Results 101 to 110 of about 71,995 (190)

Clinical and in vitro efficacy of colistin plus vancomycin and rifampin against colistin-resistant Acinetobacter baumannii causing ventilator-associated pneumonia [PDF]

, 2017
We present the case of a patient with ventilator-associated pneumonia (VAP) caused by a pan-resistant Acinetobacter baumannii successfully treated with the combination colistin plus vancomycin plus rifampin, whose in vitro activity was investigated by ...
Cipolla, Alessia, Falcone, Marco, Mastroianni, Claudio Maria, Oliva, Alessandra, Venditti, Mario, Vullo, Vincenzo   +5 more
core   +1 more source

Phylogeny, Resistome, and Virulome of Escherichia coli Causing Biliary Tract Infections [PDF]

, 2019
Escherichia coli is the most frequent Gram-negative bacilli involved in intra-abdominal infections. However, despite high mortality rates associated with biliary tract infections due to E. coli, there is no study focusing on this pathogen. In this study,
Aznar Martín, Javier, Bonnin, Rémy A., Lepe, José A., Naas, Thierry, Ortiz de la Rosa, José Manuel, Pachón, Jerónimo, Rodríguez-Villodres, Ángel, Smani, Younes, Álvarez-Marín, Rocío   +8 more
core   +2 more sources

Effect of colistin-tigecycline combination on colistin-resistant and carbapenem-resistant Klebsiella pneumoniae and Acinetobacter baumannii

Microbiology Spectrum
There is a critical need for treatment strategies to combat carbapenem-resistant Gram-negative pathogens. This study investigates the efficacy of combining low concentrations of colistin with tigecycline against colistin- and carbapenem-resistant ...
Suyeon Park, Yanhong Jin, Kwan Soo Ko
doaj   +1 more source

Application of luciferase assay for ATP to antimicrobial drug susceptibility [PDF]

, 1977
The susceptibility of bacteria, particularly those derived from body fluids, to antimicrobial agents is determined in terms of an ATP index measured by culturing a bacterium in a growth medium.
Barza, M. J., Chappelle, E. W., Picciolo, G. L., Tuttle, S. A., Vellend, H., Weinstein, L.   +5 more
core   +1 more source

Nitroxoline as an antimicrobial synergist reverses colistin resistance in multidrug-resistant Escherichia coli

iScience
Summary: Colistin is a crucial drug for treating multidrug-resistant (MDR) Escherichia coli infections. The emergence and bacterial transmission of the colistin-resistant gene mcr-1 have substantially diminished its therapeutic efficacy.
Hao Wang, Jie He, Hao Li, Chengming Li, Muhammad Inam, Jianfeng Wang, Huifeng Dong, Dingkuo Liu, Fang Liu, Jingrui Chen, Yu Jia, Yunhang Gao, Lingcong Kong, Hongxia Ma   +13 more
doaj   +1 more source

Alteration in the Morphological and Transcriptomic Profiles of Acinetobacter baumannii after Exposure to Colistin

Microorganisms
Acinetobacter baumannii is often highly resistant to multiple antimicrobials, posing a risk of treatment failure, and colistin is a “last resort” for treatment of the bacterial infection. However, colistin resistance is easily developed when the bacteria
Eun-Jeong Yoon, Jun Won Mo, Jee-woong Kim, Min Chul Jeong, Jung Sik Yoo   +4 more
doaj   +1 more source

Inhalation with intravenous loading dose of colistin in critically ill patients with pneumonia caused by carbapenem-resistant gram-negative bacteria

Therapeutic Advances in Respiratory Disease, 2019
Background: Despite the increasing use of colistin in clinical practice, the optimal dosing, and administration route have not been established. This study aimed to evaluate the clinical outcome and safety of intravenous (IV) colistin with a loading dose
Junsu Choe, You Min Sohn, Suk Hyeon Jeong, Hyo Jung Park, Soo Jin Na, Kyungmin Huh, Gee Young Suh, Kyeongman Jeon   +7 more
doaj   +1 more source

Comparative effectiveness and mortality of colistin monotherapy versus colistin-fosfomycin combination therapy for the treatment of carbapenem-resistant Enterobacteriaceae (CRE) infections: A propensity score analysis

Journal of Infection and Public Health
Background: Carbapenem-resistant Enterobacteriaceae (CRE) infections pose a significant threat to global health due to limited treatment options and high mortality rates.
Wasan Katip, Ajaree Rayanakorn, Peninnah Oberdorfer, Puntapong Taruangsri, Teerapong Nampuan, Siriporn Okonogi   +5 more
doaj   +1 more source

Double-carbapenem regimen, alone or in combination with colistin, in the treatment of infections caused by carbapenem-resistant Klebsiella pneumoniae (CR-Kp) [PDF]

, 2017
Aloj, F., Castaldi, D., D'Abramo, A., De Angelis, M., Gizzi, F., Mascellino, M. T., Mastroianni, C. M., Oliva, Alessandra, Scorzolini, L., Storto, M., Vullo, V.   +10 more
core   +1 more source

β,β-Dimethylacrylalkannin Restores Colistin Efficacy Against mcr- and TCS-Mediated Resistant Gram-Negative Bacteria via Membrane Disturbance

Antibiotics
Background: The reintroduction of colistin has led to the rapid emergence of colistin-resistant strains, significantly diminishing its therapeutic efficacy. This presents a need for effective adjuvants to restore colistin efficacy.
Yongqing Liu, Huangwei Song, Muchen Zhang, Junyao Jiang, Yan Zhang, Jian Xu, Xi Xia, Shangshang Qin, Jianzhong Shen, Yang Wang, Dejun Liu   +10 more
doaj   +1 more source