Mechanochemical Synthesis of Pharmaceutical Cocrystal Suspensions via Hot Melt Extrusion: Feasibility Studies and Physicochemical Characterisation [PDF]
, 2016 Engineered cocrystals offer an alternative solid drug form with tailored physicochemical properties. Interestingly, although cocrystals provide many new possibilities, they also present new challenges, particularly in regard to their design and large ...
Andrews, Gavin P. +5 more
core +1 more source
SYSTEMATIC REVIEW: COCRYSTAL AS EFFORTS TO IMPROVE PHYSICOCHEMICAL AND BIOAVAILABILITY PROPERTIES OF ORAL SOLID DOSAGE FORM [PDF]
, 2021 Water solubility and low bioavailability of active pharmaceutical ingredients are some of the main challenges in the process of developing new drugs, especially drugs in oral solid dosage forms.
B., ALVIN +4 more
core +3 more sources
Synthesis, characterization, and stability study of desloratadine multicomponent crystal formation
Research in Pharmaceutical Sciences, 2018 This study describes the formation of multicomponent crystal (MCC) of desloratadine (DES). The objective of this study was to discover the new pharmaceutical MCC of DES using several coformers. The MCC synthesis was performed between DES and 26 coformers
Ahmad Ainurofiq +3 more
doaj +1 more source
Recent advances in improving oral drug bioavailability by cocrystals [PDF]
BioImpacts, 2018 Introduction: Oral drug delivery is the most favored route of drug administration. However, poor oral bioavailability is one of the leading reasons for insufficient clinical efficacy.
Shahram Emami +3 more
doaj +1 more source
Multicomponent Solids of Niflumic and Mefenamic Acids Based on Acid-Pyridine Synthon
Frontiers in Chemistry, 2022 The present study discusses comparative structural features of fourteen multicomponent solids of two non-steroidal anti-inflammatory drugs, Niflumic and Mefenamic acids, with amine and pyridine-based coformers.
Vineet Kumar +5 more
doaj +1 more source
Propellants, Explosives, Pyrotechnics, EarlyView.Ammonium dinitramide (ADN) and 3,4‐Diaminofurazan (DAF) form a 1:1 energetic cocrystal. We report its crystal structure and spectroscopic signature and evaluate thermal stability, decomposition behavior, hygroscopicity, and combustion properties. Propellant performance calculations benchmark the material against guanylurea dinitramide (GuDN) and ...
Peter Schultz +2 more
wiley +1 more source
Salt and ionic cocrystalline forms of amides: protonation of carbamazepine in aqueous media [PDF]
, 2015 The products of reactions of the pharmaceutical amide carbamazepine (CBZ) with strong acids under aqueous conditions were investigated by both powder and single crystal X-ray diffraction.
Alan R. Kennedy +9 more
core +3 more sources
Charge Transport in Ternary Charge‐Transfer Solid Solution Single Crystals
Advanced Functional Materials, Volume 36, Issue 26, 30 March 2026.This study deconvolutes the roles of indirect (superexchange) and direct electronic coupling on charge transport in single crystals of an organic charge‐transfer molecular semiconductor (OSC). This model system elegantly demonstrates that structural defects introduced by chemical dopants play a significant role in the electronic performance ...
Jonathan C. Novak +7 more
wiley +1 more source
Supramolecular hair dyes : a new application of cocrystallization [PDF]
, 2016 The manuscript presents the first report of hair dyes of various colors formed by the cocrystallization reactions. Unlike the most popular oxidative hair dye (OHD) products, these dyes are NH3 free and do not require H2O2 as a color developer.
Delori, Amit +2 more
core +1 more source
Exploring the cocrystal landscape of posaconazole by combining high-throughput screening experimentation with computational chemistry [PDF]
, 2022 The development of multicomponent crystal forms, such as cocrystals, represents a means to enhance the dissolution and absorption properties of poorly water-soluble drug compounds.
Bauer-Brandl, Annette +4 more
core +1 more source