Results 81 to 90 of about 7,015 (221)
Advanced Science, Volume 13, Issue 29, 22 May 2026.This study discovered a new pathway that tells fruit flies when to stop eating. It found that rising blood sugar (fructose) is detected by a sensor called GR43a. This triggers a chain reaction involving the satiety signal sulfakinin and its receptor, ultimately activating a final satiety signal, ILP5.
Hong‐Fei Li +7 more
wiley +1 more source
Advanced Science, Volume 13, Issue 26, 8 May 2026.We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin +17 more
wiley +1 more source
, 2022 Inhibition of luminescence activity of CTZ-utilizing luciferases with deaza-coelenterazine (daCTZ) analogs as inhibitors.
Mikako Shirouzu (272392) +7 more
core +1 more source
ChemPlusChem, Volume 91, Issue 5, May 2026.We established light‐ and bioluminescence‐responsive systems that allow reversible conjugation and dissociation of proteins on the inner leaflet of asymmetric lipid–amphiphilic protein hybrid vesicles. These systems provide a versatile platform for precise spatiotemporal regulation and bioluminescence‐triggered protein release within synthetic vesicles.
Masato Suzuki, Koki Kamiya
wiley +1 more source
Luciferase-Specific Coelenterazine Analogues for Optical Contamination-Free Bioassays
Scientific Reports, 2017 Spectral overlaps among the multiple optical readouts commonly cause optical contamination in fluorescence and bioluminescence. To tackle this issue, we created five-different lineages of coelenterazine (CTZ) analogues designed to selectively illuminate ...
Ryo Nishihara +5 more
doaj +1 more source
British Journal of Pharmacology, Volume 183, Issue 10, Page 2219-2235, May 2026.Abstract Background and Purpose Lactate, historically viewed as a metabolic by‐product, has emerged as a signalling molecule via the G protein–coupled receptor Hydroxycarboxylic Acid Receptor 1 (HCAR1). The receptor is primarily expressed in adipocytes but also found in various other tissues.
Simon Lind +6 more
wiley +1 more source
A Computational Modeling of ADLumin Chemiluminescence: Oxygenation and Dioxetanone Formation
Journal of Computational Chemistry, Volume 47, Issue 11, 30 April 2026.Chemiluminescent ADLumin molecules were studied using DFT to investigate their mechanisms of oxygenation and dioxetanone formation. Different oxygenation sites were explored for initiating competing reaction pathways that converge to the same 1,2‐dioxetanone intermediate.
Carly Wickizer +5 more
wiley +1 more source
Development of cell-impermeable coelenterazine derivatives
Chemical Science, 2013 We describe the development of the first cell-membrane impermeable coelenterazine derivative (CoelPhos). CoelPhos was constructed by the alkylation of coelenterazine with a linker containing a terminal anionic phosphonate moiety. The bioluminescence activity of CoelPhos with Gaussia luciferase (GLuc) showed a significantly higher activity in comparison
Eric Lindberg +5 more
openaire +2 more sources
, 2022 Cascade for conversion of coelenterazine sulfate to coelenteramide with concomitant emission of light utilizing PAP as the sulfate acceptor.
Ira Schildkraut (29742) +7 more
core +1 more source
Advanced Healthcare Materials, Volume 15, Issue 16, 24 April 2026.This study evaluates 3D‐printed recombinant spider silk hydrogel eADF4(C16)‐RGD in a rat AV loop model for tissue engineering. Constructs with T17b endothelial progenitor cells showed enhanced vascularization and biodegradation. Results highlight the importance of scaffold design and cellular integration in improving vascular density and overall ...
Claire M. Weinhold +9 more
wiley +1 more source