Results 41 to 50 of about 666,445 (211)

Using Online Lectures to Promote Engagement: Recognising the Self-Directed Learner as Critical for Practical Inquiry

Journal of Open, Flexible and Distance Learning, 2020
This study analyzed the relationships between teaching presence, social presence and cognitive presence in online learning environments (Garrison, Anderson, & Archer, 2000), with an emphasis on examining ways in which the design of instructor ...
Robin Henrikson
doaj   +2 more sources

Enhancing nursing students' cultural awareness through Community of Inquiry‐guided online ‘Internationalization at Home’ strategies—An intervention study

Nursing Open
Aim Internationalization at Home (IaH) strategies play an important role in nursing curricula to enhance nursing students' cultural awareness in the globalized world.
Siu Ling Chan, John Tai Chun Fung, Naomi Takemura, Pui Hing Chau, Jay Jung Jae Lee, Hye Ri Choi, Wai Hin Wan, Harrison Withrow, Chia‐Chin Lin   +8 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

The Predictive Role of Community of Inquiry in Shaping Students' Creative Self‐Concept: A Cross‐Sectional Study

Nursing Open
Background Creative self‐concept is essential for nursing students as it supports innovation, adaptability and problem‐solving in clinical practice. The community of inquiry framework offers a model for promoting reflective and meaningful learning.
Shaherah Yousef Andargeery, Norah Mohammed Alotaibi, Ghalia Mohammed Almadi, Layan Ali Alhazmi, Lama Fahad Alwehaibi, Razan Faisal Alkathiri, Sadeem Saleh Albalawi, Hatoon Hashan Alqahtani, Rana Mohammed Alsubaie, Murad H. Taani, Salwa Mohammad Maghrabi   +10 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Moderating effects of student heterogeneity on community of inquiry affective outcomes: A multigroup analysis

Computers and Education Open
This study examines the influence of student background attributes on the relationships between Community of Inquiry (CoI) presences and affective learning outcomes in online courses. Using partial least squares structural equation modeling (PLS-SEM) and
Teng Seng Choo, Hazri Jamil, Lei Mee Thien   +2 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source