Thermodynamic characterization of substrate and inhibitor binding to Trypanosoma brucei 6-phosphogluconate dehydrogenase [PDF]
, 2007 6-Phosphogluconate dehydrogenase is a potential target for new drugs against African trypanosomiasis. Phosphorylated aldonic acids are strong inhibitors of 6-phosphogluconate dehydrogenase, and 4-phospho-d-erythronate (4PE) and 4-phospho-d ...
Cervellati, Carlo +3 more
core +2 more sources
Determination of a method for extraction of coenzyme Q10 in human plasma: optimization of the use of surfactants and other variables [PDF]
Einstein (São Paulo), 2012 Objective: To establish a routine for the extraction of the total levelsof CoQ10 in human plasma through the Ultra High Performance LiquidChromatography (UHPLC). Methods: Two extraction protocolswere tested: a) methanol: hexane and b) 1-propanol.
Claudia Cristina Ferreiro-Barros +2 more
doaj +2 more sources
Experimental preeclampsia development depends on vitamin D(3) status in female wistar rats [PDF]
The Ukrainian Biochemical JournalDeficiency of vitamin D3 during pregnancy is a widespread challenge associated with increased risk of complications, particularly preeclampsia (PE), a serious condition characterized by hypertension with proteinuria.
I. V. Poladych +3 more
doaj +1 more source
Ultrafast absorption kinetics of NADH in folded and unfolded conformations [PDF]
, 2013 The non-radiative energy transfer is shown to occur on a ~3ps time scale for NADH in the folded form in H2O.
Groma, G. I. +4 more
core +1 more source
Coenzyme A thiosulfonate (coenzyme A disulfide-S,S-dioxide), an affinity analog of coenzyme A.
Journal of Biological Chemistry, 1982 The structure of the CoA affinity analog-oxidized CoA disulfide (o-CoAS2) (Collier, G. E., and Nishimura, J. S. (1978) J. Biol. Chem. 253, 4938-4939) has been deduced to be that of the thiosulfonate of CoA, i.e. coenzyme A disulfide-S,S-dioxide. This deduction is based on several considerations among which are: the cleavage of o-CoAS2 by dithiothreitol
J S, Nishimura +3 more
openaire +2 more sources
B Vitamins and Their Roles in Gut Health
Microorganisms, 2022 B vitamins act as coenzymes in a myriad of cellular reactions. These include energy production, methyl donor generation, neurotransmitter synthesis, and immune functions.
Khandkar Shaharina Hossain +2 more
doaj +1 more source
Effect of metabolic and antioxidant supplementation on sperm parameters in oligo-astheno-teratozoospermia, with and without varicocele: a double-blind placebo-controlled study [PDF]
, 2018 Since sperm require high energy levels to perform their specialised function, it is vital that essential nutrients are available for spermatozoa when they develop, capacitate and acquire motility.
Agarwal, A. +8 more
core +1 more source
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Effect of nitrous oxide on folate coenzyme distribution and de novo synthesis of thymidylate in human bone marrow cells [PDF]
, 1992 The effect of nitrous oxide on intracellular folate metabolism of the human bone marrow was studied in vitro. Bone marrow cells, obtained from healthy volunteers, were incubated with 5 × 10−8m-[3H]5-formyltetrahydrofolate (5-formylTHF) for 18 hr to label
Abels, J. (Lyanne) +3 more
core +1 more source
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source