Results 81 to 90 of about 136,670 (296)

Interaktomanalyse einer Lysindeacetylase‐Sondenbibliothek deckt Wechselwirkung zwischen HDAC6 und dem NF‐κB‐Signalweg auf

Angewandte Chemie, EarlyView.
Wir haben eine Peptidsondenbibliothek entwickelt, die auf Substraten der Lysindeacetylase HDAC6 und Hydroxamsäuren basiert. Mit Hilfe dieser konnten wir durch Interaktomanalysen neue HDAC6‐Interaktoren identifizieren. Unter ihnen befand sich der Transkriptionsfaktor NF‐κB, wobei wir zeigen konnten, dass HDAC6 der Aktivität von acetyliertem NF‐κB p50 ...
Julian Seidel, Caroline Schönfeld, Julia Sindlinger, Jürgen Eirich, Sören Kirchgäßner, Nina Kreienkamp, Klaus Schulze‐Osthoff, Iris Finkemeier, Stephan Hailfinger, Dirk Schwarzer   +9 more
wiley   +1 more source

The tryptophanase-tryptophan reaction. The nature of the enzyme-coenzyme-substrate complex [PDF]

, 1954
Harry Gooder, F. C. Happold
openalex   +1 more source

Coenzyme Q10 Deficiency [PDF]

Deutsches Ärzteblatt international, 2016
The prevalence of dyslipidemia is high. It is usually treated with statins which inhibit HMG-CoA reductase and also coenzyme Q10 synthesis. This may lead to muscle pain. The question whether coenzyme Q10 replacement treatment helps to improve these muscle symptoms has been evaluated in a prospective study.
openaire   +3 more sources

Interactome Profiling of a Lysine Deacetylase Trapping Probe Library Uncovers Crosstalk Between HDAC6 and NF‐κB Signaling

Angewandte Chemie International Edition, EarlyView.
We designed a peptide probe library containing hydroxamic acids based on putative substrate sites of lysine deacetylase HDAC6. Analyzing substrate selectivity and turnover combined with proteomics profiling resulted in identification of novel HDAC6 interaction partners, such as components of the transcription factor NF‐κB.
Julian Seidel, Caroline Schönfeld, Julia Sindlinger, Jürgen Eirich, Sören Kirchgäßner, Nina Kreienkamp, Klaus Schulze‐Osthoff, Iris Finkemeier, Stephan Hailfinger, Dirk Schwarzer   +9 more
wiley   +1 more source

Efficacy of coenzyme Q10 in patients with cardiac failure: a meta-analysis of clinical trials

BMC Cardiovascular Disorders, 2017
Background The therapeutic efficacy of coenzyme Q10 on patients with cardiac failure remains controversial. We pooled previous clinical studies to re-evaluate the efficacy of coenzyme Q10 in patients with cardiac failure.
Li Lei, Yan Liu
doaj   +1 more source

Metabolomic analysis reveals the molecular mechanism related to leg abnormality in broilers

Animal Research and One Health, EarlyView.
The graphical abstract shows the principal results of this study. Compared to the leg normal broilers, the serum calcium to phosphorus ratio was extremely decreased in the group with deformed leg bones. Additionally, a total of nine differential metabolites significantly associated with leg abnormalities and serum calcium and phosphorus levels were ...
Jumei Zheng, Qi Zhang, Xinxin Tang, Fan Ying, Dawei Liu, Sen Li, Ranran Liu, Jie Wen, QingHe Li, Guiping Zhao   +9 more
wiley   +1 more source

Exploring the Roles of Tuna‐Associated Acinetobacter sp. YFT067: Implications for Host Health and Metabolism

Animal Research and One Health, EarlyView.
This study firstly isolated a tuna‐derived gut probiotic Acinetobacter seifertii YFT067. Dietary administration of YFT067 played significant roles in promoting growth performance, SCFAs production, lipid absorption, and metabolism of the host, indicating YFT067 as a promising probiotic candidate for enhancing tuna aquaculture productivity through ...
Ying Zou, Hai Huang, Qiongyao Fu, Zhiyuan Lu, Zhiqiang Guo   +4 more
wiley   +1 more source

Characterization of the pattern of development of key compounds contributing to aroma quality of chicken meat and their metabolic markers

Animal Research and One Health, EarlyView.
The graphical abstract shows the principal results of this study. Eight major aroma‐contributing compounds (nonanal, octanal, dimethyl tetrasulfide, hexanal, 1‐octen‐3‐ol, (E)‐2‐nonenal, heptanal, and (E,E)‐2,4‐decadienal) were identified by electronic nose and GC‐O‐MS analysis, and their content increased with age.
Yanke Wang, Xiaojing Liu, Yongli Wang, Zhengxiao He, Guiping Zhao, Jie Wen, Huanxian Cui   +6 more
wiley   +1 more source

Regulation of Chondrocyte Metabolism and Osteoarthritis Development by Sirt5 Through Protein Lysine Malonylation

Arthritis &Rheumatology, EarlyView.
Objective Chondrocytemetabolic dysfunction plays an important role in osteoarthritis (OA) development during aging and obesity. Protein posttranslational modifications (PTMs) have recently emerged as an important regulator of cellular metabolism. We aim to study one type of PTM, lysine malonylation (MaK), and its regulator sirtuin 5 (Sirt5) in OA ...
Huanhuan Liu, Anupama Binoy, Siqi Ren, Thomas C. Martino, Anna E. Miller, Craig R. G. Willis, Shivakumar R. Veerabhadraiah, Joanna Bons, Jacob P. Rose, Birgit Schilling, Michael J. Jurynec, Shouan Zhu   +11 more
wiley   +1 more source

Antiphospholipid Syndrome: An Antibody‐Mediated Disease With Emerging Therapeutic Opportunities

Arthritis &Rheumatology, EarlyView.
Antiphospholipid syndrome (APS) is an autoimmune thromboinflammatory disease characterized by vascular thrombosis, pregnancy morbidity, and other manifestations driven by antiphospholipid autoantibodies. In this review, we present a clinical case that illustrates some diagnostic and therapeutic challenges in managing severe, relapsing APS ...
Thalia G. Newman, Jason S. Knight
wiley   +1 more source