Results 81 to 90 of about 6,471 (200)
Comprehensive transduceromic profiling of NOP receptor ligands at different Gα subunits
British Journal of Pharmacology, Volume 183, Issue 12, Page 3195-3212, June 2026.Abstract Background and Purpose The nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) is an opioid receptor family member with distinct pharmacology and broad therapeutic potential. NOP receptors regulate functions such as nociception, stress reactivity, reward, mood, autonomic tone, immunity and sleep/wake cycle.
Davide Malfacini +9 more
wiley +1 more source
Molecular Imaging, 2011 Bioluminescence imaging (BLI) of luciferase reporters provides a cost-effective and sensitive means to image biological processes. However, transport of luciferase substrates across the cell membrane does affect BLI readout intensity from intact living ...
Ruimin Huang +3 more
doaj +1 more source
, 2016 (A) Schematic representation of the study design. (B) Blood glucose concentrations of vehicle control (white) and streptozotocin (black) treated mice (n = 4). (C) Images of a representative control and streptozotocin mouse imaged with coelenterazine. (D)
Laura L. Bronsart (844933) +2 more
core +1 more source
Comparative investigation into the anticancer activity of analogs of marine coelenterazine and coelenteramine [PDF]
Cancer is still one of the most challenging diseases to treat, making the pursuit for novel molecules with potential anticancer activity an important research topic.
González Berdullas, P +6 more
core +1 more source
Genetically Modified Coelenterazine-Dependent Luciferases as Reporters for In Vitro Assay [PDF]
Журнал Сибирского федерального университета: Серия Биология, 2017 Among the most important tasks of modern biotechnology is the development of new analytical techniques suitable for highly sensitive and specific detection of diagnostically important targets rapidly expanding their range with the progress in biomedical ...
Ludmila A. Frank +3 more
doaj
New bioluminescent coelenterazine derivatives with various C-6 substitutions
, 2017 A series of new coelenterazine analogs with varying substituents at the C-6 position of the imidazopyrazinone core have been designed and synthesized for the extension of bioluminescence substrates.
Tianyu Jiang +5 more
core +1 more source
A pH-sensitive closed-loop nanomachine to control hyperexcitability at the single neuron level
Nature CommunicationsEpilepsy affects 1% of the general population and 30% of patients are resistant to antiepileptic drugs. Although optogenetics is an efficient antiepileptic strategy, the difficulty of illuminating deep brain areas poses translational challenges.
Assunta Merolla +13 more
doaj +1 more source
Development of cell-impermeable coelenterazine derivatives
Chemical Science, 2013 We describe the development of the first cell-membrane impermeable coelenterazine derivative (CoelPhos). CoelPhos was constructed by the alkylation of coelenterazine with a linker containing a terminal anionic phosphonate moiety. The bioluminescence activity of CoelPhos with Gaussia luciferase (GLuc) showed a significantly higher activity in comparison
Eric Lindberg +5 more
openaire +2 more sources
International Journal of Nanomedicine, 2012 Qiang Wu, Maoquan ChuSchool of Life Science and Technology, Tongji University, Shanghai, People's Republic of ChinaAbstract: Quantum dots (QDs) show promise as novel nanomaterials for sentinel lymph node (SLN) mapping through their use in ...
Wu Q, Chu M
doaj
, 2019 Bioluminescence in marine systems is dominated by the use of coelenterazine for light production. The bioluminescent reaction of coelenterazine is an enzyme catalyzed oxidative decarboxylation: coelenterazine reacts with molecular oxygen to form carbon ...
Haibo Yu (19586578) +2 more
core +1 more source