Results 31 to 40 of about 86,831 (312)

On the dynamics of the microfilament system in HeLa cells [PDF]

, 1982
We measured the pools of unpolymerized and filamentous actin in homogenates of HeLa cells made in several different lysis buffers, as well as after treatment of cells with a variety of chemicals or trypsin, and after adenovirus (type 2) infection.
Blikstad, Ingrid, Carlsson, Lars
core   +3 more sources

Clinically acceptable colchicine concentrations have potential for the palliative treatment of human cholangiocarcinoma

Kaohsiung Journal of Medical Sciences, 2015
Microtubules are an ideal target for anticancer drugs because of their essential role in mitosis. Colchicine is a microtubule destabilizer. Whether the clinically acceptable colchicine concentrations had anticancer effects on human cholangiocarcinoma ...
Chun-Chieh Wu, Zu-Yau Lin, Chao-Hung Kuoc, Wan-Long Chuang   +3 more
doaj   +1 more source

Exploring the Origin of Differential Binding Affinities of Human Tubulin Isotypes αβII, αβIII and αβIV for DAMA-Colchicine Using Homology Modelling, Molecular Docking and Molecular Dynamics Simulations. [PDF]

PLoS ONE, 2016
Tubulin isotypes are found to play an important role in regulating microtubule dynamics. The isotype composition is also thought to contribute in the development of drug resistance as tubulin isotypes show differential binding affinities for various anti-
Bajarang Vasant Kumbhar, Anubhaw Borogaon, Dulal Panda, Ambarish Kunwar   +3 more
doaj   +1 more source

Neutrophil and lymphocyte responses to oral Streptococcus in Adamantiades-Behcet's disease [PDF]

, 2005
Immune reactions against microorganisms play an important pathogenic role in Adamantiades-Behçet’s disease (ABD). We had previously obtained Streptococcus sanguinis (strain BD113-20) isolated from the oral cavity of patients with ABD.
Aoki, Aridogan, Bowden, Celet, Direskeneli, Direskeneli, Doran, Emiko Isogai, Frandsen, Frassanito, Hiroshi Isogai, Hiroshi Ohtsuki, Isogai, Katsantonis, Keiji Oguma, Kenji Yokota, Lehner, Mantas, Martin, Misumi, Raziuddin, Sakane, Sugi-Ikai, Tomomi Kurauchi, Toshihiko Matsuo, Turan, Wanahita, Yokota, Yokota, Yoshihito Fujinami, Zouboulis   +30 more
core   +1 more source

Effects of colchicine use on ischemic and hemorrhagic stroke risk in diabetic patients with and without gout

Scientific Reports, 2022
This study aimed to determine the effect of colchicine use on the risk of stroke among patients with diabetes mellitus (DM). We retrospectively enrolled patients with DM between 2000 and 2013 from the Longitudinal Health Insurance Database and divided ...
Jun-Jun Yeh, I-Ling Kuo, Hei-Tung Yip, Min-Yuan Hsueh, Chung-Y. Hsu, Chia-Hung Kao   +5 more
doaj   +1 more source

Low-dose colchicine prevents sympathetic denervation after myocardial ischemia-reperfusion: a new potential protective mechanism

Future Science OA, 2021
Purpose: To evaluate the impact of colchicine on sympathetic denervation after acute myocardial infarction (AMI). Materials & methods: Ischemia/Reperfusion was induced in C57BL/6J male mice.
Fabien Huet, Jérémy Fauconnier, Marion Legall, Pierre Sicard, Catherine Lozza, Alain Lacampagne, François Roubille   +6 more
doaj   +1 more source

Biosynthesis of Colchicine [PDF]

Nature, 1960
OF several proposals1–4 concerning the biogenesis of the alkaloid colchicine (5; R 1 = R 2 = Me), only that of Wenkert4 involves the intervention of an intact tropolone ring prior to formation of ring B.
openaire   +2 more sources

Transcriptome analysis reveals plant response to colchicine treatment during on chromosome doubling

Scientific Reports, 2017
Colchicine was commonly used to artificially double chromosomes while the transcriptome changes in colchicine treated plants has rarely been characterized.
Kai Zhou, Paige Fleet, Eviatar Nevo, Xinquan Zhang, Genlou Sun   +4 more
doaj   +1 more source

Colchicine-Related Polyneuropathy and Multiple Organ Failure

Türk Nöroloji Dergisi, 2013
Colchicine arrests microtubule assembly and inhibits many cellular functions. This drug is used to treat gout and and Familial Mediterranean Fever. Its gastrointestinal side effects are frequent but more severe adverse effects such as neuropathy and ...
Ersel Dağ, Yakup Türkel, Burcu Gökçe
doaj   +1 more source

Fusion of secretory vesicles isolated from rat liver [PDF]

, 1978
Secretory vesicles isolated from rat liver were found to fuse after exposure to Ca2+. Vescle fusion is characterized by the occurrence of twinned vesicles with a continuous cleavage plane between two vesicles in freeze-fracture electron microscopy.
A. Amsterdam, A. Ichikawa, A. Lernmark, A.R. Poole, B. Hellman, B. Rose, C. Miller, C. Schudt, C. Schudt, C.M. Croge, D. Banerjee, D. Branton, D. Papahadjopoulos, D. Papahadjopoulos, D. Papahadjopoulos, D. Papahadjopoulos, D. Papahadjopoulos, E.K. Matthews, E.L. Pesanti, F. Malaisse-Lagae, G. Dahl, G. Dahl, G. Dahl, G. Poste, G. Virgilis De, G.M. Grodsky, G.R. Lawford, Gerhard Dahl, H. Schachter, J. Stadler, J.H. Ehrenreich, J.J.M. Bergeron, J.L. Mongar, J.S. Hong, L. Keay, L. Winquist, L.E. Hokin, M. Gratzl, M. Gratzl, M. Gratzl, M. Gratzl, M. Raiteri, M. Redman, M. Reporter, M.G. Farquar, Manfred Gratzl, N.A. Thorn, O. Stein, O.H. Lowry, P. Röhlich, P. Seeman, Q.F. Ahkong, R. Dipolo, R. Ekholm, R. Llinás, R. Miledi, R.C. Baker, R.D. Andrew, R.M. Case, R.P. Rubin, S.J. Burwen, T. Kanno, T. Maeda, T.Ch. Normann, W. Berger, W. Breisblatt, W. Breisblatt, W.W. Douglas, W.W. Douglas, W.W. Douglas, W.W. Douglas, W.W. Douglas, W.W. Douglas, W.W. Douglas, W.W. Douglas, Y. Marchand Le   +75 more
core   +1 more source