Heavy Metals Toxicity: Mechanism, Health Effects, and Therapeutic Interventions
MedComm, Volume 6, Issue 9, September 2025.Heavy metals exert a wide range of effects at the cellular, molecular, and genetic levels, leading to neurological damage, renal dysfunction, cardiovascular disease, reproductive developmental abnormality, immune system abnormality, and increased risk of cancer by interfering with biomolecule function, signaling pathways, inducing oxidative stress, and
Yu‐feng Cheng +3 more
wiley +1 more source
Evaluation of cytogenetic and DNA damage in mitochondrial disease patients: effects of coenzyme Q10 therapy [PDF]
, 2003 Lucia Migliore
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Mitochondrial Dysfunction in Neurodegenerative Diseases
MedComm, Volume 6, Issue 9, September 2025.Overview of mitochondrial dysfunction in neurodegenerative diseases (NDDs). Mitochondrial dysfunction in NDDs involves impaired ATP synthesis, Ca2+ imbalance, oxidative stress, and apoptosis. Assessment methods integrate functional assays, omics, and imaging.
Chongyang Chen +10 more
wiley +1 more source
Angewandte Chemie, Volume 137, Issue 35, August 25, 2025.We have developed a macrocyclic tetranuclear palladium complex, which has four coordination sites within its inner cavity as a host molecule. The complex captured squalene (C30H50), a linear triterpene with six C═C double bonds, through multipoint palladium‐carbon bonds, and formed a unique host‐guest complex with a folded‐squalene structure.
Kohtaro Sugawara +2 more
wiley +2 more sources
Preparation and characterization of novel coenzyme Q10 nanoparticles engineered from microemulsion precursors [PDF]
, 2003 Cheng-Hsuan Hsu +3 more
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Programmed Cell Death in Cancer
MedComm, Volume 6, Issue 9, September 2025.Cancer is one of the most common and lethal diseases globally, with programmed cell death (PCD) playing a pivotal role in its pathogenesis and treatment. This comprehensive review covers the origin, developmental trajectory, and mechanisms of various PCDs, as well as their molecular connections with cancers. Latest studies have increasingly highlighted
Yuang Wei +3 more
wiley +1 more source
Cosupplementation with vitamin E and coenzyme Q10 reduces circulating markers of inflammation in baboons [PDF]
, 2004 Xing Li Wang +3 more
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Mitochondrial Dysfunction in Aging: Future Therapies and Precision Medicine Approaches
MedComm – Future Medicine, Volume 4, Issue 3, September 2025.Mitochondria play a critical role in aging and aging‐related diseases. This review systematically explores the mechanisms underlying mitochondrial deterioration during aging and highlights innovative therapeutic strategies for these mitochondrial problems.
Lanlan Jia +4 more
wiley +1 more source
Primary Progressive Multiple Sclerosis: New Therapeutic Approaches
Neuropsychopharmacology Reports, Volume 45, Issue 3, September 2025.Primary progressive MS affects 10%–15% of MS patients, causing irreversible neurological impairment. Drugs like ocrelizumab show promise, while high‐dose biotin, simvastatin, and coenzyme Q10 are under investigation. Gene therapy and stem cell treatments also show potential.
Morteza Rajabi +8 more
wiley +1 more source
Vitamin E or coenzyme Q10 administration is not fully advantageous for heart mitochondrial function in diabetic goto kakizaki rats [PDF]
, 2004 Paulo J. Oliveira +8 more
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