Results 121 to 130 of about 96,183 (271)

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Effects of coenzyme Q10 on the heart ultrastructure and nitric oxide synthase during hyperthyroidism [PDF]

, 2021
Coenzyme Q10 is an important component of mitochondrial electron transport chain and antioxidant. Hyperthyroidism manifests hyperdynamic circulation with increased cardiac output, increased heart rate and decreased peripheral resistance.
Ergin, Bulent, Demirci, Cihan, Caner, Metin, Oztay, Füsün, Kapucu, Ayşegül, Ustunova, Savas, Balci, Huriye   +6 more
core  

CoQ10 mitigates BPA-induced cardiotoxicity by maintaining cellular antioxidant levels and Na+/K+-ATPase and Ca2+-ATPase activities

Scientific African
Background: Bisphenol A is an endocrine disruptor widely used by humans, and has diverse toxic effects, such as cardiotoxicity. The cardiotoxic effect of Bisphenol A is multifaceted and includes the depletion of cellular antioxidants and impairment of Na+
W.A. Saka, A.A. Oladipo, C.A. Adegbola, O.E. Adelowo, P.A. Oyedokun, O.R. Kolawole, M.T. Owoeye, T.M. Akhigbe, A.Y. Onaolapo, R.E. Akhigbe   +9 more
doaj   +1 more source

Expanding Spectrum of FIG4‐Related Neurological Disorders of Lysosomal Homeostasis: Case Report and Overview of the Potential Genotype–Phenotype Correlations

Clinical Genetics, EarlyView.
FIG4 is essential for lysosomal homeostasis. FIG4‐related disorders present as a continuous spectrum from the juvenile lethality in Yunis‐Varon syndrome to an increased risk of amyotrophic lateral sclerosis (ALS) in adult life. FIG4‐related disorders comprise a novel group of disorders of lysosomal homeostasis and can be classified into severe ...
Pankaj Prasun, Matthew Rasberry
wiley   +1 more source

Protective effect of coenzyme Q10 against neomycin-induced cell death. [PDF]

, 2014
Utricles were cultured for 24 h without neomycin (a, b), with neomycin (c, d) or with both neomycin and coenzyme Q10 (e–h). Death of striolar hair cells (red: calbindin) and extrastriolar hair cells (green: calmodulin) was inhibited by coenzyme Q10.
Yoshinobu Hirose (635936), Makoto Hashimoto (7130), Hirotaka Hara (635939), Eiju Kanagawa (635938), Kazuma Sugahara (635935), Hiroaki Shimogori (635940), Hiroshi Yamashita (255867), Takefumi Mikuriya (635937)   +7 more
core   +1 more source

THE ANTI-CATARACT EFFECT OF COENZYME Q10 IN RABBITS [PDF]

, 2017
Objective: cataract is the opacity of the lens which progressively impairs the light transmission to the retina and finally prevents the vision, these opacity result from the oxidative process in the eye. The study aimed to prevent opacity of the lens by
Ahmed Salim Mahmood, Baha'a A. Abdul Hussein   +1 more
core   +4 more sources

Nanoemulsion structure and food matrix determine the gastrointestinal fate and in vivo bioavailability of coenzyme Q10.

Journal of Controlled Release, 2020
In this work, we sought to incorporate coenzyme Q10-loaded nanoemulsions into a food system and to understand the impact of food digestion on the in vivo bioavailability of this bioactive compound.
Zhigao Niu, Alejandra Acevedo-Fani, A. McDowell, Alicia M. Barnett, S. Loveday, Harjinder Singh   +5 more
semanticscholar   +1 more source

Diagnostic Yield and Clinical Impact of Comprehensive WES/WGS Testing Beyond Common Genetic Causes in Hereditary Optic Atrophy

Clinical Genetics, EarlyView.
Opticus atrophy—Genetic testing with WES/WGS in 62 patients with optic atrophy provided a genetic diagnosis in 21 patients (33.9%). 42.9% of these involved non‐OPA1 genes, including WFS1, ACO2, NR2F1, UCHL1, CACNA1F, and COQ2, where the genetic diagnosis prompted additional clinical evaluation, surveillance, or therapeutic intervention.
Katrine M. Johannesen, Karen Grønskov, Line Kessel, Sarah Linea von Holstein, Lisbeth Birk Møller, Mette Kjøbæk Gundestrup Andersen, Marianne Søndergaard Khinchi, Steffen Hamann, Marianne Wegener, Mette Bertelsen   +9 more
wiley   +1 more source

Effects of Oral, Vaginal, and Transdermal Hormonal Contraception on Serum Levels of Coenzyme Q10, Vitamin E, and Total Antioxidant Activity

Obstetrics and Gynecology International, 2010
The use of the transdermal contraceptive patch is associated with greater bioavailability of ethinyl estradiol (EE) compared with contraceptive vaginal ring or oral contraceptives (OC).
Prabhudas R. Palan, Felix Strube, Juraj Letko, Azra Sadikovic, Magdy S. Mikhail   +4 more
doaj   +1 more source

Coenzyme Q10 supplementation of human oocyte in vitro maturation reduces postmeiotic aneuploidies.

Fertility and Sterility, 2020
OBJECTIVE To evaluate the effect of coenzyme Q10 (CoQ10) supplementation on oocyte maturation rates and postmeiotic aneuploidy rates during in vitro maturation (IVM) of human oocytes. DESIGN Clinical laboratory observation.
Long Ma, Ling-bo Cai, Mengting Hu, Jing Wang, Jiazi Xie, Yan Xing, Jiandong Shen, Yugui Cui, X. J. Liu, Jiayin Liu   +9 more
semanticscholar   +1 more source