ACS Infectious Diseases, 2017 Previously, we showed that a major in vitro and in vivo mechanism of resistance to pyrazinoic acid (POA), the bioactive component of the critical tuberculosis (TB) prodrug pyrazinamide (PZA), involves missense mutations in the aspartate decarboxylase ...
Pooja Gopal +10 more
semanticscholar +1 more source
Functions of Coenzyme A and Acyl-CoA in Post-Translational Modification and Human Disease
Frontiers in Bioscience-LandmarkCoenzyme A (CoA) is synthesized from pantothenate, L-cysteine and adenosine triphosphate (ATP), and plays a vital role in diverse physiological processes. Protein acylation is a common post-translational modification (PTM) that modifies protein structure,
Jumin Xie +4 more
doaj +1 more source
Clinical syndromes associated with Coenzyme Q10 deficiency. [PDF]
, 2018 Primary Coenzyme Q deficiencies represent a group of rare conditions caused by mutations in one of the genes required in its biosynthetic pathway at the enzymatic or regulatory level.
Alc\ue1zar-Fabra, Maria +2 more
core +1 more source
The Metabolism of Coenzyme A and Its Derivatives Plays a Crucial Role in Diseases
Frontiers in Bioscience-LandmarkCoenzyme A (CoA) functions as a crucial carrier of acyl groups within cells, playing a fundamental role in regulating acyl transfer reactions and participating in cellular metabolic processes.
Jumin Xie +4 more
doaj +1 more source
Insights into molecular mechanisms of disease in Neurodegeneration with Brain Iron Accumulation; unifying theories. [PDF]
, 2016 Neurodegeneration with brain iron accumulation (NBIA) is a group of disorders characterised by dystonia, parkinsonism and spasticity. Iron accumulates in the basal ganglia and may be accompanied by Lewy bodies, axonal swellings and hyperphosphorylated ...
Adibhatla +148 more
core +1 more source
Determination of quantum yield of NADH and FAD in alcohol-water solutions: the analysis of radiative and nonradiative relaxation pathways [PDF]
arXiv, 2022 Combined studies on fluorescence quantum yield in coenzymes NADH and FAD in water-methanol, water-ethanol and water-propylene glycol mixtures and on time-resolved fluorescence of the same molecules under excitation at 450 and 355~nm by means of the TCSPC method have been carried out.
arxiv
Shapes and Positions of Black Hole Shadows in Accretion Disks and Spin Parameters of Black Holes [PDF]
J.Korean Phys.Soc.45:S1808-S1812,2004;
Astrophys.J.611:996-1004,2004, 2004 Can we determine a spin parameter of a black hole by observation of a black hole shadow in an accretion disk? In order to answer this question, we make a qualitative analysis and a quantitative analysis of a shape and a position of a black hole shadow casted by a rotating black hole on an optically thick accretion disk and its dependence on an angular ...
arxiv +1 more source
Frontiers in Physiology, 2017 Coenzyme Q is a lipid that participates to important physiological functions. Coenzyme Q is synthesized in multiple steps from the precursor 4-hydroxybenzoic acid.
Fabien Pierrel
doaj +1 more source
Evaluation of coenzyme Q10 addition and storage temperature on some physicochemical and organoleptic properties of pomegranate juice [PDF]
, 2013 Today, in parallel to growing in acceptance of functional products, various additives are used to improve the characteristics of functional food products. The coenzyme Q10 plays a vital role in cellular energy production.
Goudarzi, Zahra +3 more
core +2 more sources
Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis
ACS Infectious Diseases, 2016 Mycobacterium tuberculosis relies on its own ability to biosynthesize coenzyme A to meet the needs of the myriad enzymatic reactions that depend on this cofactor for activity.
Joanna C. Evans +9 more
semanticscholar +1 more source