Results 121 to 130 of about 1,272 (143)

Grounded situation recognition under data scarcity. [PDF]

Sci Rep
Zhou J, Liu Z, Hu S, Li X, Wang Z, Lu Q.
europepmc   +1 more source

Using the Cocrystal Approach as a Promising Drug Delivery System to Enhance the Dissolution and Bioavailability of Formononetin Using an Imidazole Coformer. [PDF]

Pharmaceuticals (Basel)
Kim J, Lim S, Kim M, Ban E, Kim Y, Kim A.   +5 more
europepmc   +1 more source

Cocrystals by Design: A Rational Coformer Selection Approach for Tackling the API Problems

Pharmaceutics, 2023
Active pharmaceutical ingredients (API) with unfavorable physicochemical properties and stability present a significant challenge during their processing into final dosage forms.
Maan Singh, Harsh Barua, Madhukiran R Dhondale   +2 more
exaly   +5 more sources

Critical Analysis and Optimization of Stoichiometric Ratio of Drug-Coformer on Cocrystal Design: Molecular Docking, In Vitro and In Vivo Assessment

Pharmaceuticals, 2023
In this present research, an attempt has been made to address the influence of drug-coformer stoichiometric ratio on cocrystal design and its impact on improvement of solubility and dissolution, as well as bioavailability of poorly soluble telmisartan ...
Manami Dhibar, Santanu Chakraborty, Souvik Basak   +2 more
exaly   +4 more sources

The effects of pH, surfactant, ion concentration, coformer, and molecular arrangement on the solubility behavior of myricetin cocrystals

Acta Pharmaceutica Sinica B, 2019
Pharmaceutical cocrystals are a promising technology that can be used to improve the solubility of poor aqueous compounds. The objective of this study was to systematically investigate the solubility of myricetin (MYR) cocrystals, including their kinetic
Chao Hong, Guowen Li, Yan Xie
exaly   +4 more sources

Influence of Coformer Stoichiometric Ratio on Pharmaceutical Cocrystal Dissolution: Three Cocrystals of Carbamazepine/4-Aminobenzoic Acid

Molecular Pharmaceutics, 2016
Cocrystallization is a technique to optimize solid forms that shows great potential to improve the solubility of active pharmaceutical ingredients (APIs).
Zi Li, Adam J Matzger
exaly   +2 more sources

In Situ Monitoring of Competitive Coformer Exchange Reaction by 1H MAS Solid-State NMR

Molecular Pharmaceutics
YesIn a competitive coformer exchange reaction, a recent topic of interest in pharmaceutical research, the coformer in a pharmaceutical cocrystal is exchanged with another coformer which is expected to form a cocrystal that is more stable.
Anant Paradkar, T G Ajithkumar
exaly   +2 more sources

Effects of Coformer and Polymer on Particle Surface Solution-Mediated Phase Transformation of Cocrystals in Aqueous Media

Molecular Pharmaceutics, 2020
The purpose of the present study was to investigate the effect of the coformer difference on particle surface solution-mediated phase transformation (PS-SMPT) during cocrystal particle dissolution in aqueous media in the absence and presence of polymers.
Maaya Omori, Daisuke Inoue, Kiyohiko Sugano   +2 more
exaly   +2 more sources