Results 91 to 100 of about 76,292 (274)

Transcriptomic analysis of colistin-susceptible and colistin-resistant isolates identifies genes associated with colistin resistance in Acinetobacter baumannii [PDF]

Clinical Microbiology and Infection, 2015
The emergence of colistin-resistant Acinetobacter baumannii is concerning, as colistin is often regarded as the last option for treating multidrug-resistant (MDR) A. baumannii infections. Using mRNA sequencing, we compared whole transcriptomes of colistin-susceptible and colistin-resistant A.
Kwan Soo Ko, Jun Yeob Lee, Young Kyoung Park   +2 more
openaire   +3 more sources

Presence of New Delhi metallo-β-lactamase gene (NDM-1) in a clinical isolate of Acinetobacter junii in Argentina [PDF]

, 2016
Here we report the presence of a clinically significant A. junii blaNDM-1 positive in a 38-year-old woman who was admitted to the emergency department with a fever and leg ulcers with signs of infection.
Almuzara, Marisa, Barberis, Claudia, Cittadini, Roxana, Del Castillo M,, Lazzaro, T., Montaña, Sabrina Daiana, Ramírez, M. S., Uong, S., Vay, Carlos Alberto   +8 more
core   +1 more source

In silico, in vitro and ex vivo characterization of cystic fibrosis transmembrane conductance regulator pathogenic variants localized in the fourth intracellular loop and their rescue by modulators

British Journal of Pharmacology, EarlyView.
Background and Purpose Cystic fibrosis (CF) is due to loss‐of‐function variants of the CF transmembrane conductance regulator (CFTR) channel. The most effective treatment for people with CF carrying the F508del mutation is the triple combination of elexacaftor–tezacaftor–ivacaftor (ETI).
Emanuela Pesce, Valeria Tomati, Valeria Capurro, Mariateresa Lena, Cristina Pastorino, Miro Astore, Serdar Kuyucak, Benoit Chevalier, Elvira Sondo, Federico Cresta, Alice Dighero, Vito Terlizzi, Cristina Fevola, Stefano Costa, Maria Cristina Lucanto, Valeria Daccò, Laura Claut, Francesca Ficili, Benedetta Fabrizzi, Renata Bocciardi, Federico Zara, Carlo Castellani, Luis J. V. Galietta, Shafagh A. Waters, Alexandre Hinzpeter, Nicoletta Pedemonte   +25 more
wiley   +1 more source

Colistin pharmacokinetics: the fog is lifting [PDF]

Clinical Microbiology and Infection, 2012
Colistin is a re-emerging old antibiotic that is used to treat multidrug-resistant infections in critically ill patients. It corresponds to a mixture of at least 30 different compounds administered as inactive derivatives. Therefore, colistin pharmacokinetics are quite difficult to investigate and complex to predict.
Nicolas Grégoire, William Couet, Sandrine Marchand, Olivier Mimoz   +3 more
openaire   +3 more sources

LABORATORY DETECTION OF COLISTIN-RESISTANT ENTEROBACTERALES IN TANDEM WITH ROUTINE ANTIBIOGRAM

Problems of Infectious and Parasitic Diseases
Since the emergence and spread of carbapenemase-producing Enterobacterales, particularly those carrying metallo-β-lactamases with 16S rRNA methyltransferases for which newly introduced antibiotics are inactive, colistin is a last resort therapy for life-
Stefana Sabtcheva
doaj   +1 more source

In vitro Activity of Pentamidine Alone and in Combination With Aminoglycosides, Tigecycline, Rifampicin, and Doripenem Against Clinical Strains of Carbapenemase-Producing and/or Colistin-Resistant Enterobacteriaceae [PDF]

, 2018
Enterobacteriaceae cause different types of community- and hospital-acquired infections. Moreover, the spread of multidrug-resistant Enterobacteriaceae is a public health problem and the World Health Organization pointed them among the pathogens in which
Cebrero Cangueiro, Tania, Cordero Matia, María Elisa, Labrador Herrera, Gema, Smani, Younes, Álvarez Marín, Rocío   +4 more
core   +1 more source

Delphi Consensus Among French Obesity Experts on Clinical Recommendations for Drug Prescription in Patients With Severe Obesity

Obesity Reviews, EarlyView.
ABSTRACT Introduction Although the physiologic alterations seen in obesity often affect the pharmacokinetics and pharmacodynamics of drugs, most clinical trials do not consider these aspects specifically for this population. To date, there is no list of potentially inappropriate medications for patients living with obesity. The aim of this study was to
Sarah Berdot, Germain Perrin, Emmanuel Disse, Armelle Arnoux, Eric Bertin, Anne‐Laure Borel, Marie‐Claude Brindisi, Arnaud De Luca, Edouard‐Jules Laforgue, Jean‐Daniel Lalau, Yann Matussiere, Emilie Montastier, Agnès Sallé, Bérénice Segrestin, Valentine Suteau, French Hospital Expert Panel, Sebastien Czernichow, Brigitte Sabatier   +17 more
wiley   +1 more source

Characterization of newly isolated lytic bacteriophages active against Acinetobacter baumannii [PDF]

, 2014
Based on genotyping and host range, two newly isolated lytic bacteriophages, myovirus vB_AbaM_Acibel004 and podovirus vB_AbaP_Acibel007, active against Acinetobacter baumannii clinical strains, were selected from a new phage library for further ...
De Vos, Daniel, Kropinski, Andrew M, Lavigne, Rob, Mast, Jan, Merabishvili, Maia, Noben, Jean-Paul, Pirnay, Jean-Paul, Vandenheuvel, Dieter, Vaneechoutte, Mario, Verbeken, Gilbert   +9 more
core   +4 more sources

Environmental Dissemination of Multidrug‐Resistant Gram‐Negative Pathogens in Djibouti's Wastewaters

Public Health Challenges, Volume 4, Issue 4, December 2025.
ABSTRACT Background The occurrence of multidrug‐resistant (MDR) Enterobacteriaceae‐producing extended‐spectrum β‐lactamases (ESBLs) and/or carbapenemases is increasingly reported in clinical and environmental settings. Here, we aimed to investigate the resistance profile of gram‐negative bacterial isolates from urban and environmental wastewater in ...
Ayan Ali Ragueh, Ibrahim S. Abdallah, Rachid M. Mouhoumed, Mohamed H. Aboubaker, Seydina M. Diene   +4 more
wiley   +1 more source

Pharmacokinetics of Colistin in Cerebrospinal Fluid after Intraventricular Administration of Colistin Methanesulfonate [PDF]

Antimicrobial Agents and Chemotherapy, 2012
ABSTRACT Intraventricular colistin, administered as colistin methanesulfonate (CMS), is the last resource for the treatment of central nervous system infections caused by panresistant Gram-negative bacteria. The doses and daily regimens vary considerably and are empirically chosen; the cerebrospinal fluid (CSF) pharmacokinetics ...
Imberti, Roberto, Cusato, Maria, Accetta, Giovanni, Marinò, Valeria, Procaccio, Francesco, Del Gaudio, Alfredo, Regazzi, Mario, IOTTI, GIORGIO ANTONIO   +7 more
openaire   +4 more sources