Recent advances in cohesin biology [PDF]
F1000Research, 2016 Sister chromatids are tethered together from the time they are formed in S-phase until they separate at anaphase. A protein complex called cohesin is responsible for holding the sister chromatids together and serves important roles in chromosome condensation, gene regulation, and the repair of DNA damage.
Rankin, Susannah, Dawson, Dean S.
openaire +2 more sources
Epigenetics & ChromatinBackground Cohesin is a major regulator of three-dimensional genome organization and gene expression. Cohesin associates with DNA and dynamically extrudes a DNA loop, often bringing two cis-regulatory elements physically close together. Extruding cohesin
Audra F. Bryan +4 more
doaj +1 more source
Cohesin protects genes against γH2AX Induced by DNA double-strand breaks. [PDF]
PLoS Genetics, 2012 Chromatin undergoes major remodeling around DNA double-strand breaks (DSB) to promote repair and DNA damage response (DDR) activation. We recently reported a high-resolution map of γH2AX around multiple breaks on the human genome, using a new cell-based ...
Pierre Caron +8 more
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The Interplay of Cohesin and the Replisome at Processive and Stressed DNA Replication Forks [PDF]
, 2021 Janne J. M. van Schie, Job de Lange
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Rad62 protein functionally and physically associates with the Smc5/Smc6 protein complex and is required for chromosome integrity and recombination repair in fission yeast [PDF]
, 2004 Smc5 and Smc6 proteins form a heterodimeric SMC (structural maintenance of chromosome) protein complex like SMC1-SMC3 cohesin and SMC2-SMC4 condensin, and they associate with non-SMC proteins Nse1 and Nse2 stably and Rad60 transiently.
Carr, Antony +5 more
core +2 more sources
SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis
Cell Proliferation, EarlyView.The transcription factor SOX30 directly binds promoter regions of SYCE1 and SYCE2 to mediate their transcriptional activation, thereby enabling proper assembly of central elements within the synaptonemal complex. Structural destabilisation of the synaptonemal complex in Sox30 KK spermatocytes triggers synaptic discontinuity, impairs homologous ...
Kangle Liu +16 more
wiley +1 more source
BiFCo: visualizing cohesin assembly/disassembly cycle in living cells [PDF]
, 2023 Emilio González-Martín +2 more
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CTCF-mediated transcriptional regulation through cell type-specific chromosome organization in the {\beta}-globin locus [PDF]
, 2012 The principles underlying the architectural landscape of chromatin beyond the nucleosome level in living cells remains largely unknown despite its potential to play a role in mammalian gene regulation. We investigated the 3-dimensional folding of a 1 Mbp
Ann Dean +56 more
core +6 more sources
Transcriptional regulation of human NMNAT2: insights from 3D genome sequencing and bioinformatics
The FEBS Journal, EarlyView.NMNAT2 is a valuable drug target, as low levels increase the risk of neurodegeneration. We employed 4C‐seq to identify NMNAT2 regulatory regions in the human genome, revealing distinct interactomes of the NMNAT2 promoter in undifferentiated and neuron‐like SH‐SY5Y cells. Additionally, we uncovered NMNAT2‐associated genes and transcription factors. This
Yu Chen Chang +5 more
wiley +1 more source
Repression of transcription at DNA breaks requires cohesin throughout interphase and prevents genome instability [PDF]
, 2019 Cohesin subunits are frequently mutated in cancer, but how they function as tumor suppressors is unknown. Cohesin mediates sister chromatid cohesion, but this is not always perturbed in cancer cells.
Benstead-Hume, Graeme +7 more
core +2 more sources