Results 1 to 10 of about 77,384 (244)

Colchicine and the heart [PDF]

European Heart Journal, 2021
Abstract Colchicine is a unique, sophisticated anti-inflammatory agent that has been used for decades for the prevention of acute inflammatory flares in gout and familial Mediterranean fever. In recent years, clinical trials have demonstrated its potential in a range of cardiovascular (CV) conditions.
Massimo Imazio, Mark Nidorf
openaire   +4 more sources

Colchicine Impacts Leukocyte Trafficking in Atherosclerosis and Reduces Vascular Inflammation

Frontiers in Immunology, 2022
BackgroundInflammation strongly contributes to atherosclerosis initiation and progression. Consequently, recent clinical trials pharmacologically targeted vascular inflammation to decrease the incidence of atherosclerosis-related complications ...
Ulrike Meyer-Lindemann, Ulrike Meyer-Lindemann, Carina Mauersberger, Carina Mauersberger, Anna-Christina Schmidt, Anna-Christina Schmidt, Aldo Moggio, Julia Hinterdobler, Julia Hinterdobler, Xinghai Li, David Khangholi, David Khangholi, Jan Hettwer, Jan Hettwer, Christian Gräßer, Christian Gräßer, Alexander Dutsch, Alexander Dutsch, Heribert Schunkert, Heribert Schunkert, Thorsten Kessler, Thorsten Kessler, Hendrik B. Sager, Hendrik B. Sager   +23 more
doaj   +2 more sources

Beneficial effects of colchicine for moderate to severe COVID-19: a randomised, double-blinded, placebo-controlled clinical trial

RMD Open, 2021
Objective To evaluate whether the addition of colchicine to standard treatment for COVID-19 results in better outcomes.Design We present the results of a randomised, double-blinded, placebo-controlled clinical trial of colchicine for the treatment of ...
Maria Isabel Lopes, Leticia P Bonjorno, Marcela C Giannini, Natalia B Amaral, Pamella Indira Menezes, Saulo Musse Dib, Samara Libich Gigante, Maira N Benatti, Uebe C Rezek, Laerte L Emrich-Filho, Betania A A Sousa, Sergio C L Almeida, Rodrigo Luppino Assad, Flavio P Veras, Ayda Schneider, Tamara S Rodrigues, Luiz O S Leiria, Larissa D Cunha, Jose C Alves-Filho, Thiago M Cunha, Eurico Arruda, Carlos H Miranda, Antonio Pazin-Filho, Maria Auxiliadora-Martins, Marcos C Borges, Benedito A L Fonseca, Valdes R Bollela, Cristina M Del-Ben, Fernando Q Cunha, Dario S Zamboni, Rodrigo C Santana, Fernando C Vilar, Paulo Louzada-Junior, Rene D R Oliveira   +33 more
doaj   +2 more sources

Colchicine for pericarditis [PDF]

Cochrane Database of Systematic Reviews, 2014
Pericarditis is the inflammation of the pericardium, the membranous sac surrounding the heart. Recurrent pericarditis is the most common complication of acute pericarditis, causing severe and disabling chest pains. Recurrent pericarditis affects one in three patients with acute pericarditis within the first 18 months.
Alabed, S, Cabello, J, Irving, G, Qintar, M, Burls, A   +4 more
openaire   +7 more sources

Network Pharmacology-Based Investigation and Experimental Exploration of the Antiapoptotic Mechanism of Colchicine on Myocardial Ischemia Reperfusion Injury

Frontiers in Pharmacology, 2021
Background: The beneficial effects of colchicine on cardiovascular disease have been widely reported in recent studies. Previous research demonstrated that colchicine has a certain protective effect on ischemic myocardium and has the potential to treat ...
Yuanjun Tang, Chenyang Shi, Yingyi Qin, Shuowen Wang, Hui Pan, Ming Chen, Xuemei Yu, Yuefen Lou, Guorong Fan   +8 more
doaj   +1 more source

Therapeutic potential of colchicine in cardiovascular medicine: a pharmacological review

Acta Pharmacologica Sinica, 2022
Colchicine is an ancient herbal drug derived from Colchicum autumnale. It was first used to treat familial Mediterranean fever and gout. Based on its unique efficacy as an anti-inflammatory agent, colchicine has been used in the therapy of cardiovascular
Fan Zhang, Qing-ze He, C. Qin, P. Little, Jian-ping Weng, Suo Xu   +5 more
semanticscholar   +1 more source

Effect of Colchicine on Secondary Acute Lung Injury in an Experimental Sepsis Model in Rats

Mediterranean Journal of Infection, Microbes and Antimicrobials, 2023
Introduction: An irregular systemic inflammatory response in sepsis can induce acute lung injury (ALI), which is characterized by the exaggerated inflammation of the lung tissue.
Mehmet CEYLAN, Şükran KÖSE, Hüseyin Oğuz YILMAZ, Safiye AKTAŞ, Osman YILMAZ   +4 more
doaj   +1 more source

In Vitro Induction and Identification of Polyploid Amorphophallus muelleri Blume Plants by Colchicine Treatment

AGRIVITA Journal of Agricultural Science, 2023
This research aimed to induce in vitro and identify polyploidy plantlets of Porang (Amorphophallus muelleri Blume) after colchicine treatment.
Wahyu Widoretno, Rodliyati Azriningsih, Deden Sukmadjaja, Mufidatur Rosyidah   +3 more
doaj   +1 more source

Colchicine Is a Weapon for Managing the Heart Disease Among Interstitial Lung Disease With Viral Infection: Have We Found the Holy Grail?

Frontiers in Cardiovascular Medicine, 2022
BackgroundThis study investigated the effect of colchicine use on the risks of heart disease (HD), pericarditis, endocarditis, myocarditis, cardiomyopathy, cardiac arrhythmia, and cardiac failure in patients having interstitial lung disease (ILD) with ...
Jun-Jun Yeh, Jun-Jun Yeh, Tuey-Wen Hung, Cheng-Li Lin, Cheng-Li Lin, Tsung-Tse Chen, Pei-Xuan Liw, Ya-Lun Yu, Chia-Hung Kao, Chia-Hung Kao, Chia-Hung Kao, Chia-Hung Kao   +11 more
doaj   +1 more source

Inhibition of the Glycine Receptor alpha 3 Function by Colchicine

Frontiers in Pharmacology, 2020
Colchicine is a plant alkaloid that is widely used as a therapeutic agent. It is widely accepted that colchicine reduces the production of inflammatory mediators mainly by altering cytoskeleton dynamics due to its microtubule polymerization inhibitory ...
Carola Muñoz-Montesino, Carlos F. Burgos, Cesar O. Lara, Camila R. Riquelme, David Flaig, Victoria P. San Martin, Luis G. Aguayo, Jorge Fuentealba, Patricio A. Castro, Leonardo Guzmán, Gonzalo E. Yévenes, Gustavo Moraga-Cid   +11 more
doaj   +1 more source