Results 91 to 100 of about 254,642 (354)
Advanced Science, EarlyView.This study reveals a citrate–ACLY–H3K27ac metabolic–epigenetic axis driving inflammatory gene activation and kidney fibrosis, highlighting ACLY inhibition as a potential therapeutic strategy for chronic kidney disease (CKD). ABSTRACT The mechanisms by which metabolic stress drives epigenetic dysregulation and fibrosis in chronic kidney disease (CKD ...
Chunxiu Du +15 more
wiley +1 more source
Cleavage of Coenzyme B12 by Methylmalonyl Coenzyme A Mutase
Journal of Biological Chemistry, 1973 Abstract Methylmalonyl-CoA mutase-dependent cleavage of coenzyme B12 took place in the presence of succinyl-CoA, one of the substrates of the enzyme, and in the presence of malonyl-CoA, a competitive inhibitor (Ki 0.12 mm). Other competitive inhibitors of the reaction, including acetyl-CoA, propionyl-CoA, glutaryl-CoA, and CoA itself, did not replace ...
B M, Babior, A D, Woodams, J D, Brodie
openaire +2 more sources
CoA protects against the deleterious effects of caloric overload in Drosophila [PDF]
, 2016 We developed a Drosophila model of T2D in which high sugar (HS) feeding leads to insulin resistance. In this model, adipose TG storage is protective against fatty acid toxicity and diabetes.
Baranski, Thomas J +2 more
core +2 more sources
Advanced Science, EarlyView.The integration of ROS‐generating systems with H2S depletion strategies effectively overcomes the limitations imposed by endogenous antioxidant defenses on ROS‐based antimicrobial therapies. In this study, the Cu‐MOF is incorporated into pillararene‐embedded COF, achieving a “three‐in‐one” antimicrobial effect that markedly alleviated periodontal ...
Shuang Liang +9 more
wiley +1 more source
A Case of Statin-Associated Autoimmune Myopathy. [PDF]
, 2017 A 70-year-old previously independent man developed progressive proximal leg weakness resulting in a fall at home suffering traumatic brain injury. He was prescribed a statin medication two years prior, but this was discontinued on admission to the ...
Dokukin, Andrei N +6 more
core +3 more sources
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Multiple Acyl‐CoA Dehydrogenase Deficiency (MADD) is an autosomal recessive inborn error of metabolism caused by biallelic pathogenic variants in one of three known genes: ETFA, ETFB, and ETFDH. It can cause multisystem dysfunction, including cardiomyopathy in severe cases.
Yutaka Furuta +17 more
wiley +1 more source
4′‐Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN
EMBO Molecular Medicine, 2019 Pantothenate kinase‐associated neurodegeneration (PKAN) is an inborn error of CoA metabolism causing dystonia, parkinsonism, and brain iron accumulation.
Suh Young Jeong +22 more
doaj +1 more source
Neurobiology of Disease, 2005 Neuronal cells depend on mitochondrial oxidative phosphorylation for most of their energy needs and therefore are at a particular risk for oxidative stress.
M. Somayajulu +5 more
doaj +1 more source
Evaluation of The Analgesic Activity of Coenzyme Q10 Ointment in Mice
Journal of Applied Veterinary Sciences, 2020 The aim of this study is to examine analgesic effect of Coenzyme Q10 ointment in mice. Fifteen healthy male albino mice were selected for this study. The animals were divided into three groups of five animals for each group.
Ibtisam T. Al-Jureisy +2 more
doaj +1 more source
Structural determination of archaeal UDP-N-acetylglucosamine 4-epimerase from Methanobrevibacter ruminantium M1 in complex with the bacterial cell wall intermediate UDP-N-acetylmuramic acid [PDF]
, 2018 The crystal structure of UDP-N-acetylglucosamine 4-epimerase (UDP-GlcNAc 4-epimerase; WbpP; EC 5.1.3.7), from the archaeal methanogen Methanobrevibacter ruminantium strain M1, was determined to a resolution of 1.65 Å. The structure, with a single monomer
Carbone, V +4 more
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