Results 31 to 40 of about 77,446 (306)

Discovery and engineering of colchicine alkaloid biosynthesis

Nature, 2020
Few complete pathways have been established for the biosynthesis of medicinal compounds from plants. Accordingly, many plant-derived therapeutics are isolated directly from medicinal plants or plant cell culture1.
Ryan S. Nett, Warren Lau, Elizabeth S. Sattely   +2 more
semanticscholar   +1 more source

Colchicine for the treatment of COVID-19.

Cochrane Database of Systematic Reviews, 2021
BACKGROUND The development of severe coronavirus disease 2019 (COVID-19) and poor clinical outcomes are associated with hyperinflammation and a complex dysregulation of the immune response.
A. Mikołajewska, Anna-Lena Fischer, V. Piechotta, Anika Mueller, Maria-Inti Metzendorf, M. Becker, E. Dorando, R. Pacheco, A. Martimbianco, R. Riera, N. Skoetz, M. Stegemann   +11 more
semanticscholar   +1 more source

Reducing length of hospital stay with colchicine

Journal of Infection in Developing Countries, 2022
Introduction: Colchicine is an ancient agent with well-known anti-inflammatory effects and commonly used in treatment of hyperinflammatory conditions.
Özlem Karakaş, Abdulsamet Erden, Serdar Can Güven, Berkan Armağan, Enes Seyda Sahiner, Ali Can Kurtipek, Osman Inan, Emin Gemcioglu, İhsan Ateş, Ahmet Omma, Orhan Küçüksahin   +10 more
doaj   +1 more source

Association between treatment with colchicine and improved survival in a single-centre cohort of adult hospitalised patients with COVID-19 pneumonia and acute respiratory distress syndrome

Annals of the Rheumatic Diseases, 2020
Objectives The outbreak of COVID-19 posed the issue of urgently identifying treatment strategies. Colchicine was considered for this purpose based on well-recognised anti-inflammatory effects and potential antiviral properties.
M. Scarsi, S. Piantoni, E. Colombo, P. Airó, D. Richini, M. Miclini, V. Bertasi, M. Bianchi, D. Bottone, Patrizia Civelli, M. Cotelli, E. Damiolini, G. Galbassini, D. Gatta, M. Ghirardelli, R. Magri, Paola Malamani, M. Mendeni, Stefano Molinari, A. Morotti, Luisa Salada, M. Turla, A. Vender, A. Tincani, A. Brucato, F. Franceschini, R. Furloni, L. Andreoli   +27 more
semanticscholar   +1 more source

Consensus Virtual Screening Protocol Towards the Identification of Small Molecules Interacting with the Colchicine Binding Site of the Tubulin‐microtubule System

Molecular Informatics, Volume 42, Issue 1, January 2023., 2023
Abstract Modification of the tubulin‐microtubule (Tub‐Mts) system has generated effective strategies for developing different treatments for cancer. A huge amount of clinical data about inhibitors of the tubulin‐microtubule system have supported and validated the studies on this pharmacological target.
Edgar López‐López, Carlos M. Cerda‐García‐Rojas, José L. Medina‐Franco   +2 more
wiley   +1 more source

Biorhizome: A Biosynthetic Platform for Colchicine Biomanufacturing

Frontiers in Plant Science, 2017
Colchicine is one of the oldest plant-based medicines used to treat gout and one of the most important alkaloid-based antimitotic drugs with anticancer potential, which is commercially extracted from Gloriosa superba.
Ganapathy Sivakumar, Kamran Alba, Gregory C. Phillips   +2 more
doaj   +1 more source

Effects of Acute Colchicine Administration Prior to Percutaneous Coronary Intervention

Circulation. Cardiovascular Interventions, 2020
Supplemental Digital Content is available in the text. Background: Vascular injury and inflammation during percutaneous coronary intervention (PCI) are associated with increased risk of post-PCI adverse outcomes.
Binita Shah, M. Pillinger, Hua Zhong, B. Cronstein, Yuhe Xia, J. Lorin, Nathaniel R. Smilowitz, F. Feit, Nicole Ratnapala, N. Keller, S. Katz   +10 more
semanticscholar   +1 more source

Effects of colchicine on major adverse cardiac events in next 6-month period after acute coronary syndrome occurrence; a randomized placebo-control trial

BMC Cardiovascular Disorders, 2021
Background Cardiovascular disease in particular acute coronary syndrome (ACS) is remained one of the most cause of morbidity and mortality, annually.
Mehdi Akrami, P. Izadpanah, Mehdi Bazrafshan, Unes Hatamipour, Navid Nouraein, Hamed Bazrafshan Drissi, A. Manafi   +6 more
semanticscholar   +1 more source

Anti-inflammatory therapy for COVID-19 infection: the case for colchicine

Annals of the Rheumatic Diseases, 2020
The search for effective COVID-19 management strategies continues to evolve. Current understanding of SARS-CoV-2 mechanisms suggests a central role for exaggerated activation of the innate immune system as an important contributor to COVID-19 adverse ...
A. Reyes, K. Hu, J. Teperman, T. W. Wampler Muskardin, J. Tardif, B. Shah, M. Pillinger   +6 more
semanticscholar   +1 more source

In silico study of colchicine resistance molecular mechanisms caused by tubulin structural polymorphism.

PLoS ONE, 2019
Starting from 1972, colchicine is known as the most useful drug for prevention of familial Mediterranean fever attacks. However, some patients do not respond to colchicine treatment, even taken in high doses.
Harutyun Sahakyan, Narek Abelyan, Vahram Arakelov, Grigor Arakelov, Karen Nazaryan   +4 more
doaj   +1 more source