Communication between distinct subunit interfaces of the cohesin complex promotes its topological entrapment of DNA [PDF]
eLife, 2019 Cohesin mediates higher order chromosome structure. Its biological activities require topological entrapment of DNA within a lumen(s) formed by cohesin subunits.
Vincent Guacci +3 more
doaj +4 more sources
Cohesin reconstitution and homologous recombination repair of DNA double-strand breaks in late mitosis [PDF]
eLifeThe cohesin complex maintains sister chromatid cohesion from S phase to anaphase onset. Cohesin also plays roles in chromosome structure and DNA repair.
Jessel Ayra Plasencia +5 more
doaj +2 more sources
Heterochromatin protein 1 (HP1) proteins do not drive pericentromeric cohesin enrichment in human cells. [PDF]
PLoS ONE, 2009 Sister chromatid cohesion mediated by cohesin is essential for accurate chromosome segregation. Classical studies suggest that heterochromatin promotes cohesion, but whether this happens through regulation of cohesin remains to be determined ...
Angel Serrano +2 more
doaj +3 more sources
Cohesin residency determines chromatin loop patterns
eLife, 2020 The organization of chromatin into higher order structures is essential for chromosome segregation, the repair of DNA-damage, and the regulation of gene expression.
Lorenzo Costantino +4 more
doaj +2 more sources
Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus.
PLoS Genetics, 2009 Cohesin is a chromatin-associated protein complex that mediates sister chromatid cohesion by connecting replicated DNA molecules. Cohesin also has important roles in gene regulation, but the mechanistic basis of this function is poorly understood.
Raffaella Nativio +9 more
doaj +3 more sources
Cohesin-independent STAG proteins interact with RNA and R-loops and promote complex loading
eLife, 2023 Most studies of cohesin function consider the Stromalin Antigen (STAG/SA) proteins as core complex members given their ubiquitous interaction with the cohesin ring.
Hayley Porter +12 more
doaj +3 more sources
A genetic screen for modifiers of cohesin clustering identifies regulators of genome folding. [PDF]
Sci AdvKim W +5 more
europepmc +2 more sources
Cohesin architecture and clustering in vivo
eLife, 2021 Cohesin helps mediate sister chromatid cohesion, chromosome condensation, DNA repair, and transcription regulation. We exploited proximity-dependent labeling to define the in vivo interactions of cohesin domains with DNA or with other cohesin domains ...
Siheng Xiang, Douglas Koshland
doaj +1 more source
Genome-wide control of RNA polymerase II activity by cohesin. [PDF]
PLoS Genetics, 2013 Cohesin is a well-known mediator of sister chromatid cohesion, but it also influences gene expression and development. These non-canonical roles of cohesin are not well understood, but are vital: gene expression and development are altered by modest ...
Cheri A Schaaf +8 more
doaj +1 more source
A conserved domain in the scc3 subunit of cohesin mediates the interaction with both mcd1 and the cohesin loader complex. [PDF]
PLoS Genetics, 2015 The Structural Maintenance of Chromosome (SMC) complex, termed cohesin, is essential for sister chromatid cohesion. Cohesin is also important for chromosome condensation, DNA repair, and gene expression. Cohesin is comprised of Scc3, Mcd1, Smc1, and Smc3.
Ola Orgil +5 more
doaj +1 more source