Results 21 to 30 of about 45,519 (269)

Efficacy of Colchicine in Non-Hospitalized Patients with COVID-19

medRxiv, 2021
Background Evidence suggests the role of an inflammatory storm in COVID-19 complications. Colchicine is an orally administered, anti-inflammatory medication beneficial in gout, pericarditis and coronary disease.
J. Tardif, N. Bouabdallaoui, P. L’allier, D. Gaudet, B. Shah, M. Pillinger, J. López-Sendón, P. D. Da Luz, L. Verret, S. Audet, J. Dupuis, A. Denault, M. Pelletier, P. Tessier, S. Samson, D. Fortin, J. Tardif, D. Busseuil, E. Goulet, C. Lacoste, A. Dubois, A. Joshi, D. Waters, P. Hsue, N. Lepor, F. Lesage, N. Sainturet, E. Roy-Clavel, Z. Bassevitch, A. Orfanos, J. Grégoire, L. Busque, C. LaVallee, P. Hétu, Jean-Sébastien Paquette, S. Lévesque, M. Cossette, A. Nozza, M. Chabot-Blanchet, M. Dubé, M. Guertin, G. Boivin   +41 more
semanticscholar   +1 more source

High colchicine doses are more effective in COVID-19 outpatients than nirmatrelvir/ritonavir, remdesivir, and molnupiravir [PDF]

Pharmacia
Colchicine has an excellent basis for being effective against COVID-19 due to its anti-inflammatory, immunomodulatory, and cardioprotective effects, as well as its role in preventing microvascular thrombosis.
Vanyo Mitev, Krasimir Marinov, Rumen Tiholov, Konstantin Tachkov, Radoslav Bilyukov, Aleksander I. Lilov, Kiril R. Palaveev, Ani Miteva, Iva Miteva, Violeta S. Dimitrova, Nikolay Ishkitiev, Tsanko Mondeshki   +11 more
doaj   +3 more sources

Colchicine in Patients with Acute Coronary Syndrome: The Australian COPS Randomized Clinical Trial.

Circulation, 2020
Background: Inflammation plays a crucial role in clinical manifestations and complications of acute coronary syndromes (ACS).
D. Tong, S. Quinn, A. Nasis, C. Hiew, P. Roberts-Thomson, H. Adams, R. Sriamareswaran, N. Htun, W. Wilson, D. Stub, W. van Gaal, L. Howes, N. Collins, A. Yong, R. Bhindi, R. Whitbourn, Astin K Y Lee, C. Hengel, K. Asrress, M. Freeman, J. Amerena, Andrew M. Wilson, J. Layland   +22 more
semanticscholar   +1 more source

Pengaruh Manipulasi Ploidi Terhadap Efektivitas Pertumbuhan dan Hasil Tanaman Labu Kuning (Cucurbita moschene Dutchene)

Rekayasa, 2023
Pumpkin (Cucurbita moschene Duthene) is plant sources of food that has high nutrition content. Increasing the productivity of pumpkin can be done through programs, which is the ploidy manipulation technique, the technique using a mutagen, namely ...
Reza Prakoso Dwi Julianto, I Made Indra Agastya, Wahyu Fikrinda   +2 more
doaj   +1 more source

Colchicine in overdose [PDF]

British Journal of General Practice, 2017
We read with interest the letter from Lloyd warning of the danger of colchicine overdose1 and agree that this can have devastating consequences. However, the …
Christian D Mallen, Edward Roddy
openaire   +3 more sources

Time-to-treatment initiation of colchicine and cardiovascular outcomes after myocardial infarction in the Colchicine Cardiovascular Outcomes Trial (COLCOT)

European Heart Journal, 2020
Aims The COLchicine Cardiovascular Outcomes Trial (COLCOT) demonstrated the benefits of targeting inflammation after myocardial infarction (MI). We aimed to determine whether time-to-treatment initiation (TTI) influences the beneficial impact of ...
N. Bouabdallaoui, J. Tardif, D. Waters, F. Pinto, A. Maggioni, R. Diaz, C. Berry, W. Koenig, J. López-Sendón, H. Gamra, G. Kiwan, L. Blondeau, Andreas Orfanos, R. Ibrahim, J. Grégoire, M. Dubé, M. Samuel, O. Morel, P. Lim, O. Bertrand, S. Kouz, M. Guertin, P. L’allier, F. Roubille   +23 more
semanticscholar   +1 more source

Destabilising microtubule polymerization regulates chondrocyte dedifferentiation and inflammation via nuclear factor kappa b and β-catenin pathway

Bangladesh Journal of Pharmacology, 2023
The role of cell morphological changes in colchicine-inhibited tubulin polymerization of rabbit articular chondrocytes and their involvement in dedifferentiation were investigated.
Yohan Han, Young Seok Eom, Fahad Hassan Shah, Song Ja Kim   +3 more
doaj   +1 more source

Anticancer effects of clinically acceptable colchicine concentrations on human gastric cancer cell lines

Kaohsiung Journal of Medical Sciences, 2016
Colchicine is a very cheap microtubule destabilizer. Because microtubules are an ideal target for anticancer drugs, the purpose of this study was to investigate whether clinically acceptable colchicine concentrations have anticancer effects on gastric ...
Zu-Yau Lin, Chao-Hung Kuo, Deng-Chyang Wu, Wan-Long Chuang   +3 more
doaj   +1 more source

COLCHICINE [PDF]

The Journal of Nervous and Mental Disease, 1876
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openaire   +1 more source

Discovery and engineering of colchicine alkaloid biosynthesis

Nature, 2020
Few complete pathways have been established for the biosynthesis of medicinal compounds from plants. Accordingly, many plant-derived therapeutics are isolated directly from medicinal plants or plant cell culture1.
Ryan S. Nett, Warren Lau, Elizabeth S. Sattely   +2 more
semanticscholar   +1 more source