Results 41 to 50 of about 251,552 (274)

Differing impact of phosphoglycerate mutase 1-deficiency on brown and white adipose tissue

iScience, 2022
Summary: Brown adipose tissue (BAT) is a metabolically active organ that contributes to the thermogenic response to cold exposure. In addition, other thermogenic cells termed beige adipocytes are generated in white adipose tissue (WAT) by cold exposure ...
Yohko Yoshida, Ippei Shimizu, Yung-Ting Hsiao, Masayoshi Suda, Goro Katsuumi, Masahide Seki, Yutaka Suzuki, Shujiro Okuda, Tomoyoshi Soga, Tohru Minamino   +9 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Isolation and characterization of EstC, a new cold-active esterase from Streptomyces coelicolor A3(2). [PDF]

PLoS ONE, 2012
The genome sequence of Streptomyces coelicolor A3(2) contains more than 50 genes coding for putative lipolytic enzymes. Many studies have shown the capacity of this actinomycete to store important reserves of intracellular triacylglycerols in nutrient ...
Guillaume Brault, François Shareck, Yves Hurtubise, François Lépine, Nicolas Doucet   +4 more
doaj   +1 more source

Astroenzymology – the environmental limits of enzyme activity

, 2003
Using organisms from extreme terrestrial environments as models for extraterrestrial life may lead us to underestimate the range of environments that life may inhabit.
Daniel, Roy M., Roy Daniel
core   +1 more source

Proteolytic, Lipolytic and Amylolytic Bacteria Reservoir of Turkey; Cold-Adaptive Bacteria in Detergent Industry

Journal of Pure and Applied Microbiology, 2020
Enzymes which would be active in cold conditions can be used in a wide range of fields from molecular biology to detergent industry due to their low processing capacity and high activity.
Muslu Selman, Genc Berna, Adiguzel Mahmut, Albayrak Seyda, Adiguzel Ahmet   +4 more
doaj   +1 more source

PRACTICALLY VALUABLE METABOLITES OF MARINE MICROORGANISMS [PDF]

Biotechnologia Acta, 2020
The review considered the modern literature data on the synthesis by fungi, actinobacteria, and bacteria isolated from marine ecosystems (seawater, bottom sediments, flora and fauna, mangrove biomes, glaciers), practically valuable metabolites.
T. P. Pirog
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Psychrophilic microorganisms and their cold-active enzymes

Journal of Industrial Microbiology & Biotechnology, 1996
The earth's vast and varied cold environments could be rich sources of psychrophilic microorganisms growing at 5°C or below. Unfortunately, the diversity, physiology and potential of these organisms have largely been overlooked. This article focuses on psychrophiles and their cold-active enzymes and emphasizes how future studies could give basic ...
openaire   +1 more source

Identification of Stress-Related Genes and a Comparative Analysis of the Amino Acid Compositions of Translated Coding Sequences Based on Draft Genome Sequences of Antarctic Yeasts

Frontiers in Microbiology, 2021
Microorganisms inhabiting cold environments have evolved strategies to tolerate and thrive in those extreme conditions, mainly the low temperature that slow down reaction rates. Among described molecular and metabolic adaptations to enable functioning in
Marcelo Baeza, Sergio Zúñiga, Vicente Peragallo, Salvador Barahona, Jennifer Alcaino, Víctor Cifuentes   +5 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source