Results 71 to 80 of about 20,481 (152)

Colistin resistance development following colistin-meropenem combination therapy versus colistin monotherapy in patients with infections caused by carbapenem-resistant organisms

, 2020
Background. We evaluated whether carbapenem-colistin combination therapy reduces the emergence of colistin resistance, compared to colistin monotherapy, when given to patients with infections due to carbapenem-resistant Gram-negative organisms.
Bernardo, M., Altunin, S., Bertolino, L., Koppel, F., Pafundi, P.C., Elbaz, M., Giurazza, R., Schwartz, D., Nutman, A., Giuffre, G., Mouton, J., Friberg, L., Antoniadou, A., Paul, M., Skiada, A., Benattar, Y.D., Daitch, V., Neuberger, A., Babich, T., Murino, P., Zampino, R., Andria, N., Raines, M., Kotsaki, A., Deliolanis, I., Atamna, H., Carmeli, Y., Cuccurullo, S., Dickstein, Y., Corcione, A., Durante-Mangoni, E., Kristoffersson, A., Bitterman, R., Karban, A., Daikos, G.L., Rognås, V., Adler, A., Andini, R., Iossa, D., Eliakim-Raz, N., Levi, I., Zak-Doron, Y., Rakovitsky, N., Friberg, L.E., Petersiel, N., Cavezza, G., Yahav, D., Galdo, M., Pavleas, I., Lellouche, J., the AIDA Study Group, Stern, A., Theuretzbacher, U., Mouton, J.W., Zusman, O., Leibovici, L., Zayyad, H., Cristinziano, A.   +57 more
core   +1 more source

Nonclonal Emergence of Colistin Resistance Associated with Mutations in the BasRS Two-Component System in Escherichia coli Bloodstream Isolates

mSphere, 2020
Infections by multidrug-resistant Gram-negative bacteria are increasingly common, prompting the renewed interest in the use of colistin. Colistin specifically targets Gram-negative bacteria by interacting with the anionic lipid A moieties of ...
Axel B. Janssen, Toby L. Bartholomew, Natalia P. Marciszewska, Marc J. M. Bonten, Rob J. L. Willems, Jose A. Bengoechea, Willem van Schaik   +6 more
doaj   +1 more source

Dissemination of Class 1, 2, and 3 Integrons Among Multidrug‐Resistant Isolates of Pseudomonas aeruginosa

MicrobiologyOpen, Volume 15, Issue 6, December 2026.
Clinical Pseudomonas aeruginosa isolates showed widespread Class 1 and 2 integrons carrying diverse resistance‐associated gene cassettes, including aadB, blaOXA10‐aac(6′)‐II, and aadB‐blaOXA10‐aac(6′)‐Ib, which were strongly associated with antibiotic resistance phenotypes, highlighting the need for enhanced surveillance and targeted infection‐control ...
Mahdi Hosseini Bafghi, Abbas Baghaie, Razieh Nazari   +2 more
wiley   +1 more source

Synergistic Activity of Colistin in Combination with Clofoctol against Colistin Resistant Gram-Negative Pathogens

, 2023
Colistin is used as a last-resort antibiotic against extensively drug-resistant Gram-negative pathogens. However, colistin resistance is on the rise.Colistin is a bactericidal antibiotic identified decades ago which is active against a number of Gram ...
Fortuna, Alessandra, Rampioni, Giordano, Collalto, Diletta, Visca, Paolo, Leoni, Livia, Imperi, Francesco, Diletta Collalto, Livia Leoni, Giordano Rampioni, Francesco Imperi, Paolo Visca, Alessandra Fortuna   +11 more
core   +1 more source

LABORATORY DETECTION OF COLISTIN-RESISTANT ENTEROBACTERALES IN TANDEM WITH ROUTINE ANTIBIOGRAM

Problems of Infectious and Parasitic Diseases
Since the emergence and spread of carbapenemase-producing Enterobacterales, particularly those carrying metallo-β-lactamases with 16S rRNA methyltransferases for which newly introduced antibiotics are inactive, colistin is a last resort therapy for life-
Stefana Sabtcheva
doaj   +1 more source

Colistin Resistance and Management of Drug Resistant Infections

Canadian Journal of Infectious Diseases and Medical Microbiology, 2022
Colistin resistance is a globalized sensible issue because it has been considered a drug of the last-line resort to treat drug-resistant bacterial infections.
Juhi Sharma, Divakar Sharma, Amit Singh, Kumari Sunita   +3 more
doaj   +1 more source

In‐Vitro Activity of Ceftazidime‐Avibactam and Comparator Agents Against Carbapenem‐Resistant Gram‐Negative Isolates at a Tertiary Care Hospital in Lahore, Pakistan: A Cross‐Sectional Study

MicrobiologyOpen, Volume 15, Issue 6, December 2026.
Of 210 consecutive non‐duplicate carbapenem‐resistant Gram‐negative isolates collected at a tertiary care hospital in Lahore, Pakistan (December 2024–May 2025), 200 had a ceftazidime‐avibactam (CAZ–AVI) result; 70.5% were susceptible (141/200; 95% CI 63.7–76.7). Susceptibility varied by sample source (p = 0.008), being highest in blood cultures (81.2%),
Faryal Yunus, Obaid Ur Rehman, Muhammad Murtaza, Safa Mazhar, Abedin Samadi, Ahmed Asad Raza   +5 more
wiley   +1 more source

Integrated Genotypic and Phenotypic Determinants Underpin the Environmental Persistence of Escherichia coli in Treated Sewage in Japan

Environmental Microbiology Reports, Volume 18, Issue 6, December 2026.
This study integrated genotypic and phenotypic analyses to investigate the persistence of Escherichia coli in treated sewage in Japan. Virulence‐positive isolates were dominated by phylogroups D and B1, with astA and blaTEM as the predominant virulence and resistance determinants. Among accessory siderophore genes, fecA and chuA were the most prevalent.
Ida Munfarida, Jant Cres Caigoy, Christian Xedzro, Toshi Shimamoto, Tadashi Shimamoto   +4 more
wiley   +1 more source

Controllable Cascade Aggregation Ion Programmed Nanomachines and Simple Isolation Enable Tumor‐Derived Small Extracellular Vesicles Detection for Enhanced Breast Cancer Assessment

Advanced Science, Volume 13, Issue 61, 3 November 2026.
This study developed a convenient, enzyme‐free detection platform based on controllable aggregation ion nanomachines. Its favorable anti‐interference capacity and high sensitivity meet the detection requirements for clinical samples processed via a simple filtration method within 10 min.
Zhihao Zhang, Zijing Liu, Xiangyue Meng, Pengjun Jiang, Jie Qu, Yu Jiang, Binxu Qiu, Jie Chen, Piaopiao Chen   +8 more
wiley   +1 more source

Bacterial Agents and Their Multidrug‐Resistance Profile Among Patients Suspected of Bacterial Infections in Hakim Gizaw Hospital, Debre Berhan, Ethiopia: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 11, November 2026.
ABSTRACT Background and Aims Antimicrobial resistance is a global threat. Bacteria showed higher resistance in Ethiopia, and up‐to‐date data on it is urgently required for effective interventions. This study aimed to determine occurrence of multi‐drug‐resistant (MDR) bacterial isolates among patients presented to Hakim Gizaw Hospital (HGH).
Tizazu Zenebe Zelelie, Ermias Endewunetu, Yosef Temesgen, Demissew Shenkute Gebreyes, Zenawork Sahile, Biniam Mekonnen, Getachew Bizuneh, Asrat Berihun, Berhanu Yitayew   +8 more
wiley   +1 more source