Results 11 to 20 of about 77,446 (306)

Colchicine in Patients with Chronic Coronary Disease.

New England Journal of Medicine, 2020
BACKGROUND Evidence from a recent trial has shown that the antiinflammatory effects of colchicine reduce the risk of cardiovascular events in patients with recent myocardial infarction, but evidence of such a risk reduction in patients with chronic ...
S. Nidorf, A. Fiolet, A. Mosterd, J. Eikelboom, A. Schut, T. Opstal, Salem H K The, Xiao-fang Xu, M. Ireland, T. Lenderink, D. Latchem, P. Hoogslag, Anastazia Jerzewski, P. Nierop, A. Whelan, R. Hendriks, H. Swart, J. Schaap, A. Kuijper, M. V. van Hessen, P. Saklani, Isabel Tan, A. Thompson, A. Morton, C. Judkins, W. Bax, M. Dirksen, M. Alings, G. Hankey, C. Budgeon, J. Tijssen, J. Cornel, P. Thompson   +32 more
semanticscholar   +1 more source

Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospitalized With Coronavirus Disease 2019

JAMA Network Open, 2020
Key Points Question Is the receipt of colchicine among patients hospitalized with symptomatic coronavirus disease 2019 associated with clinical benefit?
S. Deftereos, G. Giannopoulos, D. Vrachatis, G. Siasos, S. Giotaki, P. Gargalianos, S. Metallidis, G. Sianos, S. Baltagiannis, P. Panagopoulos, Konstantinos Dolianitis, Efthalia Randou, K. Syrigos, A. Kotanidou, N. Koulouris, H. Milionis, N. Sipsas, C. Gogos, G. Tsoukalas, C. Olympios, E. Tsagalou, I. Migdalis, S. Gerakari, C. Angelidis, D. Alexopoulos, P. Davlouros, G. Hahalis, I. Kanonidis, D. Katritsis, T. Kolettis, A. Manolis, L. Michalis, K. Naka, V. Pyrgakis, K. Toutouzas, F. Triposkiadis, K. Tsioufis, E. Vavouranakis, L. Martínez-Dolz, B. Reimers, G. Stefanini, M. Cleman, J. Goudevenos, S. Tsiodras, D. Tousoulis, E. Iliodromitis, R. Mehran, G. Dangas, C. Stefanadis   +48 more
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Radioimmunoassay of colchicine [PDF]

Biochemical Journal, 1975
Antibodies to cholchicine were raised in rabbits after injection of N-desacetylthiocolchicine conjugated to bovine serum albumin. Antisera diluted 1:100 bound 50% of 1.6ng of [3H]colchicine. Cross-reaction of the antisera with colchicine derivatives and other drugs was measured and a radioimmunoassay of colchicine in biological fluids was proposed.
Duprey F, Bohuon C, Boudène C
openaire   +3 more sources

Effect of Colchicine on Myocardial Injury in Acute Myocardial Infarction

Circulation, 2021
Supplemental Digital Content is available in the text. Background: Inflammation is a key factor of myocardial damage in reperfused ST-segment–elevation myocardial infarction.
N. Mewton, F. Roubille, D. Bresson, C. Prieur, C. Bouleti, T. Bochaton, F. Ivanes, O. Dubreuil, L. Bière, A. Hayek, F. Dérimay, Mariama Akodad, B. Alos, Lamis Haider, Naoual El Jonhy, Rachel Daw, C. de Bourguignon, C. Dhelens, G. Finet, E. Bonnefoy-cudraz, G. Bidaux, F. Boutitie, D. Maucort-Boulch, P. Croisille, G. Rioufol, F. Prunier, D. Angoulvant   +26 more
semanticscholar   +1 more source

