Single-Molecule Imaging Reveals a Collapsed Conformational State for DNA-Bound Cohesin
Cell Reports, 2016 Cohesin is essential for the hierarchical organization of the eukaryotic genome and plays key roles in many aspects of chromosome biology. The conformation of cohesin bound to DNA remains poorly defined, leaving crucial gaps in our understanding of how ...
Johannes Stigler +3 more
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Epigenetics & Chromatin, 2021 Cohesin is a key organizer of chromatin folding in eukaryotic cells. The two main activities of this ring-shaped protein complex are the maintenance of sister chromatid cohesion and the establishment of long-range DNA–DNA interactions through the process
Arkadiy K. Golov +3 more
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iScience, 2023 Summary: Chromatin organization, whose malfunction causes various diseases including cancer, is fundamentally controlled by cohesin. While cancer cells have been found with mutated or misexpressed cohesin genes, there is no comprehensive survey about the
Jiankang Wang, Ryuichiro Nakato
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Complexity of the Ruminococcus flavefaciens FD-1 cellulosome reflects an expansion of family-related protein-protein interactions [PDF]
, 2017 This work was supported in part by the European Union, Area NMP.2013.1.1–2: Self-assembly of naturally occurring nanosystems: CellulosomePlus Project number: 604530, and by the EU Seventh Framework Programme (FP7 2007–2013) under the WallTraC project ...
Alves, Victor D +17 more
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CTCF mediates chromatin looping via N-terminal domain-dependent cohesin retention [PDF]
, 2020 The DNA-binding protein CCCTC-binding factor (CTCF) and the cohesin complex function together to shape chromatin architecture in mammalian cells, but the molecular details of this process remain unclear.
Kang, Sungyun +9 more
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Characteristics of Cohesin Mutation in Acute Myeloid Leukemia and Its Clinical Significance
Frontiers in Oncology, 2021 The occurrence of gene mutation is a major contributor to the initiation and propagation of acute myeloid leukemia (AML). Accumulating evidence suggests that genes encoding cohesin subunits have a high prevalence of mutations in AML, especially in the t ...
Caixia Han +6 more
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Cellulosomics, a gene-centric approach to investigating the intraspecific diversity and adaptation of Ruminococcus flavefaciens within the rumen [PDF]
, 2011 Peer reviewedPublisher ...
Bayer, Edward A +13 more
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Histone chaperone NAP1 mediates sister chromatid resolution by counteracting protein phosphatase 2A.
PLoS Genetics, 2013 Chromosome duplication and transmission into daughter cells requires the precisely orchestrated binding and release of cohesin. We found that the Drosophila histone chaperone NAP1 is required for cohesin release and sister chromatid resolution during ...
Yuri M Moshkin +9 more
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Ruminococcal cellulosome systems from rumen to human [PDF]
, 2015 This article is protected by copyright. All rights reserved. The authors appreciate the kind assistance of Miriam Lerner (ImmunArray Ltd. Company, Rehovot, Israel) with experiments involving the MicroGrid II arrayer.
Bayer, Edward A +11 more
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Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency [PDF]
, 2020 The ATM kinase is a master regulator of the DNA damage response to double-strand breaks (DSBs) and a well-established tumour suppressor whose loss is the cause of the neurodegenerative and cancer-prone syndrome Ataxia-Telangiectasia (A-T).
Bernal Lozano, Cristina +10 more
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