Results 111 to 120 of about 34,301 (245)

Contributions of synaptic energetic dysfunction by microtubule dynamics and microtubule‐based mitochondrial transport disorder to morphine tolerance

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Morphine is among the most powerful analgesic, but its long‐term use can cause tolerance. Synaptic ATP supply is critical for maintaining synaptic transmission. Microtubule‐based mitochondrial transport ensures synaptic energy supply.
Zheng Li, Jie Liu, Jie Ju, Xiaoling Peng, Wei Zhao, Jihao Ren, Xiaoqian Jia, Jihong Wang, Ye Tu, Feng Gao   +9 more
wiley   +1 more source

Is Inflammation a Mitochondrial Dysfunction-Dependent Event in Fibromyalgia? [PDF]

, 2013
Fibromyalgia (FM) is a complex disorder that affects up to 5% of the general population worldwide. Both mitochondrial dysfunction and inflammation have been implicated in the pathophysiology of FM.
Alfonsi, Simona, Bullon, Pedro, Carrión, Ángel Manuel, Cordero, Mario D., Díaz-Parrado, Eduardo, Sánchez Alcázar, José Antonio   +5 more
core  

Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes with recurrent abdominal symptoms and coenzyme Q10 administration. [PDF]

, 1987
Mamoru Yamamoto, Takeshi Sato, Midori Anno, Hiroshi Ujike, Minoru Takemoto   +4 more
openalex   +1 more source

Effects of HMG CoA reductase (HMGCR) deficiency on skeletal muscle development

The FEBS Journal, EarlyView.
Three skeletal muscle diseases are linked to HMGCR, a key enzyme in cholesterol synthesis. These diseases include a muscular dystrophy associated with pathogenic variants in the HMGCR gene, statin‐associated myopathy, and autoimmune anti‐HMGCR myopathy.
Mekala Gunasekaran, Hannah R. Littel, Natalya M. Wells, Johnnie Turner, Gloriana Campos, Sree Venigalla, Elicia A. Estrella, Partha S. Ghosh, Audrey L. Daugherty, Seth A. Stafki, Louis M. Kunkel, A. Reghan Foley, Sandra Donkervoort, Carsten G. Bönnemann, Laura Toledo‐Bravo de Laguna, Andres Nascimento, Daniel Natera‐de Benito, Isabelle Draper, Christine C. Bruels, Christina A. Pacak, Peter B. Kang   +20 more
wiley   +1 more source

The molecular mechanisms of defensive‐grade organic acid biosynthesis in ground beetles

Insect Molecular Biology, EarlyView.
Formic acid and methacrylic acid are the primary defensive chemicals in the pygidial gland secretions of Platynus angustatus and Pterostichus moestus, respectively. Comparative transcriptomics suggests the folate cycle and valine catabolism may be involved in the biosynthesis of formic acid and methacrylic acid, respectively.
Adam M. Rork, Sihang Xu, Athula Attygalle, Tanya Renner   +3 more
wiley   +1 more source

Coenzyme Q10 and pro-inflammatory markers in children with Down syndrome: clinical and biochemical aspects

Jornal de Pediatria (Versão em Português), 2017
Objective: Evidence of oxidative stress was reported in individuals with Down syndrome. There is a growing interest in the contribution of the immune system in Down syndrome.
Moushira E. Zaki, Hala T. El-Bassyouni, Angie M.S. Tosson, Eman Youness, Jihan Hussein   +4 more
doaj   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Groeger Sabine Elisabeth, Zhou Yuxi, Yong Jiawen, Wang Lei, Ruf Sabine, Meyle Joerg   +5 more
wiley   +1 more source

Therapeutic Role of Probiotics for the Treatment of Dyspepsia: A Review of the Literature

Neurogastroenterology &Motility, EarlyView.
Recent studies suggest that microbiota imbalance plays a significant role in the development of functional dyspepsia (FD). Specifically, patients with FD have shown increased levels of Streptococcus and decreased levels of Prevotella, Veillonella, and Actinomyces.
Giovanni Marasco, Miriam Fiocca, Cesare Cremon, Luigi Colecchia, Marcello Maida, Elton Dajti, Maria Raffaella Barbaro, Vincenzo Stanghellini, Giovanni Barbara   +8 more
wiley   +1 more source

Platelets Mitochondrial Function Depends on Coenzyme Q10 Concentration in Human Young, Not in Elderly Subjects [PDF]

, 2019
Ageing is characterized by a progressive decline in the physiological functions of various organs. Mitochondrial alterations occurring in senescence.
Chládeková, Anežka, Gvozdjáková, Anna, Kubalová, Mária, Kucharská, Jarmila, Kuzmiaková, Zuzana, Mojto, Viliam, Nemec, Michal, Rausová, Zuzana, Sumbalová, Zuzana, Ulicná, Olga, Vancová, Olga   +10 more
core   +1 more source

Plant‐derived vesicle‐like nanoparticles in food crops: emerging insights into nutritional biofortification and biomedical applications

Plant Biotechnology Journal, EarlyView.
Summary Food crops, as the cornerstone of human nutrition, not only provide essential macronutrients but also encompass a rich spectrum of bioactive compounds that promote health. Of particular significance are underutilized minor crops, which contain unique beneficial components with proven nutraceutical properties. These valuable bioactive components
Jie Wang, Zhaosheng Kong
wiley   +1 more source