Results 51 to 60 of about 5,105,198 (264)

Identification of Stress-Related Genes and a Comparative Analysis of the Amino Acid Compositions of Translated Coding Sequences Based on Draft Genome Sequences of Antarctic Yeasts

Frontiers in Microbiology, 2021
Microorganisms inhabiting cold environments have evolved strategies to tolerate and thrive in those extreme conditions, mainly the low temperature that slow down reaction rates. Among described molecular and metabolic adaptations to enable functioning in
Marcelo Baeza, Sergio Zúñiga, Vicente Peragallo, Salvador Barahona, Jennifer Alcaino, Víctor Cifuentes   +5 more
doaj   +1 more source

The Environment shapes microbial enzymes: five cold-active and salt-resistant carboxylesterases from marine metagenomes

, 2015
Most of the Earth’s biosphere is cold and is populated by cold-adapted microorganisms. To explore the natural enzyme diversity of these environments and identify new carboxylesterases, we have screened three marine metagenome gene libraries for esterase ...
Golyshin, PN, Brown, G, Popovic, A., Chernikova, TN, Jaeger, Karl-Erich, Hajighasemi, M, Tschigvintsev, A., Somody, JC, Yakimov, MM, Tran, H., Egorova, O, Tchigvintsef, D, Kovacic, Filip, Flick, R, Yakunin, A. F., Khusnutdinova, A, Golyshina, OV, Savchenko, A   +17 more
core   +1 more source

Self-Assembly of Amyloid Fibrils That Display Active Enzymes. [PDF]

, 2014
Enzyme immobilization is an important strategy to enhance the stability and recoverability of enzymes and to facilitate the separation of enzymes from reaction products.
Smith, Andrew T, Perrett, Sarah, Knowles, Tuomas PJ, Zhang, Hong, Sawyer, Elizabeth B, Entwistle, Aiman, Jackson, Antony P, Zhou, Xiao-Ming, Mason, Thomas O, Shimanovich, Ulyana, Mason, T.O., Jackson, A.P., Shimanovich, U., Zhang, H., Zhou, X.-M., Entwistle, A., Perrett, S., Knowles, T.P.J., Sawyer, E.B., Smith, A.T.   +19 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Cold-Active Pectinases and their Commercial Applications: A Review [PDF]

, 2018
Pectinases is a group of enzymes that catalyze hydrolysis of complex pectic polysaccharides of plant tissues into simpler form, for example, galacturonic acid. They are one of the enzymes that enjoy highest market place.
Jain, K., Wani, N., Malik, S.M., Sahay, S., Ahanger, F.A., Shezad, F.   +5 more
core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

A Cold-Active Flavin-Dependent Monooxygenase from Janthinobacterium svalbardensis Unlocks Applications of Baeyer–Villiger Monooxygenases at Low Temperature

, 2023
Cold-active enzymes maintain a large part of their optimal activity at low temperatures. Therefore, they can be used to avoid side reactions and preserve heat-sensitive compounds.
Loreto P. Parra (1992022), Robert Kourist (6185600), Nakia Polidori (14572925), Lucija Sovic (14683435), Andrea M. Chánique (14683432), Philipp Galuska (14683438), Daniel Kracher (3504860), Leen Assil-Companioni (9435275), Karl Gruber (141169)   +8 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Eurythermalism of a deep-sea symbiosis system from an enzymological aspect [PDF]

, 2007
The recently proposed and experimentally validated Equilibrium Model provides the most detailed description of temperature's effect on enzyme catalytic activity to date.
Lee, Charles Kai-Wu
core  

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source