Results 41 to 50 of about 148,184 (310)

Effects of myosin heavy chain (MHC) plasticity induced by HMGCoA-reductase inhibition on skeletal muscle functions. [PDF]

, 2011
The rate-limiting step of cholesterol biosynthetic pathway is catalyzed by 3-hydroxy-3-methylglutaryl coenzyme reductase (HGMR), whose inhibitors, the statins, widely used in clinical practice to treat hypercholesterolemia, often cause myopathy, and ...
Moreno, Sandra, Swiezewska, Ewa, Linari, Marco, Fanelli, Francesca, V. Trezza, Segatto, Marco, L. Melli, Marco Segatto, L. p. Pucillo, Patrizia Campolongo, Pallottini, Valentina, Laura Trapani, Leopoldo Paolo Pucillo, Viviana Trezza, S. Moreno, F. Fanelli, A. Jozwiak, M. Segatto, V. Pallottini, Campolongo, Patrizia, Melli, Luca, Sandra Moreno, Francesca Fanelli, Marco Linari, Trezza, Viviana, E. Swiezewska, L. Trapani, Trapani, Laura, Valentina Pallottini, Adam Jozwiak, Luca Melli, Ewa Swiezewska, Jóźwiak, Adam, M. Linari, Pucillo, Leopoldo Paolo   +34 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Coenzyme A in Brain Biology and Neurodegeneration

Biomedicines
Coenzyme A (CoA) biology has been extensively studied in health and disease due to the central role of CoA in numerous metabolic and signalling processes.
Dejun Zhang, Charlie Brett, Jason Cho, Tammaryn Lashley, Ivan Gout   +4 more
doaj   +1 more source

Coenzyme Q10 ameliorates BPA-induced apoptosis by regulating autophagy-related lysosomal pathways

Ecotoxicology and Environmental Safety, 2021
Bisphenol A (BPA) is a widely distributed environmental endocrine disruptor. The accumulation of BPA has been proved that produce various toxic effects both on human and animals. However, the strategies to reduce the damage of BPA on the body and related
Yuan Liu, Yaxin Yao, Wenjing Tao, Feng Liu, Songbai Yang, Ayong Zhao, Dan Song, Xiangchen Li   +7 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Effect of Dietary Coenzyme Q10 on Cholesterol Metabolism in Growing Chickens

The Journal of Poultry Science, 2010
Coenzyme Q10 (CoQ10), a potent lipophilic antioxidant, is a naturally occurring compound with a ubiquitous distribution in nature and is used as a dietary supplement to combat aging.
Kazuhisa Honda, Hiroshi Kamisoyama, Tomoki Motoori, Takaoki Saneyasu, Shin Hasegawa   +4 more
doaj   +1 more source

A randomized controlled trial of coenzyme Q10 for fatigue in the late-onset sequelae of poliomyelitis

, 2015
Objective: To determine if coenzyme Q10 alleviates fatigue in the late-onset sequelae of poliomyelitis. Design: Parallel-group, randomized, placebo-controlled trial.
Cooke, Marie, Lewis-Peel, Helen J, Peel, Margaret, Peel, Margaret M, Lea, Rodney, Lea, Rodney A., Lewis-Peel, Helen, Moyle, Wendy, Lewis-Peel, Helen J., Peel, Margaret M., Lea, Rodney A   +10 more
core   +1 more source

Photochromic Coenzyme Q Derivatives: Switching Redox Potentials with Light [PDF]

, 2017
Coenzyme Q is an important redox cofactor involved in a variety of cellular processes, and thus found in several cell compartments. We report a photochromic derivative of coenzyme Q that combines the molecular structures of the redox active cofactor and ...
Andrea C. Kneuttinger, Burkhard König, Reinhard Sterner, Simeth, Nadja A., Simeth, Nadja Anita, König, Burkhard, Nadja A. Simeth, Kneuttinger, Andrea C., Sterner, Reinhard   +8 more
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Coenzyme A and its derivatives: renaissance of a textbook classic

, 2014
In 1945, Fritz Lipmann discovered a heat-stable cofactor required for many enzyme-catalysed acetylation reactions. He later determined the structure for this acetylation coenzyme, or coenzyme A (CoA), an achievement for which he was awarded the Nobel ...
Theodoulou, Frederica L., Sibon, Ody C. M., Theodoulou, F. L., Jackowski, S., Gout, Ivan, Sibon, Ody C. M.; id_orcid, Gout, I., Jackowski, Suzanne, Sibon, O. C. M.   +8 more
core   +1 more source