Results 71 to 80 of about 55,191 (217)

Nonclonal Emergence of Colistin Resistance Associated with Mutations in the BasRS Two-Component System in Escherichia coli Bloodstream Isolates

mSphere, 2020
Infections by multidrug-resistant Gram-negative bacteria are increasingly common, prompting the renewed interest in the use of colistin. Colistin specifically targets Gram-negative bacteria by interacting with the anionic lipid A moieties of ...
Axel B. Janssen, Toby L. Bartholomew, Natalia P. Marciszewska, Marc J. M. Bonten, Rob J. L. Willems, Jose A. Bengoechea, Willem van Schaik   +6 more
doaj   +1 more source

Colistin Resistance and Management of Drug Resistant Infections

Canadian Journal of Infectious Diseases and Medical Microbiology, 2022
Colistin resistance is a globalized sensible issue because it has been considered a drug of the last-line resort to treat drug-resistant bacterial infections.
Juhi Sharma, Divakar Sharma, Amit Singh, Kumari Sunita   +3 more
doaj   +1 more source

The sRNA vvrr1 Modulates the VarS/VarA‐Csr System via LeuO to Regulate Biofilm Formation and Virulence in Vibrio alginolyticus

Animal Research and One Health, EarlyView.
vvrr1, a small RNA, post‐transcriptionally represses the transcriptional regulator LeuO, which directly inhibits the VarS/VarA two‐component system. This triggers a Csr cascade that relieves LuxO repression, ultimately modulating exopolysaccharide production to control biofilm formation and virulence in Vibrio alginolyticus.
Theerakamol Pengsakul, Lei Wen, Lingmin Zhao, Bei Huang, Jiang Zheng, Binfu Xu, Lixing Huang   +6 more
wiley   +1 more source

From pathogen to “living drug factory” innovative strategies and clinical translation of bacteria as programmable intelligent vectors for cancer therapy

BMEMat, EarlyView.
Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen, Weichen Zhang, Gaoli Niu, Li Wang, Ruiyan Li, Yueyue Fan, Feixue Lu, Lingling Xu, Xiaoyuan Ji, Yong Kang   +9 more
wiley   +1 more source

Genomic Insights Into Spatiotemporal Dynamics of Acquired Azithromycin Resistance Genes in Salmonella Strains Worldwide

Food Safety and Health, EarlyView.
ABSTRACT Azithromycin has been used for clinical invasive infections caused by fluoroquinolone‐ and third‐generation cephalosporin‐resistant Salmonella, and mass drug administration with azithromycin has been used to reduce under‐5 mortality in children in some countries.
Yuhang Pei, Mengqi Qu, Ziru Yang, Xuebin Xu, Yanan Wang   +4 more
wiley   +1 more source

Polymersome‐Enabled Multimodal Delivery of Tobramycin and Doripenem for Targeted Eradication of Pseudomonas aeruginosa Biofilms in Chronic Rhinosinusitis

Small, EarlyView.
Schematic representation of diffusion‐based versus pH‐triggered drug release within a bacterial biofilm. In diffusion‐based systems, drug cargo is gradually released independent of local pH, resulting in rapid burst release and reduced sustained concentrations.
Amalie Kjær Andresen, Matteo Tollemeto, Alexander B. Cook, Claus Sternberg, Yudong Li, Claus Moser, Lars Jelsbak, Jan C. M. Van Hest, Anja Boisen, Line Hagner Nielsen   +9 more
wiley   +1 more source

Ursolic acid inhibits colistin efflux and curtails colistin resistant Enterobacteriaceae [PDF]

, 2019
Colistin resistance in Enterobacteriaceae especially Klebsiella pneumoniae and Escherichia coli is driving the evolution of pan drug resistant strains.
Subramaniam, Shankar, Sivasubamanian, Aravind, Shankar Subramaniam, Harihar M. Mohan, Subramaniapillai Selva Ganesan, Mohan, Harihar M, Aravind Sivasubamanian, Sundaramoorthy, Niranjana S, Niranjana Sri Sundaramoorthy, Thiagarajan Raman, Saisubramanian Nagarajan, Nagarajan, Saisubramanian, Raman, Thiagarajan, Selva Ganesan, Subramaniapillai   +13 more
core   +1 more source

Printing to Fight Antimicrobial Resistance Through Nano/Microstructured Platforms

The Chemical Record, EarlyView.
Additive manufacturing enables the rational design of structured antimicrobial platforms across multiple length scales, from nanofibrous scaffolds and droplet microreactors to 3D and 4D printed constructs. By engineering confinement, interfacial chemistry, and stimuli‐responsive release, these systems exert localized action through complementary ...
Giorgia Puleo, Silvia Orecchio, Dario Savoca, Claudia Pellerito, Vittorio Ferrara, Vincenzo Piscopo, Sebastiano Alberto Fortuna, Alessandra Giardina, Bruno Pignataro, Paola Costanzo, Floriana Campanile, Giuseppe Arrabito   +11 more
wiley   +1 more source

Toxicidade do antibiótico sulfato de colistina empregado na suinocultura sobre processos microbiológicos relacionados ao tratamento de efluentes [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Química, Florianópolis, 2012.O modelo atualmente empregado de produção intensiva de suínos implica na utilização de grande quantidade ...
Bressan, Cléo Rodrigo
core  

Impact of colistin and colistin-loaded on alginate nanoparticles on pigs infected with a colistin-resistant enterotoxigenic Escherichia coli strain

, 2022
International audienceColistin is frequently used for the control of post-weaning diarrhoea in pigs. Colistin resistance caused by plasmidic genes is a public health issue.
Drider, Djamel, Belguesmia, Yanath, Hazime, Noura, Le Devendec, Laetitia, Paboeuf, Frédéric, Boukherroub, Rabah, Mourand, Gwenaelle, Kempf, Isabelle   +7 more
core   +1 more source