Efficacy of Colchicine in Non-Hospitalized Patients with COVID-19

medRxiv, 2021
Background Evidence suggests the role of an inflammatory storm in COVID-19 complications. Colchicine is an orally administered, anti-inflammatory medication beneficial in gout, pericarditis and coronary disease.
J. Tardif, N. Bouabdallaoui, P. L’allier, D. Gaudet, B. Shah, M. Pillinger, J. López-Sendón, P. D. Da Luz, L. Verret, S. Audet, J. Dupuis, A. Denault, M. Pelletier, P. Tessier, S. Samson, D. Fortin, J. Tardif, D. Busseuil, E. Goulet, C. Lacoste, A. Dubois, A. Joshi, D. Waters, P. Hsue, N. Lepor, F. Lesage, N. Sainturet, E. Roy-Clavel, Z. Bassevitch, A. Orfanos, J. Grégoire, L. Busque, C. LaVallee, P. Hétu, Jean-Sébastien Paquette, S. Lévesque, M. Cossette, A. Nozza, M. Chabot-Blanchet, M. Dubé, M. Guertin, G. Boivin   +41 more
semanticscholar   +1 more source

Colchicine and gout [PDF]

Arthritis & Rheumatism, 1991
The purpose of this discussion is to examine these two concerns, the efficacy and safety of colchicine, in the context of this controversy.
Gene V. Ball, Larry W. Moreland
openaire   +3 more sources

Colchicine in Patients with Acute Coronary Syndrome: The Australian COPS Randomized Clinical Trial.

Circulation, 2020
Background: Inflammation plays a crucial role in clinical manifestations and complications of acute coronary syndromes (ACS).
D. Tong, S. Quinn, A. Nasis, C. Hiew, P. Roberts-Thomson, H. Adams, R. Sriamareswaran, N. Htun, W. Wilson, D. Stub, W. van Gaal, L. Howes, N. Collins, A. Yong, R. Bhindi, R. Whitbourn, Astin K Y Lee, C. Hengel, K. Asrress, M. Freeman, J. Amerena, Andrew M. Wilson, J. Layland   +22 more
semanticscholar   +1 more source

Time-to-treatment initiation of colchicine and cardiovascular outcomes after myocardial infarction in the Colchicine Cardiovascular Outcomes Trial (COLCOT)

European Heart Journal, 2020
Aims The COLchicine Cardiovascular Outcomes Trial (COLCOT) demonstrated the benefits of targeting inflammation after myocardial infarction (MI). We aimed to determine whether time-to-treatment initiation (TTI) influences the beneficial impact of ...
N. Bouabdallaoui, J. Tardif, D. Waters, F. Pinto, A. Maggioni, R. Diaz, C. Berry, W. Koenig, J. López-Sendón, H. Gamra, G. Kiwan, L. Blondeau, Andreas Orfanos, R. Ibrahim, J. Grégoire, M. Dubé, M. Samuel, O. Morel, P. Lim, O. Bertrand, S. Kouz, M. Guertin, P. L’allier, F. Roubille   +23 more
semanticscholar   +1 more source

The Ugly Side of Colchicine [PDF]

Journal of Investigative Medicine High Impact Case Reports, 2021
We report a rare case of a 32-year-old male who ingested 32.4 to 54 mg of colchicine and presented after 44 hours. He developed progressive multiple organ failure with shock, acute kidney failure, troponemia, pancytopenia, absolute neutropenia, disseminated intravascular coagulation, acute liver failure, rhabdomyolysis, and lactic acidosis.
Justin Cozza, Tuong Vi Cassandra Do, Shyam Ganti, Jayaramakrishna Depa   +3 more
openaire   +3 more sources

The Association Between Usage of Colchicine and Pneumonia: A Nationwide, Population-Based Cohort Study

Frontiers in Pharmacology, 2019
Objectives: A previous study suggested that colchicine may cause leukopenia and increase the risk of infection, such as pneumonia. Thus, we investigated the potential relationship between colchicine use and risk of developing pneumonia.Methods: Data were
Tsung-Lin Tsai, James Cheng-Chung Wei, James Cheng-Chung Wei, James Cheng-Chung Wei, Yue-Ting Wu, Yueh-Han Ku, Kun-Lin Lu, Yu-Hsun Wang, Jeng-Yuan Chiou   +8 more
doaj   +1 more source