Results 41 to 50 of about 31,924 (248)
A multi-step pathway for the establishment of sister chromatid cohesion. [PDF]
PLoS Genetics, 2007 The cohesion of sister chromatids is mediated by cohesin, a protein complex containing members of the structural maintenance of chromosome (Smc) family. How cohesins tether sister chromatids is not yet understood.
Mark Milutinovich +4 more
doaj +1 more source
How to halve ploidy : lessons from budding yeast meiosis [PDF]
, 2012 Maintenance of ploidy in sexually reproducing organisms requires a specialized form of cell division called meiosis that generates genetically diverse haploid gametes from diploid germ cells.
Arumugam, Prakash +2 more
core +1 more source
Cohesin-dependence of neuronal gene expression relates to chromatin loop length
eLife, 2022 Cohesin and CTCF are major drivers of 3D genome organization, but their role in neurons is still emerging. Here, we show a prominent role for cohesin in the expression of genes that facilitate neuronal maturation and homeostasis.
Lesly Calderon +15 more
doaj +1 more source
Cohesin and chromosome segregation [PDF]
Current Biology, 2018 Cohesin is a ring-shaped protein complex that organises the genome, enabling its condensation, expression, repair and transmission. Cohesin is best known for its role in chromosome segregation, where it provides the cohesion that is established between the two newly duplicated sister chromatids during S phase.
Makrantoni, Vasso, Marston, Adele L
openaire +3 more sources
Cohesin regulates alternative splicing
Science Advances, 2023 Cohesin, a trimeric complex that establishes sister chromatid cohesion, has additional roles in chromatin organization and transcription. We report that among those roles is the regulation of alternative splicing through direct interactions and in situ colocalization with splicing factors.
Amit K. Singh +4 more
openaire +2 more sources
Cohesin-Mediated Chromatin Interactions and Autoimmunity
Frontiers in Immunology, 2022 Proper physiological functioning of any cell type requires ordered chromatin organization. In this context, cohesin complex performs important functions preventing premature separation of sister chromatids after DNA replication. In partnership with CCCTC-
Venkataragavan Chandrasekaran +12 more
doaj +1 more source
Principles of meiotic chromosome assembly revealed in S. cerevisiae [PDF]
, 2019 During meiotic prophase, chromosomes organise into a series of chromatin loops emanating from a proteinaceous axis, but the mechanisms of assembly remain unclear.
A Goloborodko +69 more
core +2 more sources
Cohesin and Human Disease [PDF]
Annual Review of Genomics and Human Genetics, 2008 Cornelia de Lange syndrome (CdLS) is a dominant multisystem disorder caused by a disruption of cohesin function. The cohesin ring complex is composed of four protein subunits and more than 25 additional proteins involved in its regulation. The discovery that this complex also has a fundamental role in long-range regulation of transcription in ...
Jinglan, Liu, Ian D, Krantz
openaire +2 more sources
Unique Organization of Extracellular Amylases into Amylosomes in the Resistant Starch-Utilizing Human Colonic Firmicutes Bacterium Ruminococcus bromii [PDF]
, 2015 ACKNOWLEDGMENTS We acknowledge support from BBSRC grant no. BB/L009951/1, from the Scottish government Food, Land and People program, and from the Society for Applied Microbiology. E.A.B. is supported by a grant (no.
Bayer, Edward A. +11 more
core +4 more sources
PLoS ONE, 2009 The cohesin protein complex was first recognized for holding sister chromatids together and ensuring proper chromosome segregation. Cohesin also regulates gene expression, but the mechanisms are unknown.
Cheri A Schaaf +8 more
doaj +1 more source