Results 81 to 90 of about 96,183 (271)

In silico analysis of Coenzyme Q10 interaction with the heme-hemoglobin complex: Implications for oxidative stress and inflammation in severe malaria

Advances in Biomarker Sciences and Technology
Background: Plasmodium falciparum, the primary causative agent of severe malaria, catabolizes hemoglobin to obtain nutrients, resulting in the accumulation of toxic free heme.
David B. Ouko, Fredrick M. Musila, Peris W. Amwayi, Victoria K. Mwaeni, Dickson B. Kinyanyi, Grace W. Gitau, Alfred Orina Isaac, James Nyabuga Nyariki   +7 more
doaj   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

Protective role of coenzyme Q10 and vitamin e in cadmium induced oxidative Stress in the blood of rats [PDF]

, 2000
Cadmium (Cd) is a heavy metal commonly used in ecotoxicological studies. Cd induces oxidative damage in erythrocytes, causes loss of membrane function by enhancing lipid peroxidation and by alteration of the antioxidant defense system in ...
Maletić, Snežana, Žikić, Radoslav V., Štajn, Andraš Š., Ognjanović, Branka, Saičić, Zorica, Petrović, Vojislav M., Pavlović, Slađan   +6 more
core  

Cholestasis: The Close Relationship between Bile Acids and Coenzyme Q10 [PDF]

, 2019
Cholestasis is defined as the impairment in formation or excretion of bile from the liver to the intestine. It may result from defects in intrahepatic production of bile, impairment of hepatic transmembrane transporters, or mechanical obstruction to bile
Martinefski, Manuela Romina, Valeria P. Tripodi, Lucangioli, Silvia Edith, Bianciotti, Liliana Graciela, Liliana G. Bianciotti, Silvia E. Lucangioli, Tripodi, Valeria Paula, Manuela R. Martinefski   +7 more
core   +1 more source

The Effects of Coenzyme Q10 (CoQ10) on Ionizing Radiation- Induced Pancreatic β-Cell Injury

Endocrinology Research and Practice, 2023
Objective: This study investigated the antioxidant effect of coenzyme Q10 on ionizing radiation- induced oxidative damage in pancreatic β-cells. Methods: Twenty-four male rats were assigned to 4 groups.
Filiz Mercantepe, Levent Tümkaya, Tolga Mercantepe, Sema Yılmaz Rakıcı   +3 more
doaj  

Disorders of Human Coenzyme Q10 Metabolism: An Overview

International Journal of Molecular Sciences, 2020
Coenzyme Q10 (CoQ10) has a number of vital functions in all cells, both mitochondrial and extramitochondrial. In addition to its key role in mitochondrial oxidative phosphorylation, CoQ10 serves as a lipid soluble antioxidant, plays an important role in ...
I. Hargreaves, R. Heaton, D. Mantle
semanticscholar   +1 more source

Response of an Infant With Presumed Multiple Acyl‐CoA Dehydrogenase Deficiency (MADD) to Ketone Supplementation

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Multiple Acyl‐CoA Dehydrogenase Deficiency (MADD) is an autosomal recessive inborn error of metabolism caused by biallelic pathogenic variants in one of three known genes: ETFA, ETFB, and ETFDH. It can cause multisystem dysfunction, including cardiomyopathy in severe cases.
Yutaka Furuta, Kaitlyn N. Bloom, Jerry Vockley, Angela R. Grochowsky, Neena S. Agrawal, Ellen W. Strickler, Natalie N. Owen, Erica T. Gray, B. Lakshitha A. Perera, Eric R. Gamazon, Lynette C. Rives, Hua‐Chang Chen, Qi Liu, Rizwan Hamid, Joy D. Cogan, John A. Phillips III, Thomas A. Cassini, Bryce A. Schuler   +17 more
wiley   +1 more source

The protective role of coenzyme Q10 and vitamin E on antioxidant defense system in the heart of cadmium treated rats [PDF]

, 2002
Cadmium (Cd) is an important pollutant of environment which accwnulates in the liver and the kidneys, as well as in other tissues. Cd induces oxidative damage causing many metabolic, histological and pathological changes, such as nephrotoxicity ...
Maletić, Snežana, Žikić, Radoslav V., Štajn, Andraš Š., Ognjanović, Branka, Saičić, Zorica, Petrović, Vojislav M., Radojičić, Ratko, Pavlović, Slađan   +7 more
core  

The influence of coenzyme Q10 supplementation on antioxidant defense system in the liver of cadmium treated Rats [PDF]

, 2000
Coenzyme Q10 in its reduced form (CoQ10Hz) is a powerful antioxidant. As an ant io x idant it is exploited either directly upon superoxide or indirectly on lipid radic als.
Štajn, Andraš Š., Žikić, Radoslav V., Ognjanović, Branka, Saičić, Zorica, Petrović, Vojislav M., Pavlović, Slađan   +5 more
core  

The Relationship between Coenzyme Q10, Oxidative Stress, and Antioxidant Enzymes Activities and Coronary Artery Disease

The Scientific World Journal, 2012
A higher oxidative stress may contribute to the pathogenesis of coronary artery disease (CAD). The purpose of this study was to investigate the relationship between coenzyme Q10 concentration and lipid peroxidation, antioxidant enzymes activities and the
Bor-Jen Lee, Yi-Chin Lin, Yi-Chia Huang, Ya-Wen Ko, Simon Hsia, Ping-Ting Lin   +5 more
doaj   +1 more source