Results 11 to 20 of about 50,322 (265)

Colchicine reduces atherosclerotic plaque vulnerability in rabbits

Atherosclerosis Plus, 2021
Background and aims: The anti-inflammatory agent colchicine is gaining interest as a treatment for coronary artery disease. However, the effects of colchicine in atherosclerotic animal models are mostly unknown. This study aimed to evaluate colchicine in
François Roubille, Nolwenn Merlet, David Busseuil, Marine Ferron, Yanfen Shi, Teodora Mihalache-Avram, Mélanie Mecteau, Geneviève Brand, Daniel Rivas, Mariève Cossette, Marie-Claude Guertin, Eric Rhéaume, Jean-Claude Tardif   +12 more
doaj   +1 more source

High colchicine doses are more effective in COVID-19 outpatients than nirmatrelvir/ritonavir, remdesivir, and molnupiravir [PDF]

Pharmacia
Colchicine has an excellent basis for being effective against COVID-19 due to its anti-inflammatory, immunomodulatory, and cardioprotective effects, as well as its role in preventing microvascular thrombosis.
Vanyo Mitev, Krasimir Marinov, Rumen Tiholov, Konstantin Tachkov, Radoslav Bilyukov, Aleksander I. Lilov, Kiril R. Palaveev, Ani Miteva, Iva Miteva, Violeta S. Dimitrova, Nikolay Ishkitiev, Tsanko Mondeshki   +11 more
doaj   +3 more sources

Colchicine Impacts Leukocyte Trafficking in Atherosclerosis and Reduces Vascular Inflammation

Frontiers in Immunology, 2022
BackgroundInflammation strongly contributes to atherosclerosis initiation and progression. Consequently, recent clinical trials pharmacologically targeted vascular inflammation to decrease the incidence of atherosclerosis-related complications ...
Ulrike Meyer-Lindemann, Ulrike Meyer-Lindemann, Carina Mauersberger, Carina Mauersberger, Anna-Christina Schmidt, Anna-Christina Schmidt, Aldo Moggio, Julia Hinterdobler, Julia Hinterdobler, Xinghai Li, David Khangholi, David Khangholi, Jan Hettwer, Jan Hettwer, Christian Gräßer, Christian Gräßer, Alexander Dutsch, Alexander Dutsch, Heribert Schunkert, Heribert Schunkert, Thorsten Kessler, Thorsten Kessler, Hendrik B. Sager, Hendrik B. Sager   +23 more
doaj   +1 more source

Anticancer effects of clinically acceptable colchicine concentrations on human gastric cancer cell lines

Kaohsiung Journal of Medical Sciences, 2016
Colchicine is a very cheap microtubule destabilizer. Because microtubules are an ideal target for anticancer drugs, the purpose of this study was to investigate whether clinically acceptable colchicine concentrations have anticancer effects on gastric ...
Zu-Yau Lin, Chao-Hung Kuo, Deng-Chyang Wu, Wan-Long Chuang   +3 more
doaj   +1 more source

Case Report: Colchicine Toxicokinetic Analysis in a Poisoned Child Requiring Extracorporeal Life Support

Frontiers in Pediatrics, 2021
Colchicine poisoning is associated with a poor prognosis, especially when leading to shock and multi-organ failure, and management is limited to supportive care, including multiple-dose activated charcoal.
Maria Pérez Marín, Sylvain Prod'hom, Suzanne Francesca de Villiers, Thomas Ferry, Vivianne Amiet, Julia Natterer, Maria-Helena Perez, Thierry Buclin, Haithem Chtioui, David Longchamp   +9 more
doaj   +1 more source

Destabilising microtubule polymerization regulates chondrocyte dedifferentiation and inflammation via nuclear factor kappa b and β-catenin pathway

Bangladesh Journal of Pharmacology, 2023
The role of cell morphological changes in colchicine-inhibited tubulin polymerization of rabbit articular chondrocytes and their involvement in dedifferentiation were investigated.
Yohan Han, Young Seok Eom, Fahad Hassan Shah, Song Ja Kim   +3 more
doaj   +1 more source

In silico study of colchicine resistance molecular mechanisms caused by tubulin structural polymorphism.

PLoS ONE, 2019
Starting from 1972, colchicine is known as the most useful drug for prevention of familial Mediterranean fever attacks. However, some patients do not respond to colchicine treatment, even taken in high doses.
Harutyun Sahakyan, Narek Abelyan, Vahram Arakelov, Grigor Arakelov, Karen Nazaryan   +4 more
doaj   +1 more source

Biorhizome: A Biosynthetic Platform for Colchicine Biomanufacturing

Frontiers in Plant Science, 2017
Colchicine is one of the oldest plant-based medicines used to treat gout and one of the most important alkaloid-based antimitotic drugs with anticancer potential, which is commercially extracted from Gloriosa superba.
Ganapathy Sivakumar, Kamran Alba, Gregory C. Phillips   +2 more
doaj   +1 more source

Reducing length of hospital stay with colchicine

Journal of Infection in Developing Countries, 2022
Introduction: Colchicine is an ancient agent with well-known anti-inflammatory effects and commonly used in treatment of hyperinflammatory conditions.
Özlem Karakaş, Abdulsamet Erden, Serdar Can Güven, Berkan Armağan, Enes Seyda Sahiner, Ali Can Kurtipek, Osman Inan, Emin Gemcioglu, İhsan Ateş, Ahmet Omma, Orhan Küçüksahin   +10 more
doaj   +1 more source

Colchicine in Neurosurgery

Current Pharmaceutical Design, 2018
Background: Colchicine is an ancient drug. Many uses have been reported in medical books and reports through the centuries. Currently the understanding of its mechanism of action has opened new horizons to its use. Objective: This article aims to discuss the use of colchicine in various neurosurgical conditions.
Drosos, E., Giakoumettis, D., Themistocleous, M.S.   +2 more
openaire   +3 more sources