Results 21 to 30 of about 77,446 (306)

Colchicine-Binding Site Inhibitors from Chemistry to Clinic: A Review

Pharmaceuticals, 2020
It is over 50 years since the discovery of microtubules, and they have become one of the most important drug targets for anti-cancer therapies. Microtubules are predominantly composed of the protein tubulin, which contains a number of different binding ...
Eavan C. McLoughlin, Niamh M. O’Boyle
semanticscholar   +1 more source

Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction.

New England Journal of Medicine, 2019
BACKGROUND Experimental and clinical evidence support the role of inflammation in atherosclerosis and its complications. Colchicine is an orally administered, potent antiinflammatory medication that is indicated for the treatment of gout and pericarditis.
J. Tardif, S. Kouz, D. Waters, O. Bertrand, R. Diaz, A. Maggioni, F. Pinto, R. Ibrahim, H. Gamra, G. Kiwan, C. Berry, J. López-Sendón, P. Ostadal, W. Koenig, D. Angoulvant, J. Grégoire, M. Lavoie, M. Dubé, D. Rhainds, Mylène Provencher, L. Blondeau, Andreas Orfanos, P. L’allier, M. Guertin, F. Roubille   +24 more
semanticscholar   +1 more source

Case Report: Colchicine Toxicokinetic Analysis in a Poisoned Child Requiring Extracorporeal Life Support

Frontiers in Pediatrics, 2021
Colchicine poisoning is associated with a poor prognosis, especially when leading to shock and multi-organ failure, and management is limited to supportive care, including multiple-dose activated charcoal.
Maria Pérez Marín, Sylvain Prod'hom, Suzanne Francesca de Villiers, Thomas Ferry, Vivianne Amiet, Julia Natterer, Maria-Helena Perez, Thierry Buclin, Haithem Chtioui, David Longchamp   +9 more
doaj   +1 more source

Colchicine for prevention of vascular inflammation in Non-CardioEmbolic stroke (CONVINCE) – study protocol for a randomised controlled trial

European Stroke Journal, 2021
Background Inflammation contributes to unstable atherosclerotic plaque and stroke. In randomised trials in patients with coronary disease, canukinumab (an interleukin-1B antagonist) and colchicine (a tubulin inhibitor with pleiotropic anti-inflammatory ...
P. Kelly, C. Weimar, R. Lemmens, S. Murphy, F. Purroy, A. Arsovska, N. Bornstein, A. Członkowska, U. Fischer, Ana Catarina Fonseca, J. Forbes, M. Hill, D. Jatužis, J. Kõrv, C. Kruuse, R. Mikulík, Paul J Nederkoorn, M. O’Donnell, P. Sandercock, D. Tanné, G. Tsivgoulis, C. Walsh, David J Williams, M. Zedde, C. Price   +24 more
semanticscholar   +1 more source

Anticancer effects of clinically acceptable colchicine concentrations on human gastric cancer cell lines

Kaohsiung Journal of Medical Sciences, 2016
Colchicine is a very cheap microtubule destabilizer. Because microtubules are an ideal target for anticancer drugs, the purpose of this study was to investigate whether clinically acceptable colchicine concentrations have anticancer effects on gastric ...
Zu-Yau Lin, Chao-Hung Kuo, Deng-Chyang Wu, Wan-Long Chuang   +3 more
doaj   +1 more source

Destabilising microtubule polymerization regulates chondrocyte dedifferentiation and inflammation via nuclear factor kappa b and β-catenin pathway

Bangladesh Journal of Pharmacology, 2023
The role of cell morphological changes in colchicine-inhibited tubulin polymerization of rabbit articular chondrocytes and their involvement in dedifferentiation were investigated.
Yohan Han, Young Seok Eom, Fahad Hassan Shah, Song Ja Kim   +3 more
doaj   +1 more source

Colchicine treatment can improve outcomes of coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis

Clinical and Experimental Pharmacology and Physiology, 2021
Currently, there is no widely acceptable and proven effective treatment for coronavirus disease 2019 (COVID‐19). Colchicine has been shown to offer a benefit in reducing the inflammation in several inflammatory diseases.
T. Hariyanto, D. A. Halim, C. Jodhinata, T. Yanto, A. Kurniawan   +4 more
semanticscholar   +1 more source

COLCHICINE [PDF]

The Journal of Nervous and Mental Disease, 1876
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openaire   +2 more sources

Colchicine in overdose [PDF]

British Journal of General Practice, 2017
We read with interest the letter from Lloyd warning of the danger of colchicine overdose1 and agree that this can have devastating consequences. However, the …
Christian D Mallen, Edward Roddy
openaire   +3 more sources

Discovery of new quinolines as potent colchicine binding site inhibitors: design, synthesis, docking studies, and anti-proliferative evaluation

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Discovering of new anticancer agents with potential activity against tubulin polymerisation is still a promising approach. Colchicine binding site inhibitors are the most relevant anti-tubulin polymerisation agents.
Mohamed Hagras, Moshira A. El Deeb, Heba S. A. Elzahabi, E. Elkaeed, Ahmed B. M. Mehany, I. Eissa   +5 more
semanticscholar   +1 more source