Results 121 to 130 of about 80,404 (288)
A narrative literature review about alpha‐lipoic acid role in dry eye and ocular surface disease
Acta Ophthalmologica, EarlyView.Abstract Ocular surface diseases (OSD) include various conditions that affect the eye's surface, causing discomfort and pain. One such condition, dry eye disease (DED), is a multifactorial disorder that significantly impacts patients' quality of life, with prevalence rates ranging from 5% to 50% and higher incidence in women.
Antonio J. Mateo Orobia +4 more
wiley +1 more source
Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors
British Journal of Pharmacology, EarlyView.Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen +3 more
wiley +1 more source
STATINS AND MYOPATHY: MOLECULAR MECHANISMS
Рациональная фармакотерапия в кардиологии, 2015 The safety of statin therapy is considered. In particular the reasons of a complication such as myopathy are discussed in detail. The molecular mechanisms of statin myopathy , as well as its risk factors are presented.
O. M. Drapkina +2 more
doaj +3 more sources
Медицинский совет, 2019 The research objective consisted in studying of influence of coenzyme Q10 as a part of complex therapy of patients with the chronic heart failure (CHF) on indicators of quality of life in comparison with traditional therapy without coenzyme Q10 addition.
Zh. M. Sizova +2 more
doaj +1 more source
Effects of HMG CoA reductase (HMGCR) deficiency on skeletal muscle development
The FEBS Journal, EarlyView.Three skeletal muscle diseases are linked to HMGCR, a key enzyme in cholesterol synthesis. These diseases include a muscular dystrophy associated with pathogenic variants in the HMGCR gene, statin‐associated myopathy, and autoimmune anti‐HMGCR myopathy.
Mekala Gunasekaran +20 more
wiley +1 more source
The molecular mechanisms of defensive‐grade organic acid biosynthesis in ground beetles
Insect Molecular Biology, EarlyView.Formic acid and methacrylic acid are the primary defensive chemicals in the pygidial gland secretions of Platynus angustatus and Pterostichus moestus, respectively. Comparative transcriptomics suggests the folate cycle and valine catabolism may be involved in the biosynthesis of formic acid and methacrylic acid, respectively.
Adam M. Rork +3 more
wiley +1 more source
International Journal of Environmental Research and Public Health, 2019 Heavy metal exposure, in lead (Pb) particularly, is associated with severe neuronal impairment though oxidative stress mediated by reactive oxygen species, and antioxidants may be used to abolish these adverse effects.
Al Omar S Yousef +5 more
semanticscholar +1 more source
Two cases of neonatal hyperglycemia caused by a homozygous COQ9 stop‐gain variant
Journal of Diabetes Investigation, EarlyView.ABSTRACT Neonatal diabetes mellitus (NDM) is a monogenic condition diagnosed <6 months of age with >40 genetic causes. International guidelines recommend referral for genetic testing immediately after diagnosis since the genetic result guides clinical management. We used next‐generation sequencing to identify a homozygous pathogenic variant, p.(Arg244*)
Russell Donis +5 more
wiley +1 more source
The Antioxidant Status and Concentrations of Coenzyme Q10 and Vitamin E in Metabolic Syndrome
The Scientific World Journal, 2013 The purpose of this study was to investigate the levels of coenzyme Q10 and vitamin E and the antioxidant status in subjects with metabolic syndrome (MS). Subjects with MS (n=72) were included according to the criteria for MS.
Chi-Hua Yen +5 more
doaj +1 more source