Results 51 to 60 of about 55,191 (217)

Novel colistin-EDTA combination for successful eradication of colistin-resistant Klebsiella pneumoniae catheter-related biofilm infections

Scientific Reports, 2021
Development of an effective therapy to overcome colistin resistance in Klebsiella pneumoniae, a common pathogen causing catheter-related biofilm infections in vascular catheters, has become a serious therapeutic challenge that must be addressed urgently.
Aye Mya Sithu Shein, Dhammika Leshan Wannigama, Paul G. Higgins, Cameron Hurst, Shuichi Abe, Parichart Hongsing, Naphat Chantaravisoot, Thammakorn Saethang, Sirirat Luk-in, Tingting Liao, Sumanee Nilgate, Ubolrat Rirerm, Naris Kueakulpattana, Matchima Laowansiri, Sukrit Srisakul, Netchanok Muhummudaree, Teerasit Techawiwattanaboon, Lin Gan, Chenchen Xu, Rosalyn Kupwiwat, Phatthranit Phattharapornjaroen, Rojrit Rojanathanes, Asada Leelahavanichkul, Tanittha Chatsuwan   +23 more
doaj   +1 more source

Synergistic activity of colistin with azidothymidine against colistin-resistant Klebsiella pneumoniae clinical isolates collected from inpatients in Greek hospitals. [PDF]

, 2019
BACKGROUND: New antibiotics are urgently needed for the treatment of multidrug resistant infections. However, the production of novel antibiotics is diminishing.
Tryfinopoulou, K, Hu, Y, Colistin - Azidothymidine Hellenic Study Group, Voulgaris, GL, Kyriakidou, M, Vatopoulos, A, Falagas, ME, Giakkoupi, P, Coates, A   +8 more
core   +1 more source

Colistin-stimulated ROS production is significantly impaired by the presence of colistin resistance-conferring proteins (EptA/MCR-1/ICR-Mo).

, 2018
A & B Accumulation of hydrogen peroxide is boosted by colistin stress in E. coli. C & D The presence of plasmid-borne EptA inhibits colistin-induced production of hydrogen peroxide in E. coli.
Swaminath Srinivas (450675), Jingxia Lin (3365054), Youjun Feng (16133), Vishnu Goutham Kota (5216144), Wenhui Wei (176525), Zichen Tang (3602876), Shihua Wang (219946), Saif Ullah (2360377)   +7 more
core   +1 more source

Serotype Is Associated With High Rate of Colistin Resistance Among Clinical Isolates of Salmonella

Frontiers in Microbiology, 2020
To investigate the prevalence, probable mechanisms and serotype correlation of colistin resistance in clinical isolates of Salmonella from patients in China, Salmonella isolates were collected from fecal and blood samples of patients. In this study, 42.8%
Qixia Luo, Yuan Wang, Hao Fu, Xiao Yu, Beiwen Zheng, Yunbo Chen, Björn Berglund, Björn Berglund, Yonghong Xiao   +8 more
doaj   +1 more source

Dual‐Functional Silent‐Region SERS Nanoplatform for Real‐Time Bacterial Tracking and Wound Healing Therapy

Advanced Science, EarlyView.
ABSTRACT Bacterial wound infections, particularly those caused by Escherichia coli and Pseudomonas aeruginosa, are difficult to treat due to biofilm formation, multidrug resistance, and chronic inflammation. Here, we report a multifunctional nanoplatform based on a surface‐enhanced Raman scattering (SERS) probe that enables simultaneous photodynamic ...
Hanbin Deng, Rui Wang, Dianqi Zhang, Wei Zhang, Jaebum Choo, Fabiao Yu, Shaowen Cheng   +6 more
wiley   +1 more source

Development and validation of a high-performance liquid chromatography-fluorescence detection method for the accurate quantification of colistin in human plasma

, 2017
Recently, colistin has become one of the most important drugs for treating infections caused by multidrug-resistant Gram-negative bacteria. Therapeutic drug monitoring is recommended to ensure the safety and efficacy of colistin and to improve clinical ...
郭錦樺;孫幸筠;林淑文, Chepyala, Divyabharathi;Tsai, I-Lin;Sun, Hsin-Yun;Lin, Shu-Wen;Kuo, Ching-Hua   +1 more
core   +1 more source

Re-emerging of colistin for treatment of nosocomial pneumonia due to gram negative multi-drug resistant pathogens in critically ill patients

Egyptian Journal of Chest Disease and Tuberculosis, 2013
Background: Gram-negative (G-ve) bacilli, particularly Pseudomonas aeruginosa and Acinetobacter baumannii, are important opportunistic multidrug-resistant (MDR) pathogens in hospitalized patients, contributing to their morbidity and mortality.
Mohamed Amin, Alaa Rashad, Assem Fouad, Amal Abdel Azeem   +3 more
doaj   +1 more source

The role of pmrCAB genes in colistin-resistant Acinetobacter baumannii

Scientific Reports, 2022
The progressively increasing antimicrobial-resistant Acinetobacter baumannii infections have enforced the use of colistin as the last option for therapy, resulting in the colistin resistance evolution. This work aimed to study the pmrCAB expression in A.
Shaimaa Mohamed Seleim, Marwa Salah Mostafa, Nadia Hafez Ouda, Rania Yahia Shash   +3 more
doaj   +1 more source

Convergence of Plasmid‐Mediated tmexCD‐toprJ With Critical Resistance Genes Fuels Spread of Multidrug Resistant Bacteria

Advanced Science, EarlyView.
Global dissemination of tmexCD‐toprJ across bacterial hosts and ecological niches is accompanied by its convergence with blaKPC, blaNDM, and mcr on mobile plasmids. Recombination and acquisition of resistance modules generate distinct multidrug resistant plasmid architectures, facilitating the emergence and spread of high‐risk bacterial populations ...
Kaiwen Song, Meng Wang, Xingyu Wu, Meng Cai, Bowen Li, Qi Wang, Xiaodong Guan, Qi Ding, Ruobing Wang, Hui Wang   +9 more
wiley   +1 more source

Reversible Nephrotoxicity of Colistin: A Case Report

, 2019
Both nosocomial and community acquired gram-negative bacterial infections cause serious morbidity and mortality. However, old antibiotics, which have toxic side effects, should be re-used because of the lack of newly developed antibiotics.
Güle Çınar, İrem Akdemir Kalkan, Kemal Osman Memikoğlu   +2 more
core   +1 more source