Results 121 to 130 of about 45,519 (269)

Roflumilast for Oral Ulcers in Behçet's Disease and Recurrent Aphthous Stomatitis

open access: yesThe Journal of Dermatology, EarlyView.
ABSTRACT Oral aphthous ulcer in Behçet's disease (BD) and recurrent aphthous stomatitis (RAS) is a cause of discomfort for many patients, especially in cases refractory to colchicine or azathioprine. Roflumilast, a phosphodiesterase‐4 (PDE4) inhibitor, may be effective for treating refractory oral ulcers (OUs) in BD and RAS, especially in regions where
Kyung Bae Chung   +4 more
wiley   +1 more source

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen   +3 more
wiley   +1 more source

Colchicine in acute gout

open access: yesBMJ, 2003
We describe three histories of patients with gout who were treated with doses of colchicine as advised by the British National Formulary (BNF)–that is, 1 mg initially followed by 500 μg every 2-3 hours until relief of pain is obtained or vomiting or diarrhoea occurs or until a total dose of 6 mg has been reached; the course should not be repeated ...
George I. Varughese   +2 more
openaire   +3 more sources

A Multicenter Observational Study for the Establishment of Novel Severity Criteria Including Endoscopic Evaluation for Intestinal Behçet's Disease

open access: yesDigestive Endoscopy, EarlyView.
The establishment of novel severity criteria for intestinal Behçet's disease. ABSTRACT Objective This study aimed to establish a novel severity classification for intestinal Behçet's disease (BD) (SCIBD) and validate its criteria across multiple institutions.
Toshiro Fukui   +20 more
wiley   +1 more source

Repurposing colchicine for reduction of residual inflammatory risk in type 1 diabetes: Design and rationale of the REC1TE trial

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Compared to people without diabetes, individuals with type 1 diabetes have a several‐fold increased risk of cardiovascular (CV) morbidity and mortality despite guideline‐recommended management of traditional risk factors; so‐called residual CV risk.
David S. Mathiesen   +13 more
wiley   +1 more source

Educational level, clinical outcomes and quality of care in a Swiss cohort of patients with acute coronary syndromes

open access: yesEuropean Journal of Clinical Investigation, EarlyView.
Despite universal healthcare in Switzerland, disparities in post‐acute coronary syndrome (ACS) care persist across educational levels. In a cohort of 6040 patients, those with the lowest education had more cardiovascular risk factors and were less likely to attend cardiac rehabilitation or receive cardiology follow‐up.
Maëlle Achard   +14 more
wiley   +1 more source

Clinicopathological Challenge: A Progressively Enlarging Hardened Skin Plaque

open access: yesInternational Journal of Dermatology, EarlyView.
ABSTRACT Stiff skin syndrome (SSS) is a rare connective tissue disease manifesting as a progressive, non‐inflammatory fibrosis that causes the skin and soft tissues to harden. It can result in restricted joint movement, particularly affecting the shoulder and pelvic girdle. A segmental variant with a better prognosis has been described.
Marian Fernández Martínez   +3 more
wiley   +1 more source

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