Results 111 to 120 of about 31,924 (248)

Proteomic analysis of the zone of degeneration at the mitosis–meiosis transition stage in wild‐caught male catshark (Scyliorhinus canicula), correlated with an unusually high‐water temperature in the English Channel

Journal of Fish Biology, EarlyView.
Abstract In the context of current global change, variations in water temperature are one of the environmental conditions with serious consequences for marine life, including reproductive processes. In the small spotted catshark Scyliorhinus canicula, spermatogenesis occurs in spermatocysts composed of synchronously developing germ cells associated ...
Fabian Jeanne, Stanislas Pilet, Sean Heighton, Benoît Bernay, Pascal Sourdaine   +4 more
wiley   +1 more source

RAD21 is the core subunit of the cohesin complex involved in directing genome organization

Genome Biology, 2023
Background The ring-shaped cohesin complex is an important factor for the formation of chromatin loops and topologically associating domains (TADs) by loop extrusion.
Yuao Sun, Xin Xu, Wenxue Zhao, Yu Zhang, Keyang Chen, Yongzheng Li, Xiaotian Wang, Mengling Zhang, Boxin Xue, Wanting Yu, Yingping Hou, Chaobin Wang, Wei Xie, Cheng Li, Daochun Kong, Shu Wang, Yujie Sun   +16 more
doaj   +1 more source

Review of expansion microscopy combined with advanced imaging modalities

Journal of Microscopy, EarlyView.
Abstract Expansion microscopy (ExM) is a powerful high‐resolution imaging technique that enhances the spatial resolution of conventional light microscopy by physically enlarging biological specimens by embedding and cross‐linking them in a swellable polymer network.
Natalie Woo, Claire M. Brown
wiley   +1 more source

Cohesin Releases DNA through Asymmetric ATPase-Driven Ring Opening [PDF]

, 2016
Cohesin stably holds together the sister chromatids from S phase until mitosis. To do so, cohesin must be protected against its cellular antagonist Wapl. Eco1 acetylates cohesin's Smc3 subunit, which locks together the sister DNAs. We used yeast genetics
Celie, P.H. (Patrick H.), Chapard, C. (Christophe), Elbatsh, A.M.O. (Ahmed M.O.), Fish, A. (Alexander), Haarhuis, J.H.I. (Judith H.I.), Medema, R.H. (Rene), Nasmyth, K. (Kim), Petela, N. (Naomi), Ristic, D. (Dejan), Rowland, B.D. (Benjamin D.), Stadnik, M. (Magda), Wyman, C. (Claire)   +11 more
core   +2 more sources

A stage‐dependent seed defense response to explain efficient seed transmission of Xanthomonas citri pv. fuscans to common bean

Plant, Cell &Environment, EarlyView.
Abstract Although seed represents an important means of plant pathogen dispersion, the seed–pathogen dialogue remains largely unexplored. A multiomic approach was performed at different seed developmental stages of common bean (Phaseolus vulgaris L.) during asymptomatic colonization by Xanthomonas citri pv.
Armelle Darrasse, Łukasz Paweł Tarkowski, Martial Briand, David Lalanne, Nicolas W. G. Chen, Matthieu Barret, Jerome Verdier   +6 more
wiley   +1 more source

Interallelic complementation provides functional evidence for cohesin–cohesin interactions on DNA

Molecular Biology of the Cell, 2015
The cohesin complex (Mcd1p, Smc1p, Smc3p, and Scc3p) has multiple roles in chromosome architecture, such as promoting sister chromatid cohesion, chromosome condensation, DNA repair, and transcriptional regulation. The prevailing embrace model for sister chromatid cohesion posits that a single cohesin complex entraps both sister chromatids.
Eng, Thomas, Guacci, Vincent, Koshland, Douglas   +2 more
openaire   +4 more sources

Linking Cohesin to Gene Regulation [PDF]

Cell, 2008
During cell division the cohesin complex mediates the pairing of sister chromatids. Emerging evidence shows that cohesin also has roles in interphase cells. New studies, including that of Gullerova and Proudfoot (2008) in this issue, reveal how cohesin is targeted to specific sites on chromosomes and implicate cohesin in the regulation of gene ...
Peric-Hupkes, Daniel, van Steensel, Bas
openaire   +2 more sources

DNA repair: Disorders [PDF]

, 2010
No description ...
Bose, Burg, Caldecott, Chu, Digweed, Fernandez-Capetillo, Fousteri, Fousteri, Friedberg, Gudmundsdottir, Hashimoto, Hoeijmakers, Jiricny, Kraemer, Lavin, Lehmann, Lieber, Ma, Masutani, McCulloch, Meindl, Moldovan, Moshous, Nance, Nouspikel, O'Driscoll, O'Driscoll, O'Driscoll, O'Driscoll, Rass, Stefanini, Stewart, Stracker, Taylor, Vaz, Wu, Zlatanou   +36 more
core   +1 more source

Impact of Mutational Landscape and Burden on RBC Transfusion Response in Patients With Lower‐Risk Myelodysplastic Syndromes (LR‐MDS) in the COMMANDS Study

American Journal of Hematology, Volume 101, Issue 3, Page 427-438, March 2026.
ABSTRACT The COMMANDS trial established luspatercept as a first‐line treatment for anemia in transfusion‐dependent lower‐risk (LR) myelodysplastic syndromes (MDS). Here we report red blood cell (RBC) transfusion response analysis based on somatic mutations profile and disease risk for patients treated with luspatercept or epoetin alfa in the COMMANDS ...
Rami S. Komrokji, Sheida Hayati, Manuel Ugidos, Guillermo Garcia‐Manero, Matteo Giovanni Della Porta, Amer M. Zeidan, Valeria Santini, Uwe Platzbecker, Anita K. Gandhi, Rajasekhar N. V. S. Suragani   +9 more
wiley   +1 more source

The role of vitamin D receptor signaling in hair follicle health and alopecia: Current understanding and therapeutic implications

Journal of Cell Communication and Signaling, Volume 20, Issue 1, March 2026.
The vitamin D receptor (VDR) regulates hair follicle biology through ligand‐dependent and ligand‐independent mechanisms by heterodimerizing with retinoid X receptor, recruiting coactivator complexes, and activating target genes including Wnt inhibitors, hair keratins, and cell cycle regulators.
Liancheng Guan, Fan Yang, Meijuan Li, Yujia Chen, Zexin Zhao, Hongxia Li, Deping Luo, Qian Li, Yunzhi Chen   +8 more
wiley   +1 more source