Results 61 to 70 of about 25,277,741 (360)
Comprehensive behavioral testing in the R6/2 mouse model of Huntington's disease shows no benefit from CoQ10 or minocycline [PDF]
, 2010 Previous studies of the effects of coenzyme Q10 and minocycline on mouse models of Huntington’s disease have produced conflicting results regarding their efficacy in behavioral tests.
Allan J. Tobin +13 more
core +3 more sources
Molecular Oncology, EarlyView.NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi +5 more
wiley +1 more source
Metabolic Targets of Coenzyme Q10 in Mitochondria
Antioxidants, 2021 Coenzyme Q10 (CoQ10) is classically viewed as an important endogenous antioxidant and key component of the mitochondrial respiratory chain. For this second function, CoQ molecules seem to be dynamically segmented in a pool attached and engulfed by the ...
A. Hidalgo-Gutiérrez +6 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan +10 more
wiley +1 more source
Effect of Dietary Coenzyme Q10 on Cholesterol Metabolism in Growing Chickens
The Journal of Poultry Science, 2010 Coenzyme Q10 (CoQ10), a potent lipophilic antioxidant, is a naturally occurring compound with a ubiquitous distribution in nature and is used as a dietary supplement to combat aging.
Kazuhisa Honda +4 more
doaj +1 more source
Neuroprotective Effect of Coenzyme Q10 in Hippocampal Injury in Balb/c Mouse [PDF]
, 2014 Coenzyme Q10 is a promising agent for neuroprotection in neurodegenerative diseases. Neuroprotective effects of Coenzyme Q10 demonstrated in some neurodegenerative diseases such as Parkinson, Alzheimer and etc.
Alizadeh, Akram. +7 more
core
Oncometabolites: tailoring our genes [PDF]
, 2015 Increased glucose metabolism in cancer cells is a phenomenon that has been known for over 90 years, allowing maximal cell growth through faster ATP production and redistribution of carbons towards nucleotide, protein and fatty acid synthesis.
Avril N, Buck AC, Gimm O, Higashi K
core +1 more source
Regulating Protein Immobilization During Cell‐Free Protein Synthesis in Hyaluronan Microgels
Advanced Biology, EarlyView.Bifunctional microgels carrying a linear DNA template and Ni2+‐activated NTA moieties are used as platform for cell‐free protein synthesis and in situ protein immobilization. By varying the concentration of NTA moieties in the microgels, the amount of GFP‐His immobilized inside the microgel and released to the microgel environment can be regulated ...
Anika Kaufmann +2 more
wiley +1 more source
The BM@N spectrometer at the NICA accelerator complex [PDF]
arXiv, 2023 BM@N (Baryonic Matter at Nuclotron) is the first experiment operating and taking data at the Nuclotron/NICA ion-accelerating complex.The aim of the BM@N experiment is to study interactions of relativistic heavy-ion beams with fixed targets. We present a technical description of the BM@N spectrometer including all its subsystems.
arxiv
The Roles of Coenzyme Q in Disease: Direct and Indirect Involvement in Cellular Functions
International Journal of Molecular Sciences, 2021 Coenzyme Q (CoQ) is a key component of the respiratory chain of all eukaryotic cells. Its function is closely related to mitochondrial respiration, where it acts as an electron transporter.
Francesco Pallotti +3 more
semanticscholar +1 more source