Results 21 to 30 of about 129,225 (257)

Coenzyme a Biochemistry: From Neurodevelopment to Neurodegeneration

open access: yesBrain Sciences, 2021
Coenzyme A (CoA) is an essential cofactor in all living organisms. It is involved in a large number of biochemical processes functioning either as an activator of molecules with carbonyl groups or as a carrier of acyl moieties.
Luca Mignani   +3 more
doaj   +1 more source

Functions of Coenzyme A and Acyl-CoA in Post-Translational Modification and Human Disease

open access: yesFrontiers in Bioscience-Landmark
Coenzyme A (CoA) is synthesized from pantothenate, L-cysteine and adenosine triphosphate (ATP), and plays a vital role in diverse physiological processes. Protein acylation is a common post-translational modification (PTM) that modifies protein structure,
Jumin Xie   +4 more
doaj   +1 more source

Characterization of Plasmodium falciparum Pantothenate Kinase and Identification of Its Inhibitors From Natural Products

open access: yesFrontiers in Cellular and Infection Microbiology, 2021
Coenzyme A (CoA) is a well-known cofactor that plays an essential role in many metabolic reactions in all organisms. In Plasmodium falciparum, the most deadly among Plasmodium species that cause malaria, CoA and its biosynthetic pathway have been proven ...
Arif Nurkanto   +15 more
doaj   +1 more source

The Metabolism of Coenzyme A and Its Derivatives Plays a Crucial Role in Diseases

open access: yesFrontiers in Bioscience-Landmark
Coenzyme A (CoA) functions as a crucial carrier of acyl groups within cells, playing a fundamental role in regulating acyl transfer reactions and participating in cellular metabolic processes.
Jumin Xie   +4 more
doaj   +1 more source

Isolating promoters from Corynebacterium ammoniagenes ATCC 6871 and application in CoA synthesis

open access: yesBMC Biotechnology, 2019
Background Corynebacterium ammoniagenes is an important industrial organism that is widely used to produce nucleotides and the potential for industrial production of coenzyme A by C. ammoniagenes ATCC 6871 has been shown. However, the yield of coenzyme A
Yingshuo Hou   +5 more
doaj   +1 more source

Analysis of the mechanosensor channel functionality of TACAN

open access: yeseLife, 2021
Mechanosensitive ion channels mediate transmembrane ion currents activated by mechanical forces. A mechanosensitive ion channel called TACAN was recently reported.
Yiming Niu   +6 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

A cross-metathesis approach to novel pantothenamide derivatives

open access: yesBeilstein Journal of Organic Chemistry, 2016
Pantothenamides are known for their in vitro antimicrobial activity. Our group has previously reported a new stereoselective route to access derivatives modified at the geminal dimethyl moiety.
Jinming Guan   +5 more
doaj   +1 more source

Involvement of ACSL in local synthesis of neutral lipids in cytoplasmic lipid droplets in human hepatocyte HuH7

open access: yesJournal of Lipid Research, 2007
Lipid droplets (LDs) function as intracellular storage depots of neutral lipids. Recently, we identified long-chain acyl-coenzyme A synthetase 3 (ACSL3) as a major LD-associated protein in the human hepatocyte cell line HuH7.
Yasuyuki Fujimoto   +10 more
doaj   +1 more source

Isolation of an Enzyme-Coenzyme A Intermediate from Succinyl Coenzyme A-Acetoacetate Coenzyme A Transferase

open access: yesJournal of Biological Chemistry, 1967
Abstract An alkali-labile enzyme-coenzyme A intermediate has been isolated by molecular exclusion chromatography of succinyl-CoA-acetoacetate coenzyme A transferase after incubation with acetoacetyl-CoA or succinyl-CoA. Treatment of the intermediate with tritium-labeled sodium borohydride results in enzyme inactivation and incorporation of ...
L B, Hersh, W P, Jencks
openaire   +2 more sources

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