with T17b endothelial progenitor cells showed enhanced vascularization and biodegradation. Results highlight the importance of scaffold design and cellular integration in improving vascular density and overall ...
Claire M. Weinhold, Stefanie Heltmann‐Meyer, Xuen J. Ng, Thomas Scheibel, Tobias Fey, Harald Wajant, Carol Geppert, Andreas Arkudas, Dominik Steiner, Raymund E. Horch   +9 more
wiley   +1 more source

ATP-Binding Cassette Transporters Modulate Both Coelenterazine- and D-Luciferin-Based Bioluminescence Imaging

Molecular Imaging, 2011
Bioluminescence imaging (BLI) of luciferase reporters provides a cost-effective and sensitive means to image biological processes. However, transport of luciferase substrates across the cell membrane does affect BLI readout intensity from intact living ...
Ruimin Huang, Jelena Vider, Inna Serganova, Ronald G. Blasberg   +3 more
doaj   +1 more source

Genetically Modified Coelenterazine-Dependent Luciferases as Reporters for In Vitro Assay [PDF]

Журнал Сибирского федерального университета: Серия Биология, 2017
Among the most important tasks of modern biotechnology is the development of new analytical techniques suitable for highly sensitive and specific detection of diagnostically important targets rapidly expanding their range with the progress in biomedical ...
Ludmila A. Frank, Eugenia E. Bashmakova, Vasilisa V. Krasitskaya, Alexander N. Kudryavtsev   +3 more
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