Results 71 to 80 of about 31,924 (248)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

A single cohesin complex performs mitotic and meiotic functions in the protist tetrahymena.

PLoS Genetics, 2013
The cohesion of sister chromatids in the interval between chromosome replication and anaphase is important for preventing the precocious separation, and hence nondisjunction, of chromatids.
Rachel A Howard-Till, Agnieszka Lukaszewicz, Maria Novatchkova, Josef Loidl   +3 more
doaj   +1 more source

Drosophila TDP-43 RNA-Binding Protein Facilitates Association of Sister Chromatid Cohesion Proteins with Genes, Enhancers and Polycomb Response Elements. [PDF]

PLoS Genetics, 2016
The cohesin protein complex mediates sister chromatid cohesion and participates in transcriptional control of genes that regulate growth and development.
Amanda Swain, Ziva Misulovin, Michelle Pherson, Maria Gause, Kathie Mihindukulasuriya, Ryan A Rickels, Ali Shilatifard, Dale Dorsett   +7 more
doaj   +1 more source

STAG2 promotes the myelination transcriptional program in oligodendrocytes

eLife, 2022
Cohesin folds chromosomes via DNA loop extrusion. Cohesin-mediated chromosome loops regulate transcription by shaping long-range enhancer–promoter interactions, among other mechanisms.
Ningyan Cheng, Guanchen Li, Mohammed Kanchwala, Bret M Evers, Chao Xing, Hongtao Yu   +5 more
doaj   +1 more source

Chromatin association of the SMC5/6 complex is dependent on binding of its NSE3 subunit to DNA [PDF]

, 2015
SMC5/6 is a highly conserved protein complex related to cohesin and condensin, which are the key components of higher-order chromatin structures. The SMC5/6 complex is essential for proliferation in yeast and is involved in replication fork stability and
Adamus, Marek, Alt, Aaron, Jurcisinova, Lenka, Lehmann, Alan R, Liao, Chunyan, Novakova, Marketa, Oliver, Antony W, Palecek, Jan J, Skoupilova, Hana, Vondrova, Lucie, Zabrady, Katerina   +10 more
core   +2 more sources

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Unraveling the cohesin-chromatin interface: identifying protein interactions that modulate chromosome structure and function

Epigenetics & Chromatin
Background The evolutionarily conserved cohesin complex is a pleiotropic regulator of chromosome structure and function, participating in sister chromatid cohesion, transcriptional regulation of genes, DNA replication, and DNA repair.
Natalie L. Rittenhouse, Riya Gohil, June E. Arricastres, Jill M. Dowen   +3 more
doaj   +1 more source

Secretion and assembly of functional mini-cellulosomes from synthetic chromosomal operons in Clostridium acetobutylicum ATCC 824. [PDF]

, 2013
Background: Consolidated bioprocessing (CBP) is reliant on the simultaneous enzyme production, saccharification of biomass, and fermentation of released sugars into valuable products such as butanol. Clostridial species that produce butanol are, however,
Bolam, DN, Heap, JT, Jackson, A, Kovács, K, Minton, NP, Schwarz, K, Willson, BJ, Winzer, K   +7 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Cohesin and chromatin organisation

Current Opinion in Genetics & Development, 2012
Cohesin defines the topology of chromosomes in mitosis and meiosis by holding sister chromatids together; more recently a role for cohesin in chromatin organisation and gene expression in interphase has emerged.
Seitan, VC, Merkenschlager, M
openaire   +4 more sources