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Among the coformers and cocrystals
2023Cocrystals have emerged as an exciting avenue for altering the behavior of drugs and creating new patents or intellectual properties in the pharmaceutical industry. However, the preparation of pharmaceutical cocrystals remains relatively uncommon, presenting a potential field for innovation. The advantage of cocrystals lies in their ability to preserve
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Temozolomide Cocrystals with Carboxamide Coformers
Crystal Growth & Design, 2013Temozolomide (TMZ) is an antitumor prodrug of broad spectrum antineoplastic activity. TMZ is stable in acidic medium (pH 7). In continuation of our efforts to design stable cocrystals of TMZ with partners such as organic acids (pKa 2–5) and a salt dihydrate with hydrochloric acid, we report herein TMZ cocrystals with amide coformers, e.g ...
Palash Sanphui +2 more
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A new polymorph of the common coformer isonicotinamide
CrystEngComm, 2019A polymorph of the widely employed coformer isonicotinamide crystallizing in the space group Pca21 is described for the first time.
Alexios I. Vicatos, Mino R. Caira
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CrystEngComm, 2013
Four original cocrystal structures incorporating a zwitterionic amino acid, prolinium, and a therapeutical agent from profen pharmaceutical family, naproxen, are highlighted and characterized in this study. Powder X-ray diffraction and differential scanning calorimetry permits the observation of the formation of the new structures, obtained by liquid ...
Tilborg, A. +4 more
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Four original cocrystal structures incorporating a zwitterionic amino acid, prolinium, and a therapeutical agent from profen pharmaceutical family, naproxen, are highlighted and characterized in this study. Powder X-ray diffraction and differential scanning calorimetry permits the observation of the formation of the new structures, obtained by liquid ...
Tilborg, A. +4 more
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Dissolution Profiles of Carbamazepine Cocrystals with Cis–Trans Isomeric Coformers
Pharmaceutical Research, 2022The purpose of the present study was to investigate the dissolution profiles of cocrystals with cis-trans isomeric coformers. Previously, the carbamazepine (CBZ) cocrystals with even-carbon dicarboxylic acids showed higher supersaturation than those with odd-carbon ones, attributed to particle surface solution-mediated phase transformation (PS-SMPT) to
Maaya Omori +3 more
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Multicomponent solids of diclofenac with pyridine based coformers
Journal of Molecular Structure, 2020Abstract The present study reports nine crystalline forms of diclofenac acid which include cocrystals, salts, salt-cocrystals and salt hydrates with pyridines and amines based coformers utilizing acid … pyridine synthon. All the solids were successfully prepared and structurally characterized through PXRD, ATR, DSC and single crystal XRD. The crystal
Pramod Kumar Goswami +2 more
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Exploring potential coformers for oxyresveratrol using principal component analysis
International Journal of Pharmaceutics, 2020Oxyresveratrol (OXY) exhibits poor bioavailability due to its low solubility. Cocrystals are effective in improving solubility of OXY. In this study, principal component analysis (PCA) was employed for coformer selection using 5 variables (solubility parameter, logP, hydrogen bonding acceptor, hydrogen bonding donor and molecular volume).
Passaporn Ouiyangkul +2 more
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On the coformality of classifying spaces for fibrewise self-equivalences
Homology, Homotopy and ApplicationszbMATH Open Web Interface contents unavailable due to conflicting licenses.
Nishinobu, Hirokazu +1 more
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Mechanochemical Transformations of Pharmaceutical Cocrystals: Polymorphs and Coformer Exchange
Chemistry – A European JournalAbstractTransformations of solid samples under solvent‐free or minimal solvent conditions set the future trend and define a modern strategy for the production of new materials. Of the various technologies tested in recent years, the mechanochemical approach seems to be the most promising for economic and ecological reasons.
Katarzyna Trzeciak +2 more
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