Results 91 to 100 of about 15,930 (153)

Fosmidomycin for the Treatment of Canine Otitis Externa: A Randomised, Double‐Blinded, Controlled ‘Split Body’ Clinical Trial

Veterinary Dermatology, Volume 37, Issue 3, Page 427-436, June 2026.
ABSTRACT Background Targeted antimicrobial therapy for canine otitis externa (OE) represents an opportunity for antimicrobial stewardship. Fosmidomycin selectively inhibits the non‐mevalonate pathway for isoprenoid biosynthesis utilised by canine‐adapted, and not human‐adapted, staphylococci.
Lindsey E. Citron, Darko Stefanovski, Youwen You, Rachel Proctor, Donna Watson, Julie Randall, Christine L. Cain   +6 more
wiley   +1 more source

Nonclonal Emergence of Colistin Resistance Associated with Mutations in the BasRS Two-Component System in Escherichia coli Bloodstream Isolates

mSphere, 2020
Infections by multidrug-resistant Gram-negative bacteria are increasingly common, prompting the renewed interest in the use of colistin. Colistin specifically targets Gram-negative bacteria by interacting with the anionic lipid A moieties of ...
Axel B. Janssen, Toby L. Bartholomew, Natalia P. Marciszewska, Marc J. M. Bonten, Rob J. L. Willems, Jose A. Bengoechea, Willem van Schaik   +6 more
doaj   +1 more source

Retrospective Evaluation of Colistin Associated Nephrotoxicity at Oncology Hospital Intensive Care Unit

, 2014
Objective: The aim of our study, is to determine the nephrotoxicity rates and risk factors for the development of nephrotoxicity by retrospective evaluation of patients who were given colistin therapy oncology hospital intensive care unit.
Saadet Menteş, Süheyla Ünver, Menşure Kaya, Rukiye Neslihan Kuru, Mustafa Ertek, Yeliz İrem Tunçel, Sabahat Çeken   +6 more
core   +1 more source

Pyrazolyl–Pyridine Ruthenium Complexes: A New Metallic Line of Defense Against Acinetobacter baumannii

ChemBioChem, Volume 27, Issue 9, 14 May 2026.
Ruthenium(II) (Ru(II)) pyrazolyl–pyridine half‐sandwich complexes (C1–C6) were synthesized and structurally characterized as prospective metalloantibiotics. Screening through the Community for Open Antimicrobial Drug Discovery (CO‐ADD) revealed selective activity against Acinetobacter baumannii, with favorable cytotoxicity profiles. Biophysical studies
M. Cassiem Joseph, Sheldon Sookai, Monika Nowakowska, Rotondwa Mphephu, Angela M. Kavanagh, Johannes Zuegg, Mark A. T. Blaskovich, Andrew J. Swarts   +7 more
wiley   +1 more source

Outer membrane permeability of mcr-positive bacteria reveals potent synergy of colistin and macromolecular antibiotics against colistin-resistant Acinetobacter baumannii

Frontiers in Microbiology
Colistin (CT) is the last-resort of antibiotic against multidrug-resistance (MDR) Acinetobacter baumannii (A. baumannii) infection. However, colistin resistance is increasingly reported in A.
Meisong Li, Furong Ma, Hui Zhao, Dianrong Zhou, Dianrong Zhou, Dianrong Zhou, Lujie Liang, Lujie Liang, Lujie Liang, Runling Lv, Jiachen Li, Jiachen Li, Jiachen Li, Yaxuan Wang, Yaxuan Wang, Yaxuan Wang, Lin Xu, Lin Xu, Lin Xu, Chenfei Liu, Guo-Bao Tian, Guo-Bao Tian, Guo-Bao Tian, Siyuan Feng, Siyuan Feng, Siyuan Feng, Yong Xia   +26 more
doaj   +1 more source

Colistin Use in Patients with Extreme Renal Function: From Dialysis to Augmented Clearance

Medicina, 2019
Background and objectives: Colistin is used for the treatment of multidrug-resistant (MDR) Gram-negative bacteria infection in critically ill patients. It is recommended to adjust the dose in cases of renal impairment but not in cases of augmented renal ...
Aleksandra Aitullina, Angelika Krūmiņa, Šimons Svirskis, Santa Purviņa   +3 more
doaj   +1 more source

Colistin Resistance Development Following Colistin-Meropenem Combination Therapy vs. Colistin Monotherapy in Patients with Infections Caused by Carbapenem-Resistant Organisms

, 2020
We evaluated whether carbapenem-colistin combination therapy given to patients with infections due to carbapenem-resistant Gram-negative organisms reduces the emergence of colistin resistance compared to colistin ...
Yahav, Dafna, GIURAZZA, ROBERTO, Mouton, Johan, Dickstein, Y, Bernardo, Mariano, Benattar, YD, Antoniadou, Anastasia, Antoniadou, A, Altunin, S, Rakovitsky, Nadya, Skiada, A, Altunin, Sergey, Carmeli, Y, Schwartz, David, Deliolanis, I, Rognås, Viktor, Daitch, V, Leibovici, L, Daitch, Vered, Mouton, Johan W, Paul, Mical, Rognas, V, Leibovici, Leonard, Durante-Mangoni, E, Dishon Benattar, Yael, Daikos, GL, Carmeli, Yehuda, Skiada, Anna, Paul, M, Lellouche, Jonathan, Rakovitsky, N, Lellouche, J, Nutman, Amir, Yahav, D, Dickstein, Yaakov, Deliolanis, Ioannis, Daikos, George L, Iossa, Domenico, Durante-Mangoni, Emanuele, Friberg, Lena E, Bernardo, M, Iossa, D, Friberg, LE, Schwartz, D, Nutman, A   +44 more
core   +1 more source

Molecular mechanisms related to colistin resistance in Enterobacteriaceae

, 2019
Zahra Aghapour,1,2 Pourya Gholizadeh,3 Khudaverdi Ganbarov,4 Abed Zahedi Bialvaei,5 Suhad Saad Mahmood,6 Asghar Tanomand,7 Mehdi Yousefi,8 Mohammad Asgharzadeh,9 Bahman Yousefi,9 Hossein Samadi Kafil11Drug Applied Research Center, Tabriz University of ...
Ganbarov K, Aghapour Z, Yousefi M, Yousefi B, Kafil HS, Asgharzadeh M, Gholizadeh P, Bialvaei AZ, Mahmood SS, Tanomand A   +9 more
core  

Effect of colistin-tigecycline combination on colistin-resistant and carbapenem-resistant Klebsiella pneumoniae and Acinetobacter baumannii

Microbiology Spectrum
There is a critical need for treatment strategies to combat carbapenem-resistant Gram-negative pathogens. This study investigates the efficacy of combining low concentrations of colistin with tigecycline against colistin- and carbapenem-resistant ...
Suyeon Park, Yanhong Jin, Kwan Soo Ko
doaj   +1 more source

In vitro activity of colistin mono- and combination therapy against colistin-resistant Acinetobacter baumannii, mechanism of resistance, and clinical outcomes of patients infected with colistin-resistant A. baumannii at a Thai university hospital

, 2017
Yongyut Lertsrisatit,1 Wichai Santimaleeworagun,2,3 Sudaluck Thunyaharn,4 Jantima Traipattanakul5 1College of Pharmacotherapy Thailand, Nonthaburi, Thailand; 2Department of Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakorn Pathom, Thailand ...
Lertsrisatit Y, Thunyaharn S, Traipattanakul J, Santimaleeworagun W   +3 more
core