Results 31 to 40 of about 45,519 (269)

Case Report: Colchicine Toxicokinetic Analysis in a Poisoned Child Requiring Extracorporeal Life Support

Frontiers in Pediatrics, 2021
Colchicine poisoning is associated with a poor prognosis, especially when leading to shock and multi-organ failure, and management is limited to supportive care, including multiple-dose activated charcoal.
Maria Pérez Marín, Sylvain Prod'hom, Suzanne Francesca de Villiers, Thomas Ferry, Vivianne Amiet, Julia Natterer, Maria-Helena Perez, Thierry Buclin, Haithem Chtioui, David Longchamp   +9 more
doaj   +1 more source

Discovery of new quinolines as potent colchicine binding site inhibitors: design, synthesis, docking studies, and anti-proliferative evaluation

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Discovering of new anticancer agents with potential activity against tubulin polymerisation is still a promising approach. Colchicine binding site inhibitors are the most relevant anti-tubulin polymerisation agents.
Mohamed Hagras, Moshira A. El Deeb, Heba S. A. Elzahabi, E. Elkaeed, Ahmed B. M. Mehany, I. Eissa   +5 more
semanticscholar   +1 more source

In silico study of colchicine resistance molecular mechanisms caused by tubulin structural polymorphism.

PLoS ONE, 2019
Starting from 1972, colchicine is known as the most useful drug for prevention of familial Mediterranean fever attacks. However, some patients do not respond to colchicine treatment, even taken in high doses.
Harutyun Sahakyan, Narek Abelyan, Vahram Arakelov, Grigor Arakelov, Karen Nazaryan   +4 more
doaj   +1 more source

Biorhizome: A Biosynthetic Platform for Colchicine Biomanufacturing

Frontiers in Plant Science, 2017
Colchicine is one of the oldest plant-based medicines used to treat gout and one of the most important alkaloid-based antimitotic drugs with anticancer potential, which is commercially extracted from Gloriosa superba.
Ganapathy Sivakumar, Kamran Alba, Gregory C. Phillips   +2 more
doaj   +1 more source

Effects of colchicine on major adverse cardiac events in next 6-month period after acute coronary syndrome occurrence; a randomized placebo-control trial

BMC Cardiovascular Disorders, 2021
Background Cardiovascular disease in particular acute coronary syndrome (ACS) is remained one of the most cause of morbidity and mortality, annually.
Mehdi Akrami, P. Izadpanah, Mehdi Bazrafshan, Unes Hatamipour, Navid Nouraein, Hamed Bazrafshan Drissi, A. Manafi   +6 more
semanticscholar   +1 more source

Colchicine for prevention of vascular inflammation in Non-CardioEmbolic stroke (CONVINCE) – study protocol for a randomised controlled trial

European Stroke Journal, 2021
Background Inflammation contributes to unstable atherosclerotic plaque and stroke. In randomised trials in patients with coronary disease, canukinumab (an interleukin-1B antagonist) and colchicine (a tubulin inhibitor with pleiotropic anti-inflammatory ...
P. Kelly, C. Weimar, R. Lemmens, S. Murphy, F. Purroy, A. Arsovska, N. Bornstein, A. Członkowska, U. Fischer, Ana Catarina Fonseca, J. Forbes, M. Hill, D. Jatužis, J. Kõrv, C. Kruuse, R. Mikulík, Paul J Nederkoorn, M. O’Donnell, P. Sandercock, D. Tanné, G. Tsivgoulis, C. Walsh, David J Williams, M. Zedde, C. Price   +24 more
semanticscholar   +1 more source

Clinically acceptable colchicine concentrations have potential for the palliative treatment of human cholangiocarcinoma

Kaohsiung Journal of Medical Sciences, 2015
Microtubules are an ideal target for anticancer drugs because of their essential role in mitosis. Colchicine is a microtubule destabilizer. Whether the clinically acceptable colchicine concentrations had anticancer effects on human cholangiocarcinoma ...
Chun-Chieh Wu, Zu-Yau Lin, Chao-Hung Kuoc, Wan-Long Chuang   +3 more
doaj   +1 more source

Successfully Treated Severe Colchicine Intoxication in an Adolescent

Türk Yoğun Bakim Derneği Dergisi, 2022
The contain is extracted from the autumn crocus plant, colchicine that an anti-inflammatory drug. The use of colchicine impairs mobilization and activation of neutrophil and supporting treating from some rheumatological diseases especially in childhood ...
Hatice Feray Arı, Berna Kırhan, Murat Arı   +2 more
doaj   +1 more source

Reducing length of hospital stay with colchicine

Journal of Infection in Developing Countries, 2022
Introduction: Colchicine is an ancient agent with well-known anti-inflammatory effects and commonly used in treatment of hyperinflammatory conditions.
Özlem Karakaş, Abdulsamet Erden, Serdar Can Güven, Berkan Armağan, Enes Seyda Sahiner, Ali Can Kurtipek, Osman Inan, Emin Gemcioglu, İhsan Ateş, Ahmet Omma, Orhan Küçüksahin   +10 more
doaj   +1 more source

Colchicine treatment can improve outcomes of coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis

Clinical and Experimental Pharmacology and Physiology, 2021
Currently, there is no widely acceptable and proven effective treatment for coronavirus disease 2019 (COVID‐19). Colchicine has been shown to offer a benefit in reducing the inflammation in several inflammatory diseases.
T. Hariyanto, D. A. Halim, C. Jodhinata, T. Yanto, A. Kurniawan   +4 more
semanticscholar   +1 more source