Results 61 to 70 of about 4,328,067 (203)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Cold-Active Pectinases and their Commercial Applications: A Review [PDF]

, 2018
Pectinases is a group of enzymes that catalyze hydrolysis of complex pectic polysaccharides of plant tissues into simpler form, for example, galacturonic acid. They are one of the enzymes that enjoy highest market place.
Jain, K., Wani, N., Malik, S.M., Sahay, S., Ahanger, F.A., Shezad, F.   +5 more
core   +1 more source

Isolation and identification of a strain producing cold-adapted β galactosidase, and purification and characterisation of the enzyme

Czech Journal of Food Sciences, 2008
Enzymes with high specific activities at low temperatures have potential uses in the food industry. Cold-adapted microorganisms are potentially useful sources of cold-active enzyme.
Wen-Yu Liu, Ying-Wu Shi, Xin-Qin Wang, Yun Wang, Chang-Qing Wei, Kai Lou   +5 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Optimizing and purifying extracellular cold- active lipase from Talaromyces pinophilus AUMC 308 for potential use in industrial detergents [PDF]

Assiut University Journal of Multidisciplinary Scientific Research
In this study, a strain of Talaromyces pinophilus AUMC 308 was used. The 15th days of fermentation at pH 6.0, 15°C with ammonium chloride as the nitrogen source were shown to be the optimal settings for the synthesis of the enzyme.
Asmaa M.A. Omar, Abdel-Nasser A. Zohri, Ahmed Y. Abdel-Malek, Osama Abdel-Hafeez Mohamed Al-Bedak   +3 more
doaj   +1 more source

Cold-active Moulds from Jammu and Kashmir, India as Potential Source of Cold-active Enzymes [PDF]

, 2013
Cold-active moulds have been isolated from the soil of ten selected sites of Jammu and Kashmir (India) in the winter season. Most of them turned out to be psychrotolerant except BPF-5 and BPF-6 which showed defective growth above 20oC, and thus were ...
Singh, Poonam, Shezad, Fakhar, Jain, Preeti, Chouhan, Deepak, Lone, Mansoor A, Sahay, Sanjay   +5 more
core  

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Characterization of a cold-active, detergent-stable metallopeptidase purified from Bacillus sp. S1DI 10 using Response Surface Methodology.

PLoS ONE, 2019
The colder regions of Earth are inhabited by cold-adapted microorganisms designated as psychrophiles that are known to produce cold-active enzymes, such as peptidases, chaperones, lipases, cellulases, and phosphatases.
Drishtant Singh, Sharad Thakur, Seema Madhumal Thayil, Anup Kumar Kesavan   +3 more
doaj   +1 more source

Origin and diversification of steroids: Co-evolution of enzymes and nuclear receptors [PDF]

, 2010
Recent sequencing of amphioxus and sea urchin genomes has provided important data for understanding the origins of enzymes that synthesize adrenal and sex steroids and the receptors that mediate physiological response to these vertebrate steroids ...
Michael E. Baker
core  

Cold-Active Lipases and Esterases: A Review on Recombinant Overexpression and Other Essential Issues

, 2022
Cold environments characterised by diverse temperatures close to or below the water freezing point dominate about 80% of the Earth’s biosphere. One of the survival strategies adopted by microorganisms living in cold environments is their expression of ...
Adam Thean Chor Leow, Ahmad Kamarudin, Nor Hafizah, Leow, Adam Thean Chor, Adamu Idris Matinja, Ali, Mohd Shukuri Mohamad, Siti Nurbaya Oslan, Matinja, Adamu Idris, Kamarudin, Nor Hafizah Ahmad, Mohd Shukuri Mohamad Ali, Thean, Adam Chor Leow, Nor Hafizah Ahmad Kamarudin, Mohamad Ali, Mohd Shukuri, Oslan, Siti Nurbaya   +12 more
core   +1 more source