Results 21 to 30 of about 31,924 (248)

The CDK Pef1 and protein phosphatase 4 oppose each other for regulating cohesin binding to fission yeast chromosomes

eLife, 2020
Cohesin has essential roles in chromosome structure, segregation and repair. Cohesin binding to chromosomes is catalyzed by the cohesin loader, Mis4 in fission yeast. How cells fine tune cohesin deposition is largely unknown.
Adrien Birot, Marta Tormos-Pérez, Sabine Vaur, Amélie Feytout, Julien Jaegy, Dácil Alonso Gil, Stéphanie Vazquez, Karl Ekwall, Jean-Paul Javerzat   +8 more
doaj   +1 more source

Evidence for cohesin sliding along budding yeast chromosomes [PDF]

Open Biology, 2016
The ring-shaped cohesin complex is thought to topologically hold sister chromatids together from their synthesis in S phase until chromosome segregation in mitosis.
Maria Ocampo-Hafalla, Sofía Muñoz, Catarina P. Samora, Frank Uhlmann   +3 more
doaj   +1 more source

A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers. [PDF]

, 2019
Cohesin is a multiprotein ring that is responsible for cohesion of sister chromatids and formation of DNA loops to regulate gene expression. Genomic analyses have identified that the cohesin subunit STAG2 is frequently inactivated by mutations in cancer.
Ashworth, Alan, Goode, Benjamin, Mondal, Gourish, Solomon, David A, Stevers, Meredith   +4 more
core   +2 more sources

Cohesin Mutations in Cancer [PDF]

Cold Spring Harbor Perspectives in Medicine, 2016
Cohesin is a large ring-shaped protein complex, conserved from yeast to human, which participates in most DNA transactions that take place in the nucleus. It mediates sister chromatid cohesion, which is essential for chromosome segregation and homologous recombination (HR)-mediated DNA repair.
Magali, De Koninck, Ana, Losada
openaire   +2 more sources

Of Rings and Rods: Regulating Cohesin Entrapment of DNA to Generate Intra- and Intermolecular Tethers. [PDF]

PLoS Genetics, 2016
The clinical relevance of cohesin in DNA repair, tumorigenesis, and severe birth defects continues to fuel efforts in understanding cohesin structure, regulation, and enzymology.
Robert V Skibbens
doaj   +1 more source

It’s all in the numbers: Cohesin stoichiometry

Frontiers in Molecular Biosciences, 2022
Cohesin, a structural maintenance of chromosome (SMC) complex, organizes chromatin into three-dimensional structures by threading chromatin into loops and stabilizing long-range chromatin interactions. Four subunits in a 1:1:1:1 ratio compose the cohesin
Avi Matityahu, Itay Onn
doaj   +1 more source

Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions [PDF]

, 2013
During meiosis, Structural Maintenance of Chromosome (SMC) complexes underpin two fundamental features of meiosis: homologous recombination and chromosome segregation.
A Chavez, A De Muyt, A Hochwagen, A Hochwagen, A Irmisch, A McAleenan, A Schwacha, A Sourirajan, A Svetlanov, AC Chan, AJ Wood, AL Marston, Alex D. Herbert, Alice Copsey, Andreas Hochwagen, Andrew Chi-ho Chan, B Rockmill, BH Lee, C Buhler, C Tapia-Alveal, DM Sheedy, E Ampatzidou, EA Andrews, EA Outwin, ER Hoffmann, Eva Hoffmann, F Osman, FZ Watts, G De Piccoli, G Vader, GA Cromie, GR Smith, GV Borner, H Murakami, Hannah G. Blitzblau, HB Lindroos, HG Blitzblau, HG Blitzblau, HG Yu, HG Yu, I Lilienthal, J Gregan, J Matos, J Matos, J Palecek, J Pan, J Torres-Rosell, J Zalevsky, JA Carballo, JA Downs, JK Holloway, JM Murray, JR Mullen, JR Mullen, JS Bickel, K Nishimura, K Zakharyevich, K Zakharyevich, KA Henderson, KP Kim, KP Kohl, KT Nishant, L Jessop, L Jessop, L Newnham, L Wu, L Xu, LE Berchowitz, LE Hang, LJ Gaskell, Louise Newnham, M Bermudez-Lopez, M Xaver, MA Roy, Michael Lichten, MJ Neale, MN Boddy, MS McMahill, N Hunter, N Hunter, N Wu, Neil Hunter, NK Kolas, O Yildiz, P Jordan, Philip W. Jordan, PR Potts, PR Potts, Prakash Arumugam, RK Clyne, S Agarwal, S Chu, S Farmer, S Gray, S Panizza, S Pebernard, S Wehrkamp-Richter, SB Buonomo, SD Oh, SD Oh, Shangming Tang, SL Andersen, Sonya Newcombe, Stephen Gray, T de los Santos, T Snowden, T Wechsler, TM Carlile, TS Kitajima, V Kaliraman, WM Fricke, X Zhao, Y Blat, YH Chen, YH Chen, Zhaobo Li   +115 more
core   +3 more sources

Cohesin complex-associated holoprosencephaly [PDF]

Brain, 2019
AbstractMarked by incomplete division of the embryonic forebrain, holoprosencephaly is one of the most common human developmental disorders. Despite decades of phenotype-driven research, 80–90% of aneuploidy-negative holoprosencephaly individuals with a probable genetic aetiology do not have a genetic diagnosis.
Kruszka, P., Berger, S.I., Casa, V., Dekker, M.R., Gaesser, J., Weiss, K., Martinez, A.F., Murdock, D.R., Louie, R.J., Prijoles, E.J., Lichty, A.W., Brouwer, O.F., Zonneveld-Huijssoon, E., Stephan, M.J., Hogue, J., Hu, P., Tanima-Nagai, M., Everson, J.L., Prasad, C., Cereda, A., Iascone, M., Schreiber, A., Zurcher, V., Corsten-Janssen, N., Escobar, L., Clegg, N.J., Delgado, M.R., Hajirnis, O., Balasubramanian, M., Kayserili, H., Deardorff, M., Poot, R.A., Wendt, K.S., Lipinski, R.J., Muenke, M.   +34 more
openaire   +8 more sources

Recent evidence that TADs and chromatin loops are dynamic structures. [PDF]

, 2017
Mammalian genomes are folded into spatial domains, which regulate gene expression by modulating enhancer-promoter contacts. Here, we review recent studies on the structure and function of Topologically Associating Domains (TADs) and chromatin loops.
Cattoglio, Claudia, Darzacq, Xavier, Hansen, Anders, Tjian, Robert   +3 more
core   +1 more source

Spo13 regulates cohesin cleavage [PDF]

Genes & Development, 2002
A key aspect of meiotic chromosome segregation is that cohesin, the protein complex that holds sister chromatids together, dissociates from chromosome arms during meiosis I and from centromeric regions during meiosis II. The budding yeast protein Spo13 plays a key role in preventing centromeric cohesin from being lost during meiosis I.
Brian H, Lee, Angelika, Amon, Susanne, Prinz   +2 more
openaire   +2 more sources