Results 11 to 20 of about 31,924 (248)
Chromosomal localization of cohesin is differentially regulated by WIZ, WAPL, and G9a
BMC Genomics, 2022 Background The cohesin complex is essential for proper chromosome structure and gene expression. Defects in cohesin subunits and regulators cause changes in cohesin complex dynamics and thereby alter three-dimensional genome organization.
Megan Justice +4 more
doaj +1 more source
Cohesin causes replicative DNA damage by trapping DNA topological stress [PDF]
, 2020 DNA topological stress inhibits DNA replication fork (RF) progression and contributes to DNA replication stress. In Saccharomyces cerevisiae, we demonstrate that centromeric DNA and the rDNA array are especially vulnerable to DNA topological stress ...
Baxter, Jonathan +2 more
core +1 more source
Epigenetics & Chromatin, 2022 Background The cohesin complex organizes the genome-forming dynamic chromatin loops that impact on all DNA-mediated processes. There are two different cohesin complexes in vertebrate somatic cells, carrying the STAG1 or STAG2 subunit, and two versions of
Ana Cuadrado +6 more
doaj +1 more source
CTCF/cohesin-binding sites are susceptible to replication-associated DNA damage and genomic instability in cancer cells [PDF]
iScienceFaseela E, Notani D, Sabarinathan R.
europepmc +2 more sources
Intermediate step of cohesin’s ATPase cycle allows cohesin to entrap DNA [PDF]
Proceedings of the National Academy of Sciences, 2018 Significance Cohesin is an ATPase that organizes chromosome structure for chromosome segregation, gene expression, and DNA repair. Its function has been implicated in the prevention of cancer, birth defects, and several human disorders.
Gamze Çamdere +2 more
openalex +5 more sources
Different NIPBL requirements of cohesin-STAG1 and cohesin-STAG2
Nature Communications, 2022 AbstractCohesin organizes the genome through the formation of chromatin loops. NIPBL activates cohesin’s ATPase and is essential for loop extrusion, but its requirement for cohesin loading is currently unclear. Here we have examined the effect of reducing NIPBL levels on the behavior of the two cohesin variants carrying STAG1 or STAG2 by combining a ...
Dácil Alonso Gil +4 more
openaire +4 more sources
Separase prevents genomic instability by controlling replication fork speed [PDF]
, 2016 Proper chromosome segregation is crucial for preserving genomic integrity, and errors in this process cause chromosome mis-segregation, which may contribute to cancer development.
Cucco, Francesco +11 more
core +6 more sources
Pds5 promotes cohesin acetylation and stable cohesin–chromosome interaction [PDF]
EMBO reports, 2012 Pds5 and Wpl1 act as anti‐establishment factors preventing sister‐chromatid cohesion until counteracted in S‐phase by the cohesin acetyl‐transferase Eso1. However, Pds5 is also required to maintain sister‐chromatid cohesion in G2. Here, we show that Pds5 is essential for cohesin acetylation by Eso1 and ensures the maintenance of cohesion by promoting a
Vaur, Sabine +4 more
openaire +4 more sources
Cohesins and Cohesin-Regulators in Meiosis [PDF]
, 2012 Cells have rigorous mechanisms controlling sister chromatid cohesion during cell division to ensure proper distribution of genetic material to daughter cells. Errors in these mechanisms often lead to aneuploidy, frequently implicated in cell death, tumour development and infertility.
Calvente, Adela, Barbero, José L.
openaire +2 more sources
Genome-wide mapping of the cohesin complex in the yeast Saccharomyces cerevisiae. [PDF]
PLoS Biology, 2004 In eukaryotic cells, cohesin holds sister chromatids together until they separate into daughter cells during mitosis. We have used chromatin immunoprecipitation coupled with microarray analysis (ChIP chip) to produce a genome-wide description of cohesin ...
Earl F Glynn +7 more
doaj +1 more source