Results 61 to 70 of about 86,596 (332)

Peningkatan akumulasi tiamin pada kultur Escherichia coli melalui peningkatan oksigenasi dan penghilangan rpoS

Agrointek
Microorganisms as cell factories in producing a product are strongly influenced by their metabolism. engineering microbial metabolism by increasing coenzymes that play a role in enzyme activity.
Nuraliah Rusman, Prayoga Suryadarma, Nisa Rachmania Mubarik   +2 more
doaj   +1 more source

Polyglutamylation of Folate Coenzymes Is Necessary for Methionine Biosynthesis and Maintenance of Intact Mitochondrial Genome inSaccharomyces cerevisiae *

Journal of Biological Chemistry, 2000
One-carbon metabolism is essential to provide activated one-carbon units in the biosynthesis of methionine, purines, and thymidylate. The major forms of folates in vivo are polyglutamylated derivatives.
H. Cherest, Dominique Thomas, Y. Surdin-Kerjan   +2 more
semanticscholar   +1 more source

Lactylation of HMGB1 at K177 Drives Nuclear Export of TIAR to Promote Hypoxia‐Induced Stress Granule Formation

Advanced Science, EarlyView.
This study uncovers a novel mechanism in which p300‑catalyzed lactylation of HMGB1 triggers nuclear export of the HMGB1‐TIAR complex, driving TIAR‐dependent SGs formation in the cytoplasm. Mass spectrometry and mutagenesis reveals that K177 lactylation is essential for this export and subsequent SGs formation.
Chengyu Li, Zhaojun Liu, Linjie Zhu, Gang Wu, Chen Fu, Hongmin Li, Tong He, Ming Shen, Honglin Liu   +8 more
wiley   +1 more source

BOFdat: Generating biomass objective functions for genome-scale metabolic models from experimental data.

PLoS Computational Biology, 2019
Genome-scale metabolic models (GEMs) are mathematically structured knowledge bases of metabolism that provide phenotypic predictions from genomic information.
Jean-Christophe Lachance, Colton J Lloyd, Jonathan M Monk, Laurence Yang, Anand V Sastry, Yara Seif, Bernhard O Palsson, Sébastien Rodrigue, Adam M Feist, Zachary A King, Pierre-Étienne Jacques   +10 more
doaj   +1 more source

The RNA World: Piecing together the historical development of a hypothesis

Mètode Science Studies Journal: Annual Review, 2016
The concept of an RNA world is a hypothesis firmly rooted in empirical data and is part of a long and complex scientific perspective that goes back more than fifty years to the discovery of the central role RNA and ribonucleotides play in protein ...
Antonio Lazcano
doaj   +1 more source

Decoding Dental Stem Cell Aging: Mechanisms, Therapeutic Strategies, and Beyond

Advanced Science, EarlyView.
Dental stem cell (DSC) aging involves genomic instability, mitochondrial dysfunction, telomere attrition, and epigenetic alterations, leading to impaired proliferation, reduced differentiation potential, and pro‐inflammatory secretory activity. These processes drive cellular senescence and compromise regenerative and immunomodulatory functions, thereby
Xinyuan Zhao, Yunfan Lin, Pei Lin, Ye Lu, Jiarong Zheng, Xu Chen, Zihao Zhou, Li Cui   +7 more
wiley   +1 more source

EETs Reduction Contributes to Granulosa Cell Senescence and Endometriosis‐Associated Infertility via the PI3K/AKT/mTOR Signaling Pathway

Advanced Science, EarlyView.
1) 14, 15‐EET levels were decreased in ovarian granulosa cells, follicular fluid, peritoneal fluid from endometriosis patients. 2) EETs reduction in endometriosis follicular fluid aggravated granulosa cell senescence. 3) ROS reduced 14, 15‐EET levels by upregulating EPHX2 through a mechanism involving histone methylation modification.
Xiang Lin, Weijia Gu, Xiaomei Tong, Mengru Lai, Yi Zhang, Na Liu, Xiaoying Jin, Chao Li, Dong Huang, Feng Zhou, Yongdong Dai, Songying Zhang   +11 more
wiley   +1 more source

Folic Acid Effect on Arginase Activity in Human Colostrum and Mature Milk

Pteridines, 2012
Folic acid, or folates are available from a large variety of sources, such as green leafy vegetables (spinach, beans) and liver. The importance of folates is based on their requirement as coenzymes in the transfer and utilization of one-carbon units in a
Bjelakovic Ljiljana, Kocic Gordana, Stojanovic Ivana, Jevtovic-Stoimenov Tatjana, Najman Stevo, Sokolovic Dusan, Stojanovic Svetlana, Kocic Gordana   +7 more
doaj   +1 more source

Design, Synthesis and SAR Studies of NAD Analogues as Potent Inhibitors towards CD38 NADase

Molecules, 2014
Nicotinamide adenine dinucleotide (NAD), one of the most important coenzymes in the cells, is a substrate of the signaling enzyme CD38, by which NAD is converted to a second messenger, cyclic ADP-ribose, which releases calcium from intracellular calcium ...
Shengjun Wang, Wenjie Zhu, Xuan Wang, Jianguo Li, Kehui Zhang, Liangren Zhang, Yong-Juan Zhao, Hon Cheung Lee, Lihe Zhang   +8 more
doaj   +1 more source

Production of Vitamin B2 (Riboflavin) by Microorganisms: An Overview

Frontiers in Bioengineering and Biotechnology, 2020
Riboflavin is a crucial micronutrient that is a precursor to coenzymes flavin mononucleotide and flavin adenine dinucleotide, and it is required for biochemical reactions in all living cells.
Liudmila A. Averianova, Larissa A. Balabanova, Larissa A. Balabanova, Oksana M. Son, Oksana M. Son, Anna B. Podvolotskaya, Anna B. Podvolotskaya, Liudmila A. Tekutyeva, Liudmila A. Tekutyeva   +8 more
doaj   +1 more source