Results 111 to 120 of about 45,519 (269)

Phase IIb Trial for the Palliative Treatment of Patients With Primary Hepatic Malignancy Unable to Receive Curative Treatment: Efficacy of Colchicine

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This trial was to evaluate the efficacy and the safety of colchicine for the palliative treatment of patients with primary hepatic malignancy unable to receive curative treatment. Forty hepatocellular carcinoma (HCC) patients and two intrahepatic cholangiocarcinoma (ICC) patients signed the informed consents.
Zu‐Yau Lin, Ming‐Lun Yeh, Po‐Cheng Liang, Shinn‐Cherng Chen, Chung‐Feng Huang, Jee‐Fu Huang, Chia‐Yen Dai, Ming‐Lung Yu, Wan‐Long Chuang   +8 more
wiley   +1 more source

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

The role of physical exercise in diseases treated with colchicine - an ancient drug with novel clinical applications

Quality in Sport
Colchicine, a lipid-soluble alkaloid derived from Colchicum autumnale, has a long history of use dating back to ancient Egypt. Traditionally used to alleviate pain and swelling, colchicine is now administered for various diseases, including gout and ...
Julia Rejdych, Katarzyna Podyma, Sara Rosołowska-Żak, Maria Sambura, Wiktoria Sas, Gracja Ryznar, Piotr Pierzchała, Michalina Minkowska, Krystyna Chimiak, Gabriela Bylica   +9 more
doaj   +1 more source

Structure of Colchicine [PDF]

Nature, 1945
IN view of the remarkable physiological properties of colchicine its chemical nature is of some interest. Until recently, the structure (I) proposed by Windaus1 has been generally accepted, although the stability of colchicine did not suggest a 9-amino-9: 10-dihydrophenanthrene system, and although the salicylaldehyde enol structure of ring C appeared ...
openaire   +4 more sources

Colchicine Overdose in a Suicidal Attempt [PDF]

International Journal of Medical Toxicology and Forensic Medicine, 2019
Colchicine overdose is uncommon; however, it can cause serious adverse effects and even death. Colchicine inhibits microtubule polymerization, causing mitotic spindle disruption.
Fatemeh Eghbali, Reza Bidaki, Sina Negintaji, Maryam Dehghani, Adeleh Sahebnasagh, Ali Asghar Bagheri Atabak, Fatemeh Saghafi   +6 more
doaj  

The conversion of colchicine into colchiceine [PDF]

, 1938
Eric Boyland, Elinor Huntsman Mawson
openalex   +1 more source

Taxonomy and dated molecular phylogeny of Allium oreophilum sensu lato (A. subg. Porphyroprason) uncover a surprising number of cryptic taxa

TAXON, EarlyView.
Abstract Allium oreophilum, hitherto the representative of the monotypic A. subg. Porphyroprason from the second evolutionary lineage of Allium, is studied in detail. Over about 150 years, A. oreophilum was regarded as a somewhat polymorphous species with two synonyms, all described in the 19th century.
Nikolai Friesen, Georgy Lazkov, Igor G. Levichev, Mathias Leweke, Daulet Abdildanov, Nazgul Turdumatova, Ramazan Murtazaliev, Smatula Dzumanov, Gulnara T. Sitpayeva, Polina Vesselova, Vladimir Epiktetov, Kuddisi Ertuğrul, Osman Tugay, Reinhard M. Fritsch   +13 more
wiley   +1 more source

Hemophagocytic lymphohistiocytosis and Pelger-Huët anomaly associated with colchicine intoxication

Hematology Reports, 2014
Colchicine is frequently used in the treatment of familial Mediterranean fever (FMF). First symptoms of colchicine intoxication are gastrointestinal disturbances, such as abdominal cramps, diarrhea, pancytopenia and so on.
Baris Malbora, Emine Polat, Sare Gulfem Akyuz   +2 more
doaj   +1 more source

European Society for the Study of Coeliac Disease 2025 Updated Guidelines on the Diagnosis and Management of Coeliac Disease in Adults. Part 1: Diagnostic Approach

United European Gastroenterology Journal, EarlyView.
Infographic. This infographic summarizes the diagnostic approach to CeD in adults, including initial serological testing, histological confirmation, criteria for a no‐biopsy diagnosis, seronegative CeD, potential CeD, and the role of gluten challenge. Source: Authors' own creation (based on current clinical guidelines).
Abdulbaqi Al‐Toma, Fabiana Zingone, Federica Branchi, Annalisa Schiepatti, Georgia Malamut, Cristina Canova, Isabella Rosato, Honoria Ocagli, Nick Trott, Luca Elli, Alina Popp, Carmen Gianfrani, Renata Auricchio, Andra Neefjes‐Borst, David S. Sanders, Christophe Cellier, Chris J. Mulder, Gerd Bouma, Knut E. A. Lundin, Ludvig M. Sollid, Michael Schumann   +20 more
wiley   +1 more source

Colchicine and the Heart

Journal of the American College of Cardiology, 2013
Colchicine, a natural and ancient drug still used today, is traditionally considered the staple therapy for gout and a second-line treatment for pericarditis, as well as a basic part of familial Mediterranean fever and Behcet's disease management. It is commonly classified as an anti-inflammatory agent, although its mechanism of action does not involve
Charalampos Kossyvakis, Spyridon Deftereos, Michael W. Cleman, Konstantinos Raisakis, Georgios Giannopoulos, Nikolaos Papoutsidakis, Christodoulos Stefanadis, Vasiliki Panagopoulou   +7 more
openaire   +3 more sources