Results 41 to 50 of about 5,105,198 (264)
Differing impact of phosphoglycerate mutase 1-deficiency on brown and white adipose tissue
iScience, 2022 Summary: Brown adipose tissue (BAT) is a metabolically active organ that contributes to the thermogenic response to cold exposure. In addition, other thermogenic cells termed beige adipocytes are generated in white adipose tissue (WAT) by cold exposure ...
Yohko Yoshida +9 more
doaj +1 more source
Cold-active enzymes in food biotechnology : An updated mini review
, 2018 Cold-active enzymes and their anticipated application in various industries including food industry attracted attention of worldwide scientific community.
M. Kuddus
semanticscholar +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Astroenzymology – the environmental limits of enzyme activity [PDF]
, 2003 Using organisms from extreme terrestrial environments as models for extraterrestrial life may lead us to underestimate the range of environments that life may inhabit.
Daniel, Roy M., Roy Daniel
core +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Isolation and characterization of EstC, a new cold-active esterase from Streptomyces coelicolor A3(2). [PDF]
PLoS ONE, 2012 The genome sequence of Streptomyces coelicolor A3(2) contains more than 50 genes coding for putative lipolytic enzymes. Many studies have shown the capacity of this actinomycete to store important reserves of intracellular triacylglycerols in nutrient ...
Guillaume Brault +4 more
doaj +1 more source
Microbial hydrolytic enzymes: In silico studies between polar and tropical regions [PDF]
, 2019 Enzyme is important as biocatalyst for industrial and biotechnological applications. Cold active enzymes have showed many advantages compare to mesophilic enzymes. Their cold active and thermolabile characteristics have shown potential benefits in many
Abdul Hamid, Azzmer Azzar +2 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
PRACTICALLY VALUABLE METABOLITES OF MARINE MICROORGANISMS [PDF]
Biotechnologia Acta, 2020 The review considered the modern literature data on the synthesis by fungi, actinobacteria, and bacteria isolated from marine ecosystems (seawater, bottom sediments, flora and fauna, mangrove biomes, glaciers), practically valuable metabolites.
T. P. Pirog
doaj +1 more source