Results 51 to 60 of about 31,924 (248)
Securin Is Not Required for Chromosomal Stability in Human Cells [PDF]
, 2005 Abnormalities of chromosome number are frequently observed in cancers. The mechanisms regulating chromosome segregation in human cells are therefore of great interest.
Azofeifa +32 more
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Chromatin insulators and cohesins [PDF]
EMBO reports, 2008 Chromatin insulators have evolved to regulate transcription by using regulatory elements that are often distant from each other on the linear genome. This feature is position‐dependent—that is, a functional insulator must be positioned between the enhancer and its target promoter (Wallace & Felsenfeld, 2007).
Anita, Göndör, Rolf, Ohlsson
openaire +2 more sources
PLoS ONE, 2014 The immunoglobulin heavy chain locus (Igh) features higher-order chromosomal interactions to facilitate stage-specific assembly of the Ig molecule.
Gamze Günal-Sadık +5 more
doaj +1 more source
Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells
Cell Reports, 2020 Summary: How chromosome organization is related to genome function remains poorly understood. Cohesin, loop extrusion, and CCCTC-binding factor (CTCF) have been proposed to create topologically associating domains (TADs) to regulate gene expression. Here,
James D.P. Rhodes +15 more
doaj +1 more source
Cohesin interaction with centromeric minichromosomes shows a multi-complex rod-shaped structure. [PDF]
PLoS ONE, 2008 Cohesin is the protein complex responsible for maintaining sister chromatid cohesion. Cohesin interacts with centromeres and specific loci along chromosome arms known as Chromosome Attachment Regions (CARs). The cohesin holocomplex contains four subunits.
Alexandra Surcel +3 more
doaj +1 more source
Developing a peptide to disrupt cohesin head domain interactions
iScience, 2023 Summary: Cohesin mediates the 3-D structure of chromatin and is involved in maintaining genome stability and function. The cohesin core comprises Smc1 and Smc3, elongated-shaped proteins that dimerize through globular domains at their edges, called head ...
Maria Elias +9 more
doaj +1 more source
Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion [PDF]
, 2019 Genome stability involves accurate replication and DNA repair. Broken replication forks, such as those encountering a nick, lead to double strand breaks (DSBs), which are preferentially repaired by sister-chromatid recombination (SCR).
Aguilera López, Andrés +2 more
core +1 more source
The Journal of Cell Biology, 2001 ![Graphic][1] Cohesin (red) keeps centromeres together. Peters/AAAS Cohesin was a long sought-after protein complex: a glue for sister chromatids that is dissolved at the onset of anaphase thanks to cleavage of its SCC1 subunit by the protease separase.
openaire +1 more source
Cohesin loading and sliding [PDF]
Journal of Cell Science, 2011 Cohesin is best known as a crucial component of chromosomal stability. Composed of several essential subunits in budding yeast, cohesin forms a ring-like complex that is thought to embrace sister chromatids, thereby physically linking them until their timely segregation during cell division.
Maria T, Ocampo-Hafalla, Frank, Uhlmann
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Meiotic sex chromosome cohesion and autosomal synapsis are supported by Esco2.
, 2020 In mitotic cells, establishment of sister chromatid cohesion requires acetylation of the cohesin subunit SMC3 (acSMC3) by ESCO1 and/or ESCO2. Meiotic cohesin plays additional but poorly understood roles in the formation of chromosome axial elements (AEs)
Biswas, U. +6 more
core +1 more source